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Education

The Cytoskeletal System

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 12 hours

practices: 0 hours

seminars: 0 hours

total of: 12 hours

Subject data

  • Code of subject: OXFCIR-z-T
  • 1 kredit
  • Dentistry
  • Optional modul
  • autumn
Prerequisites:

-

Course headcount limitations

min. 1 – max. 20

Available as Campus course for 20 fő számára. Campus-karok: ÁOK GYTK TTK

Topic

The cytoskeletal system is composed of different proteins networks. The cytoskeleton has versatile structural and functional features, which are essential for almost all cellular processes. The dysfunctioning of the cytoskeleton can often results in pathological alterations of cellular functions, which can lead to diseases. In the first module the course we discuss the components and properties of the cytoskeletal protein networks. The second module lays special emphasis on presenting the pathological alterations of the cytoskeletal system and the underlying diseases.
I. module: Components and functions of the cytoskeleton.
II. module: Pathological alterations and diseases related to the cytoskeleton.
III. module: Biophysical approaches in the investigation of the cytoskeleton.

Lectures

  • 1. Introduction - Dr. Bugyi Beáta
  • 2. Structure, dynamics and biological functions of cytoskeletal polymers 1 - Dr. Bugyi Beáta
  • 3. Structure, dynamics and biological functions of cytoskeletal polymers 2 - Dr. Bugyi Beáta
  • 4. Cytoskeletal polymers as potential therapeutic targets - Dr. Gaszler Péter
  • 5. Case study: pathogens - Dr. Bugyi Beáta
  • 6. Case study: myopahties - Dr. Bukovics Péter
  • 7. Case study: carcinogenesis - Dr. Gaszler Péter
  • 8. Case study: Actin binding proteins as biomarkers - Dr. Bukovics Péter
  • 9. Case study: Wound healing and tissue regeneration (epidermolysis bullosa simplex) - Dr. Gaszler Péter
  • 10. Case study: Therapeutic approaches targeting the microtubule cytoskeleton - Dr. Bukovics Péter
  • 11. Students’ presentations - Dr. Bugyi Beáta
  • 12. Students’ presentations - Dr. Bugyi Beáta

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Megtalálhatók a Biofizikai Intézet honlapján:
https://aok.pte.hu/hu/egyseg/10/oktatasi-anyagok

Notes

Recommended literature

Jonathon Howard: Mechanics of Motor Proteins and the Cytoskeleton, 2005
S. Trachtenberg: The Prokaryotic Cytoskeleton: A Written Symposium, Journal of Molecular Microbiology and Biotechnology, 2006
Leslie P. Gartner, James L. Hiatt (eds.): Color Textbook of Histology 3, illustrated, revised, Saunders/Elsevier, 2007
Online materials on departmental website (http://biofizika.aok.pte.hu)

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The grading is based on short presentations (5-10 min) by the students related to the topics covered by the course.

Making up for missed classes

None.

Exam topics/questions

Can be found on the departmental website:
https://aok.pte.hu/hu/egyseg/10/oktatasi-anyagok

Examiners

Instructor / tutor of practices and seminars

  • Dr. Bugyi Beáta
  • Dr. Bukovics Péter
  • Dr. Gaszler Péter
Rólunk