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SOLYMÁR, Margit

SOLYMÁR, Margit

Ph.D.

Telefon: 30103

Supervisor of the following TDK topics

Supervisor: SOLYMÁR, Margit

The obesity epidemic is one of the most serious public health challenges in the European region: more than one in two adults is overweight or obese. Obesity is the basis for the development of major non-infectious diseases (such as metabolic syndrome, hypertension, insulin resistance, type 2 diabetes mellitus, dyslipidemia, subsequent pathological vascular changes and atherosclerosis). Therefore, obesity reduces life expectancy and reduces quality of life.
In the background of cardiovascular complications, endothelial dysfunction develops before the development of atherosclerosis. The chronic inflammatory state of obesity causes poor control of the endocrine and paracrine effects of adipocyte-derived factors, which disrupts vascular homeostasis and contributes to the disruption of endothelial vasodilatory effects and subsequent hypertension. In our experiments, we aim to observe, reverse and prevent abnormal vascular functions after obesity caused by high-fat diet and in type 1 and type 2 diabetes mellitus with a novel therapeutic approach by activating the PAC1, VPAC1 and VPAC2 receptors.

Supervisor: SOLYMÁR, Margit

The obesity epidemic is one of the most serious public health challenges in the European region: more than one in two adults is overweight or obese. Obesity is the basis for the development of major non-infectious diseases (such as metabolic syndrome, hypertension, insulin resistance, type 2 diabetes mellitus, dyslipidemia, subsequent pathological vascular changes and atherosclerosis). Therefore, obesity reduces life expectancy and reduces quality of life.
In the background of cardiovascular complications, endothelial dysfunction develops before the development of atherosclerosis. The chronic inflammatory state of obesity causes poor control of the endocrine and paracrine effects of adipocyte-derived factors, which disrupts vascular homeostasis and contributes to the disruption of endothelial vasodilatory effects and subsequent hypertension. In our experiments, we aim to observe, reverse and prevent abnormal vascular functions after obesity caused by high-fat diet and in type 1 and type 2 diabetes mellitus with a novel therapeutic approach by activating the PAC1, VPAC1 and VPAC2 receptors.