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SZAKÁCS, Zsolt

SZAKÁCS, Zsolt

Telefon: 30104

PhD training Coordinator

Supervisor of the following TDK topics

Supervisor: PÁRNICZKY, Andrea

Co-supervisor: Dr. SZAKÁCS, Zsolt

Cystic fibrosis (CF) is caused by a loss of function mutation in the CFTR chloride channel (most commonly deltaF508), which causes abnormalities in the function of the external glands. It is a complex disorder that is mainly associated with severe respiratory and digestive symptoms and usually affects the pancreas as well. Pancreatic parenchymal damage may occur early in life, even in utero, leading to the development of cystic fibrosis-related diabetes (CFRD). The disease, in addition to other rare causes of diabetes, is classified as type 3 diabetes mellitus.

In this topic, we will perform a meta-analysis to investigate methods used to diagnose CFRD. The purpose of the diagnostic test accuracy meta-analysis is to compare different modalities to each other, thereby ranking them. According to current guidelines, the gold standard diagnostic test is the oral glucose tolerance test (OGTT), but several other modalities are available (e.g., continuous glucose monitoring, fasting blood glucose levels and haemoglobin A1C). Our results can contribute to the selection of the best (and most cost-effective) diagnostic option.

Supervisor: SZAKÁCS, Zsolt

Co-supervisor: Dr. BAJOR, Judit

Celiac disease is an immune-mediated disorder, which affects approximately 1% of the population. The altered immune response is the consequence of the interplay of genetic (HLA-haplotypes) and environmental exposures (that is, the ingestion of gluten). The disease has several intestinal and extraintestinal signs and symptoms, the latter group includes metabolic bone disease. The pathophysiological background of osteoporosis and osteopenia is rather complex: both the exposure to chronic systemic inflammation and the malabsorption with the consequent calcium and vitamin D deficiency are important contributors. The single known effective therapy is the lifelong deprivation of gluten (i.e., gluten-free diet).

Whether metabolic bone disease is reversible with adequate gluten-free diet has remained controversial. The aim of the research topic is to perform a meta-analysis, in which we assess bone mineral density at the time of diagnosis and later on gluten-free diet to determine the change both in children and adults. The findings may contribute to the establish the indication of DEXA-scans with effective timing.

Supervisor: SZAKÁCS, Zsolt

Co-supervisor: Dr. BAJOR, Judit

The diagnosis of celiac disease is sometimes challenging. In addition to the extraordinary variability in clinical presentation, severe intestinal and extraintestinal symptoms and accompanying diseases may develop. Some patients complain of typical gastrointestinal symptoms whereas others exhibit an atypical presentation (Oslo classification). The phenotype is often complicated by the development of autoimmune diseases and celiac complications. It is not clear how factors determine the clinical phenotype. The degree of small intestinal damage does not provide a satisfactory explanation for a phenomenon describing that patients may suffer from severe malabsorption or be asymptomatic with total villous atrophy.

In this project, we focus on the clinical phenotype of celiac disease by approaching the diverse disease course from different aspects. Concomitant diseases (especially the autoimmune diseases) and special subclinical alterations predisposing to higher complication rates, e.g., the association between hemorrheological parameters and the increased risk of thrombosis, are in the focus of interest.

Supervisor: SZAKÁCS, Zsolt

Co-supervisor: Dr. PÁRNICZKY, Andrea

Cystic fibrosis (CF) is caused by a loss of function mutation in the CFTR chloride channel (most commonly deltaF508), which causes abnormalities in the function of the external glands. It is a complex disorder that is mainly associated with severe respiratory and digestive symptoms. In CF patients, the lungs become more susceptible to bacterial infections and may sustain chronic lung injury, leading to respiratory failure and even to death.

In the study, we use the Hungarian CF Registry to investigate the relationship between the clinical picture and microbiological profile of CF-associated lung injury. The aim of the research is to evaluate the microbiological and clinical features of the Hungarian CF population with statistical analysis. Results can contribute to the improvement of patient’s quality of life and medical attendance.