Supervisor: BARKÓ, Szilvia
Co-supervisor: Dr. BÓDIS, Emőke
If you think- as you have learnt - that bacteria are simpler than eukaryotic organisms-you are wrong.
In the last decades it turned out that these tiny entities are much more sophisticated as it was imagined ever. They possess the homologues of the most important eukaryotic proteins and these homologues can present link between the ancestral and the phylogenetically higher organisms.
In our department you can investigate recombinant proteins which play essential role in the construction of the "bacterial cytoskeleton". To do that you are going to learn how to separate your target protein and you get opportunity to investigate it using different biochemical and spectroscopic methods, such as chromatography, photometry, fluorimetry, and high resolution microscopy.
Images: (left) Structure of the actin homologue protein MreB from Thermotoga maritima (PDB ID: 1JCG). (right) Filament system in Caulobacter crescentus.
Supervisor: SZATMÁRI, Dávid
Co-supervisor: Dr. BARKÓ, Szilvia
This Student Researchers’ Topic is a good possibility for students to participate a collaborating project between clinics and basic science researcher lab. Our clinical partner are Prof. Dr. Miklós Koppán, full professor, clinical director and Dr. Szilárd Papp senior clinical lecturer from the Department of Obstetrics and Gynaecology. We are studying expressed and purified actin and p53 apoptotic factor binding proteins effect on shape, division and movement of epidermal cells from cervical cytology samples. In HPV less, infected and treated patients. Mainly, microscopy, cell manipulation and in vitro methods are avaiable to study the malignus transformation of cancer cells on the level of cytoskeletal system.