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Biophysical Basics of Diagnostic and Therapeutic Methods

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Official data in SubjectManager for the following academic year: 2020-2021

Course director

Dr. Gábor HILD (, associate professor

Department of Biophysics

Subject data

Code of subject: OXF-DMB-h-T  |  2 credit  |  General Medicine |  Optional module  |  spring

Prerequisites: ODA-BI2-T completed , ODA-EL2-T completed

Number of hours/semester

0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations

min. 3 – max. 10 person


During the course the students get acquainted with the physical basics of the modern medical diagnostic and therapic methods, from a clinical approach. The aim of the course is to underlie or supplement the clinical knowledge with necessary information. During the seminars, wherever possible, practical demonstrations will also be held.




  • 1. Introduction
  • 2. Classification of the diagnostic methods
  • 3. Radioactive isotopes. Biological effects of ionizing radiations. Radioprotection
  • 4. Isotope therapy (Brachytherapy), radiotherapy
  • 5. Absorption photometry
  • 6. Fluorescence spectroscopy
  • 7. X-ray radiation: production, detection, absorption. Operation of the diagnostic X-ray instrument. Interpret X-ray image
  • 8. Computed tomography. Manipulation of CT-image (windowing, 3D reconstruction, virtual endoscopy)
  • 9. Isotope diagnostics: Gamma camera, SPECT
  • 10. Isotope diagnostics: Positron emission tomography (PET)
  • 11. LASER: features, absorption, effects on biological tissues
  • 12. LASER: dermatological, ophtalmological, surgical applications. Photodynamic therapy
  • 13. Ultrasound: production and physical features
  • 14. Ultrasound: diagnostic and therapeutic applications
  • 15. Basics of flow cytometry and cell sorting
  • 16. Diagnostic applications of flow cytometry
  • 17. Physical basics of magnetic resonance applications. NMR
  • 18. Magnetic resonance imaging (MRI)
  • 19. Measurements on an educational X-ray instrument
  • 20. Measurements on an educational X-ray instrument
  • 21. Computed tomography measurements on an educational CT instrument
  • 22. Computed tomography measurements on an educational CT instrument
  • 23. Test
  • 24. Test

Reading material

Obligatory literature


Literature developed by the Department




Recommended literature

Kane, S.A. Introduction to Physics in Modern Medicine, Taylor&Francis, London, 2003
Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2008

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams


Making up for missed classes


Exam topics/questions



Instructor / tutor of practices and seminars

  • Dr. Hild Gábor
  • Dr. Lukács András Szilárd
  • Dr. Ujfalusi Zoltán