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Evolutionary-developmental Biology of Clinically Relevant Cytoskeletal and Muscle Proteins

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Data

Official data in SubjectManager for the following academic year: 2020-2021

Course director

Dávid SZATMÁRI (david.szatmari@aok.pte.hu), assistant professor

Department of Biophysics

Subject data

Code of subject: OXFSFI-z-T  |  1 credit  |  Dentistry |  Optional module  |  autumn

Prerequisites: -

Number of hours/semester

12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations

min. 4 – max. 40 person

Available as Campus course for 40 student(s). Campus-faculties: ÁOK GYTK TTK

Topic

Since the second part of 20th century many publications interested in a novel issue, that all biologically relevant questions should be answered if we consider as a stage of a developmental process (Richardson et al. 2002, Hall, B. K. 2003, Held et al. 2014). Means the begining of a new science the Evolutionary-Developmental Biology (EVO-DEVO) recently the most developping part of Biology, involves all modern innovations and methods to study genetical, epigenetical regulations and system based thinking about the varieties of gene and cell functions. The aim of this course to introduce the EVO-DEVO to medical students by the description of cytoskeleton and muscular system development and their clinical relevance. Can be a help to extend the perspective and problem solving skills of medical students in their studies and routine. The evolutionary plasticity of stages in different phylogenetical development and their clinically interesting motional and cytoskeletal role will be reviewed during this course.

Lectures

  • 1. Introduction - Dr. Szatmári Dávid Zoltán
  • 2. Evolution - Dr. Hoffmann Gyula
  • 3. Phylogenetic models - Dr. Szatmári Dávid Zoltán
  • 4. Motion and skeletal system of viruses - Dr. Szabó-Meleg Edina
  • 5. Prokaryotic cytoskeletal system I. - Dr. Szatmári Dávid Zoltán
  • 6. Prokaryotic cytoskeletal system II. - Dr. Szatmári Dávid Zoltán
  • 7. Prokaryotic cytoskeletal system III. - Longauer Beáta
  • 8. Eukaryotic cytoskeletal system I. - Türmer Katalin Erzsébet
  • 9. Eukaryotic cytoskeletal system II. - Türmer Katalin Erzsébet
  • 10. Eukaryotic cytoskeletal system III. - Dr. Szatmári Dávid Zoltán
  • 11. Eukaryotic cytoskeletal system IV. - Longauer Beáta
  • 12. Exam - Dr. Szatmári Dávid Zoltán

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

The slides from the lectures we will provide to students on the 11th week.

Notes

Recommended literature

Fejlődésbiológia II. - Epigenetika és fejlődési mintázatképzés (Kronosz Kiadó)
Dr. Hoffmann Gyula - Rauch Tibor - Varga Máté

Richard Dawkins: The Selfish Gene

Evolutionary Developmental Biology. 2nd ed . Hall Brian K. Chapman & Hall, London, 1998. 491 pp. , illus. $ 280.00 (ISBN 0-412-78580-3 cloth ).

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The grade is based on the written test on 12th week, can participate if the number of absences are less then 25%. Students will set in three groups A, B, C and all groups will briefly describe different topics from the list.

Making up for missed classes

No need make up classes. In case of more than 25 % absences students need to register up this course again.

Exam topics/questions

1. Evolutionary thinking, models, pattern formation, bodyplan, brief description
2. Virus, prokaryotes, eukaryotes phylogenetic models, living and nonliving materials, brief description
3. Capsid proteins, selection and plasticity of shape and motion, diseases and zoonosis, brief description
4. Development of bacterial cytoskeletal system, brief description
5. Development of Archaea cytoskeletal system, brief description
6. Pathogenity, resistence, genetical plasticity, quorum sensing, brief description
7. Development of Protozoas motion and cytoskeletal system, parasitology, brief description
8. Development of Plants and Fungi motion and cytoskeletal system, toxicology, brief description
9. Development of Human and Animalia cytoskeletal system, recapitulating diseases, brief description
10. Development of Human and Animalia muscle system, malfunction of muscle genes, brief description

Examiners

Instructor / tutor of practices and seminars