Telefon: 31881, 30103
Course director - German Program, Gerontology Research Group leader
Supervisor: BALASKÓ, Márta
Co-supervisor: Dr. PÉTERVÁRI, Erika
Cholecystokinin administered peripherally or centrally elicits anorexigenic effects, but its complex peripheral or central catabolic effects may be divergent. In the periphery, the role of CCK1- receptors may be dominant, in the brain, CCK acts mainly via CCK2 receptors, but overlaps may occur. We plan to clarify the the role of CCK1 and CCK2 receptors in the development of anorexigenic and metabolic effects via the peripheral and central application of specific CCK1 and CCK2 receptor antagonists. Acute (intraperitoneal/intracerebroventricular) injections and similar chronic infusions will be applied using biotelemetry and indirect calorimetry. Our previous results show, that CCK-effects depend on age and nutritional state, so the above outlined experiments will be carried out in different age-groups of rats characterized by different nutritional states.