Supervisor: GARAMI, András
Co-supervisor: Dr. RUMBUS, Zoltán
Systemic inflammation of the body (e.g., sepsis) is the 10th most common cause of death in the world, demanding approx. 1400 lives daily. In Hungary, ~9000 patients are treated in intensive care units because of sepsis with a mortality rate of 30-60%. Systemic inflammation is strongly associated with changes of body temperature, which is also included in its clinical diagnosis. Most patients have fever, but many develop a body temperature lower than normal (hypothermia). For the successful intensive therapy and for the reduction of the mortality rate of systemic inflammation, it is inevitable to carefully explore the involved physiological and pathological mechanisms, which are still subjects of research.