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BALASKÓ, Márta

BALASKÓ, Márta

PhD

associate professor , vice chair

Institute for Translational Medicine

Telefon: 30102, 31545

Course director - English Program

Excellent practice instructor
2018, 2017, 2015, 2014

Supervisor of the following TDK topics

Supervisor: BALASKÓ, Márta

Co-supervisor: Dr. PÉTERVÁRI, Erika

Cholecystokinin administered peripherally or centrally elicits anorexigenic effects, but its complex peripheral or central catabolic effects may be divergent. In the periphery, the role of CCK1- receptors may be dominant, in the brain, CCK acts mainly via CCK2 receptors, but overlaps may occur. We plan to clarify the the role of CCK1 and CCK2 receptors in the development of anorexigenic and metabolic effects via the peripheral and central application of specific CCK1 and CCK2 receptor antagonists. Acute (intraperitoneal/intracerebroventricular) injections and similar chronic infusions will be applied using biotelemetry and indirect calorimetry. Our previous results show, that CCK-effects depend on age and nutritional state, so the above outlined experiments will be carried out in different age-groups of rats characterized by different nutritional states.

Supervisor: BALASKÓ, Márta

Obstructive lung diseases affect more and more people worldwide. The symptoms of these diseases grow more severe during aging leading to a decline in the quality of life. The aim of the research is to study the effects of different diets/nutritional states and those of physical training on the symptoms of obstructive lung diseases in men and women.

Supervisor: BALASKÓ, Márta

Age-related regulatory alterations may be assumed in the background of middle-aged obesity and aging anorexia since they also appear in other mammals. Our previous studies described such regulatory alterations of the central catabolic melanocortin system: a weak catabolic responsiveness to alpha-melanocyte stimulating hormone in middle-aged and a strong one in old age-groups. Corticotropin releasing factor (CRF) and urocortins are important catabolic peptide mediators downstream to the melanocortins. Their effects are mediated by CRF1 and CRF2 receptors. In the PhD program we aim to investigate the age- and nutritional state-associated alterations in the central corticotropin system (and those of its receptors). Animal experiments will carried out in different age-groups (from juvenile to old) of laboratory rodents. Regarding nutritional state, we establish ad libitum fed, diet-induced obese and calorie-restricted groups withing the age-groups. During the analysis of central acute and chronic corticotropin responsiveness, food intake is to be recorded in an automated FeedScale system, circadian rhythm of core temperature, heart rate, spontaneous locomotor activity in a biotelemetric system (MiniMitter, Respironics). These measurements will be complemented by the registration of oxygen consumption, core and tail skin temperature (the latter indicates heat loss) in an Oxymax system (Columbus) for indirect calorimetry.