Inorganic Pharmaceutical Chemistry - Practice

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The aim of the course is acquiring the basis of modern inorganic chemistry with adaptation of the principles to understand the physical and chemical properties of the most important pharmacy-related elements and inorganic compounds. The subject devotes special attention to the inorganic compounds (active pharmaceutical ingredients and excipients) listed in the Pharmacopoeia. The practices provide the experimental background of these educational goals.

Lectures

Practices

• 1. Laboratory safety. Introduction and handover of laboratory equipment. Basic principles. Classification of matter. Naming simple compounds: Acids, bases and salts. Weighing.
• 2. Laboratory safety. Introduction and handover of laboratory equipment. Basic principles. Classification of matter. Naming simple compounds: Acids, bases and salts. Weighing.
• 3. Laboratory safety. Introduction and handover of laboratory equipment. Basic principles. Classification of matter. Naming simple compounds: Acids, bases and salts. Weighing.
• 4. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 5. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 6. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 7. Basic principles of calculations II: Concentrations. Purification of inorganic compounds I.: Decantation, Filtration. Recrystallisation. Purification of alum by recrystallisation I, Dilution of solutions.
• 8. Basic principles of calculations II: Concentrations. Purification of inorganic compounds I.: Decantation, Filtration. Recrystallisation. Purification of alum by recrystallisation I, Dilution of solutions.
• 9. Basic principles of calculations II: Concentrations. Purification of inorganic compounds I.: Decantation, Filtration. Recrystallisation. Purification of alum by recrystallisation I, Dilution of solutions.
• 10. Basic principles of calculations III: Concentrations. Purification of inorganic compounds II.: Destillation, Sublimation.
• 11. Basic principles of calculations III: Concentrations. Purification of inorganic compounds II.: Destillation, Sublimation.
• 12. Basic principles of calculations III: Concentrations. Purification of inorganic compounds II.: Destillation, Sublimation.
• 13. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Extraction.
• 14. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Extraction.
• 15. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Extraction.
• 16. Basic thermodynamics. Hess's law. Observation of thermal decompositions. Determination of melting point. Determination.
• 17. Basic thermodynamics. Hess's law. Observation of thermal decompositions. Determination of melting point. Determination.
• 18. Basic thermodynamics. Hess's law. Observation of thermal decompositions. Determination of melting point. Determination.
• 19. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 20. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 21. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 22. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I., Preparation of potassium dihydrogenphosphate I.
• 23. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I., Preparation of potassium dihydrogenphosphate I.
• 24. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I., Preparation of potassium dihydrogenphosphate I.
• 25. Acid-base equilibrium I. Hydrolysis of ions. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 26. Acid-base equilibrium I. Hydrolysis of ions. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 27. Acid-base equilibrium I. Hydrolysis of ions. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 28. Acid-base equilibrium II. Arrhenius concept, Brönsted-Lowry concept, Lewis concept.
• 29. Acid-base equilibrium II. Arrhenius concept, Brönsted-Lowry concept, Lewis concept.
• 30. Acid-base equilibrium II. Arrhenius concept, Brönsted-Lowry concept, Lewis concept.
• 31. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 32. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 33. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 34. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 35. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 36. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 37. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 38. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 39. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 40. Characterisation of complexes. Stability constants. Return of laboratory utensilis.
• 41. Characterisation of complexes. Stability constants. Return of laboratory utensilis.
• 42. Characterisation of complexes. Stability constants. Return of laboratory utensilis.

Seminars

Reading material

Obligatory literature

Ebbing D.D., Gammon S.D.: General Chemistry, 9th edition, Houghton Miffin Co., Boston, 2009

Literature developed by the Department

Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices. University of Pécs, 2014. Electronic educational material,
Huber I: Inorganic Pharmaceutical Chemistry I. University of Pécs, 2019. Electronic educational material

Notes

Recommended literature

en.wikobooks.org/wiki/General_Chemistry

Conditions for acceptance of the semester

Acknowledgment of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory. Maximum three absences can be accepted. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgment of the semester.

Mid-term exams

Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgment of the semester.

Making up for missed classes

There is no opportunity to make up missed classes (lectures and practices).

Exam topics/questions

N/A

Examiners

Instructor / tutor of practices and seminars

• Dr. Fatemeh KENARI
• Dr. Almási Attila
• Dr. Kulcsár Győző Kornél
• Dr. Perjési Pál
• Fülöpné Dr. Kiss Edit