Data
Official data in SubjectManager for the following academic year: 2021-2022
Course director
-
Dr. Péter András ENGELMANN
associate professor,
Department of Immunology and Biotechnology -
Number of hours/semester
lectures: 0 hours
practices: 0 hours
seminars: 12 hours
total of: 12 hours
Subject data
- Code of subject: OXF-EVO-h-T
- 1 kredit
- General Medicine
- Optional modul
- autumn
ODA-MB2-T completed , ODA-IMM-T completed
Course headcount limitations
min. 3 – max. 30
Topic
The course describes the molecular and cellular elements of innate/adaptive immunity in their evolutionary contexts. Moreover, it discusses the ancient immune functions (phagocytosis, antimicrobial molecules, antiviral RNA interference) along with the newest research data about the development of adaptive immunity.
Lectures
Practices
Seminars
- 1. Definition of the topics and course, comparison of innate and adaptive immunity
- 2. Pattern recognition receptors: Toll, Croquemort and others
- 3. Conserved signal transduction pathways in immunology
- 4. Cellular immune functions of innate immunity: phagocytosis, cytotoxicity, encapsulation-, capsule-, granulomeformation
- 5. Humoral immune components I: antimicrobial molecules, peptides. Prophenoloxidase cascade, coagulation.
- 6. Humoral immune components II: Acute-phase proteins, complement-evolution
- 7. Humoral immune components III: evolution of cytokines and chemokines
- 8. Sounds of Silence or the role of RNA interference (RNAi) in innate immunity, antiviral innate immunity
- 9. Alternative adaptive immunity in invertebrates and in ancient vertebrates?
- 10. Histoincompatibility in invertebrates, MHC-evolution
- 11. Immunological twilight-zone - The appearance of adaptive immunity, Immunological triumvirate: RAG-time: immunglobulin, TCR development in the context of phylogenesis
- 12. Phylogenetical development of vertebrate immune organs, host-pathogen co-evolution
Reading material
Obligatory literature
Literature developed by the Department
www.immbio.hu
Notes
Recommended literature
http://www.sciencedirect.com/science/journal/0145305X
Conditions for acceptance of the semester
Referral, max. 2 absences from the seminars
Mid-term exams
Presentation
Making up for missed classes
Individual preparation
Exam topics/questions
-
Examiners
Instructor / tutor of practices and seminars
- Dr. Engelmann Péter András