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The Human Microbiome: Effects on Disease Development and Prevention

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Data

Official data in SubjectManager for the following academic year: 2020-2021

Course director

Dr. István Zoltán KISS (istvan.kiss@aok.pte.hu), professor

Department of Public Health Medicine

Subject data

Code of subject: OAF-HMB-T  |  2 credit  |  General Medicine |  Optional module  |  both semesters

Prerequisites: -

Number of hours/semester

22 lectures + 0 practices + 2 seminars = total of 24 hours

Course headcount limitations

min. 5 – max. 20 person

Topic

In the human body the number of microbial cells (even according to conservative estimations) is higher than the number of somatic human cells. This microbial ecosystem is distributed across several human organs - even in organs which some decades ago were thought to be sterile.
Recently several articles have been published on the interaction of the microbiome with several physiological/pathophysiological processes (immunity, inflammation, allergy, etc.), and its role in the development of several diseases (e.g. cardiovascular diseases, cancer, asthma, obesity, inflammatory bowel diseases...).
Besides discussing the above mentioned interactions, the course focuses on the role of the human microbiome in disease prevention/therapy. Pharmacological and non-pharmacological possibilities to influence the composition of our microbiome will be discussed, and some futuristic therapeutic approaches (stool transplantation) will also be reviewed.

Lectures

  • 1. The human microbiome. Size, composition, main characteristics. - Dr. Kiss István Zoltán
  • 2. The Human Microbiome Project. - Dr. Kiss István Zoltán
  • 3. The gut microbiome. - Dr. Kiss István Zoltán
  • 4. The skin microbiome. - Dr. Kiss István Zoltán
  • 5. The oral microbiome. The vaginal microbiome. - Dr. Kiss István Zoltán
  • 6. The microbiome of other organs (e.g. lungs, placenta, uterus, urinary tract). - Dr. Kiss István Zoltán
  • 7. The role of microbiome in health and diseases. - Dr. Kiss István Zoltán
  • 8. The role of microbiome in cardiovascular diseases. - Dr. Kiss István Zoltán
  • 9. Microbiome and cancer I. - Dr. Kiss István Zoltán
  • 10. Microbiome and cancer II. - Dr. Kiss István Zoltán
  • 11. Microbiome and immunity. - Dr. Kiss István Zoltán
  • 12. Microbiome and inflammation. - Dr. Kiss István Zoltán
  • 13. Microbiome, allergy, atopia and related diseases. - Dr. Kiss István Zoltán
  • 14. Microbiome and inflammatory bowel diseases. - Dr. Kiss István Zoltán
  • 15. Microbiome and obesity. - Dr. Kiss István Zoltán
  • 16. Microbiome and diabetes. - Dr. Kiss István Zoltán
  • 17. How diet and nutrition affects our microbiome I.? - Dr. Kiss István Zoltán
  • 18. How diet and nutrition affects our microbiome II.? - Dr. Kiss István Zoltán
  • 19. Effects of lifestyle (physical activity, smoking, alcohol etc.) on the microbiome. Can we modify our microbiome? (I.) - Dr. Kiss István Zoltán
  • 20. Effects of lifestyle (physical activity, smoking, alcohol etc.) on the microbiome. Can we modify our microbiome? (II.) - Dr. Kiss István Zoltán
  • 21. Antibiotics, probiotics, prebiotics and our microbiome. - Dr. Kiss István Zoltán
  • 22. Microbiome-related disease prevention strategies. - Dr. Kiss István Zoltán

Practices

Seminars

  • 1. Microbiome-therapy, case studies I.
  • 2. Microbiome-therapy, case studies II.

Reading material

Obligatory literature

Literature developed by the Department

The learning material will be uploaded to Neptun.

Notes

Recommended literature

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Two written multiple choice tests during the semester.

Making up for missed classes

There are no make-up classes.

Exam topics/questions

There is no list of exam questions.

Examiners

Instructor / tutor of practices and seminars

  • Dr. Kiss István Zoltán