Transfusion Course for Graduate Students

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

The course is a graduate version of the former postgradual course about blood transfusion. During the course the theoretical and practical basics necessary to deliver a transfusion therapy in a safe manner and to diagnose the complications of transfusion will be provided. The covered topics will include the clinically significant blood groups, the various types of blood products available, rules regarding their storage and transportation. During practices students will be trained in blood grouping, interpretation of laboratory blood typing and antibody screening test results, and macroscopic examination of the blood products. Having completed their successful exam in Hungary, resident doctors have to become familiar with the rules of blood transfusion in the actual state and local hospital, where they work, prior to performing transfusions.

Lectures

• 1. Presentation of the course, short history of transfusion medicine - Dr. Pál Sándor
• 2. Immunology and transfusion medicine - Dr. Pál Sándor
• 3. ABO blood groups  and their clinical significance - Dr. Pászthy Vera
• 4. ABO blood groups  and their clinical significance - Dr. Pászthy Vera
• 5. Rh and other clinically significant blood groups. Obligatory blood group examinations before transfusion. - Dr. Pászthy Vera
• 6. Clinical significance of platelet, granulocyte and HLA antigen systems - Dr. Pál Sándor
• 7. Preparation of labile blood products  from whole blood. Various types, characteristics and labeling of blood products. Rules of storage and transport. - Dr. Csernus Zita
• 8. Preparation of labile blood products  from whole blood. Various types, characteristics and labeling of blood products. Rules of storage and transport. - Dr. Csernus Zita
• 9. Indication of transfusion (RBC, thrombocyte) Guidelines of RBC and thrombocyte replacement. Control of transfusion efficacy, methods - Dr. Pál Sándor
• 10. Indications of leucoreduced, washed, irradiated blood products. Algorithm of blood product selection - Dr. Pál Sándor
• 11. Description of plasma derivatives (factor products, albumin, IVIG), indications. Indication of FFP administration - Dr. Pál Sándor
• 12. Pre-transfusion tasks. Documentation system of transfusion - Dr. Pál Sándor
• 13. Hungarian guide of transfusion-related activity. Importance of patient identification during transfusion-related activity - Dr. Pál Sándor
• 14. Transfusion related regulations. - Dr. Csernus Zita
• 15. Adverse effects of transfusion: immunological, haemolytic and non haemolityc transfusion related complications - Dr. Faust Zsuzsanna
• 16. Adverse effects of transfusion: non immunological transfusion-related complications (circulatory- and iron overload) - Dr. Faust Zsuzsanna
• 17. Adverse effects of transfusion and their treatment - Dr. Csontos Csaba
• 18. Transfusion transmitted infections, epidemiology, screening, prevention (HIV, HBV, HCV - Dr. Pászthy Vera
• 19. Definition of compatibility. Immuno-haematological rules of selecting blood products. Interpretation of blood group serological results. Tranfusiological concilium - Dr. Csernus Zita
• 20. Definition of compatibility. Immuno-haematological rules of selecting blood products. Interpretation of blood group serological results. Tranfusiological concilium - Dr. Csernus Zita
• 21. The structure of hungarian blood supply, blood management in the blood transfusion service and bedside. Organisation of blood donation in the clinic. Conditions of directed blood donation - Dr. Pászthy Vera
• 22. Patient blood management program - Dr. Pál Sándor
• 23. The clinical physiology, pathophysiology, age-related and physiologycal modifications of haemostasis. Drugs acting on haemostasis (pro and anti). - Dr. Alizadeh Hussain
• 24. Basics of perioperative haemostasis. Targeted hemosubstitution controlled by viscoelastic tests (TEG/ROTEM). Management of acute bleeding. Protocol of massive transfusion - Dr. Faust Zsuzsanna
• 25. Surgical techniques of haemostasis. Blood saver techniques (application fields, limits). - Dr. Szabados Sándor
• 26. Principles of shock therapy. Basics of volume therapy and therapeutic devices/products. Indications of transfusion in intensive care and anaesthesiology - Dr. Csontos Csaba
• 27. Treatment of acquired haemophilic conditions (antithrombotics, thrombocyte aggregation inhibitors, anticoagulant – related bleedings) - Dr. Nagy Ágnes
• 28. Inherited hemophilias: causes, therapeutic possibilities, perioperative management - Dr. Nagy Ágnes
• 29. Hematopoetic stem cell transplantation (donor organisation, Bone Marrow Registry, cord blood bank) Blood product requirements of organ transplantation - Dr. Szomor Árpád
• 30. Consultation - Dr. Csernus Zita

Practices

• 1. ABO blood grouping: forward and reverse grouping, Identification of the patient and the sample.
• 2. ABO blood grouping: forward and reverse grouping, Identification of the patient and the sample.
• 3. RhD blood grouping, practice of ABO blood grouping, Bedside test
• 4. RhD blood grouping, practice of ABO blood grouping, Bedside test
• 5. Demonstration of blood products, rules of labeling, macroscopic examination of blood products before transfusion
• 6. Demonstration of blood products, rules of labeling, macroscopic examination of blood products before transfusion
• 7. Principels of compatibility, practice of blood typing (ABO, RhD typing with laboratory method and Bedside test)
• 8. Principels of compatibility, practice of blood typing (ABO, RhD typing with laboratory method and Bedside test)

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Notes

Recommended literature

Harvey G. Klein, David J. Anstee
Mollison's Blood Transfusion in Clinical Medicine, 12th Edition

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Attending the lectures and practices is obligatory. Absences up to 15% are accepted.
Participation in 3 transfusions.

Making up for missed classes

If someone misses a practice for any reason, he/she is asked to attend the practice in question given to another group.

Exam topics/questions

Written test and practical exam

Examiners

Instructor / tutor of practices and seminars

• Dr. Csernus Zita
• Dr. Pászthy Vera