Official data in SubjectManager for the following academic year: 2020-2021
Dr. Géza SÁFRÁNY (firstname.lastname@example.org), visiting professor
Institute of Laboratory Medicine
Code of subject: OAF-SUB-T | 2 credit | General Medicine | Optional module | spring
12 lectures + 0 practices + 12 seminars = total of 24 hours
min. 3 – max. 30 person
Available as Campus course for 30 student(s). Campus-faculties: ÁOK ÁJK BTK ETK KPVK GYTK KTK MK MIK TTK
The course will focus on the better understanding of radiation effects on the whole organisms, tissues and cells, as well as on the cellular causes leading to the death of normal and malignant cells. This helps to understand why a given dose of radiation induces tumors in one case while destroys tumor cells in another case. On the basis of radiobiological knowledge one can develop new therapeutic modalities to improve the survival of cancer patients. Radiation biology helps us to understand how and why ionizing radiation can be used to examine healthy and pathological cell structures and to diagnose and treat various diseases.
The aim of radiation therapy is to kill tumor cells without seriously damaging normal tissues. The death of normal cells leading to the development of early and late normal tissue sequels strongly influences the amount of total and fraction doses deliverable to the malignant tissues and by this way the success of radiation therapy. We will describe factors and protocols affecting and suitable to predict radiation-induced reactions in healthy and malignant cells. The effect of dose rate, total- and fraction dose, as well as treatment time on the radiation response of normal and tumor cells will be discussed, too. We will describe in details those new radiotherapy approaches (accelerated-, hyper-fractionated, etc. radiotherapy) which were developed on radiobiological backgrounds. We will discuss those new therapeutic modalities such as gene therapy which can be efficiently combined with radiation therapy. Using up to date methodologies the radiation sensitivity of normal and malignant tissues might be predicted before the onset of radiation therapy and radiation regimens can be adjusted to individual needs. This can improve the survival chances of tumor patients.
Finally, we will discuss the radiation protection measures necessary to minimize the damaging effect of ionizing radiation.
Radiation Biology: A Handbook for Teachers and Students. International Atomic Energy Agency, Vienna, 2010; http://www.iaea.org/books
In the case of maximum 2 unexcused absences the student is allowed to take the exam.
Test exam at the end of the course; oral consultation at halfway
Joining later seminars, individual consultations.
Multiple choice test for checking the acquisition of course material is given at the end of semester. Questions include material discussed in lectures and seminars. It is important to know that part of the material cannot be found in textbooks.