Pharmaceutical Chemistry 1 - Theory

Data

Official data in SubjectManager for the following academic year: 2020-2021

Course director

Number of hours/semester

lectures: 28 hours

practices: 0 hours

seminars: 0 hours

total of: 28 hours

Subject data

  • Code of subject: OPG-R1E-T
  • 2 kredit
  • Pharmacy
  • Pharm. theoretical module and practical skills modul
  • autumn
Prerequisites:

OPA-P2E-T completed , OPA-S2E-T completed , OPG-R1G-T parallel

Exam course:

yes

Course headcount limitations

min. 5 – max. 20

Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.

Lectures

  • 1. Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances. - Dr. Perjési Pál
  • 2. Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances. - Dr. Perjési Pál
  • 3. Physical and physicochemical methods of the European Pharmacopoeia. - Dr. Kulcsár Győző Kornél
  • 4. Identification and qualitative tests of the European Pharmacopoeia. - Dr. Kulcsár Győző Kornél
  • 5. Protein-specific test methods of the European Pharmacopoeia. - Dr. Perjési Pál
  • 6. Protein-specific test methods of the European Pharmacopoeia. - Dr. Perjési Pál
  • 7. The fate of xenobiotics in the body. The receptor theory. - Dr. Perjési Pál
  • 8. The fate of xenobiotics in the body. The receptor theory. - Dr. Perjési Pál
  • 9. Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions. - Dr. Perjési Pál
  • 10. Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions. - Dr. Perjési Pál
  • 11. Structural and physical chemical basis of drug action. Structure-activity relationships. - Dr. Perjési Pál
  • 12. Structural and physical chemical basis of drug action. Structure-activity relationships. - Dr. Perjési Pál
  • 13. Transport processes. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
  • 14. Transport processes. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
  • 15. Central and peripheral receptors. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
  • 16. Central and peripheral receptors. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
  • 17. Structure and functions of enzymes. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
  • 18. Structure and functions of enzymes. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
  • 19. Phase 1 metabolic transformations. - Dr. Almási Attila
  • 20. Phase 1 metabolic transformations. - Dr. Almási Attila
  • 21. Phase 2 metabolic transformations. - Dr. Almási Attila
  • 22. Phase 2 metabolic transformations. - Dr. Almási Attila
  • 23. Drug metabolism and drug toxicity. - Dr. Perjési Pál
  • 24. Drug metabolism and drug toxicity. - Dr. Perjési Pál
  • 25. General anesthetics. - Dr. Huber Imre
  • 26. General anesthetics. - Dr. Huber Imre
  • 27. Narcotic analgesics. - Dr. Huber Imre
  • 28. Narcotic analgesics. - Dr. Huber Imre

Practices

Seminars

Reading material

Obligatory literature

D. A. Williams, T. L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Literature developed by the Department

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic educational material, PTE 2014
Zsuzsanna Rozmer, Pál Perjési: Physico-Chemical Bases of Drug Action. Electronic educational material, PTE 2015

Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015

Recommended literature

European Pharmacopoeia, EDQM Publication
Lecture notes.

Conditions for acceptance of the semester

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two compulsory midterm tests (on the topics of the lectures and practices) will be written during the semester on the 7th and the 12th weeks. Both of the test result should be above 60%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.

Making up for missed classes

There is no opportunity to make up missed classes.

Exam topics/questions

Written exam covering the topics of the lectures and the laboratory practices. The result of the first part of the written exam (Minimum Written Test) should be at least 80%. In the case of the third ("C") exam the written exam is evaluated regardless the result of the Minimum Written Test. The list of the possible questions of the Minimum Written Test is announced on the Neptun system. The result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is compulsory.

Examiners

  • Dr. Almási Attila
  • Dr. Huber Imre
  • Dr. Perjési Pál

Instructor / tutor of practices and seminars