Pharmaceutical Chemistry 1

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic substances. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.

Lectures

• 1. Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances. - Dr. Perjési Pál
• 2. Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances. - Dr. Perjési Pál
• 3. Physical and physicochemical methods of the European Pharmacopoeia. Identification and qualitative tests of the European Pharmacopoeia. - Dr. Kulcsár Győző Kornél
• 4. Physical and physicochemical methods of the European Pharmacopoeia. Identification and qualitative tests of the European Pharmacopoeia. - Dr. Kulcsár Győző Kornél
• 5. Protein-specific test methods of the European Pharmacopoeia. - Dr. Perjési Pál
• 6. Protein-specific test methods of the European Pharmacopoeia. - Dr. Perjési Pál
• 7. The fate of xenobiotics in the body. The receptor theory. - Dr. Perjési Pál
• 8. The fate of xenobiotics in the body. The receptor theory. - Dr. Perjési Pál
• 9. Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions. - Dr. Perjési Pál
• 10. Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions. - Dr. Perjési Pál
• 11. Structural and physical chemical basis of drug action. Structure-activity relationships. - Dr. Perjési Pál
• 12. Structural and physical chemical basis of drug action. Structure-activity relationships. - Dr. Perjési Pál
• 13. Transport processes. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
• 14. Transport processes. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
• 15. Central and peripheral receptors. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
• 16. Central and peripheral receptors. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
• 17. Structure and functions of enzymes. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
• 18. Structure and functions of enzymes. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
• 19. Phase 1 metabolic transformations. - Dr. Almási Attila
• 20. Phase 1 metabolic transformations. - Dr. Almási Attila
• 21. Phase 2 metabolic transformations. - Dr. Almási Attila
• 22. Phase 2 metabolic transformations. - Dr. Almási Attila
• 23. Drug metabolism and drug toxicity. - Dr. Perjési Pál
• 24. Drug metabolism and drug toxicity. - Dr. Perjési Pál
• 25. General anesthetics. - Dr. Huber Imre
• 26. General anesthetics. - Dr. Huber Imre
• 27. Narcotic analgesics. - Dr. Huber Imre
• 28. Narcotic analgesics. - Dr. Huber Imre

Practices

• 1. Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.
• 2. Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.
• 3. Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.
• 4. Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.
• 5. Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.
• 6. Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.
• 7. Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.
• 8. Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.
• 9. Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.
• 10. Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.oridum.
• 11. Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.
• 12. Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.
• 13. Inorganic pharmacopoeial substances II. Oxygen group. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.
• 14. Inorganic pharmacopoeial substances II. Oxygen group. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.
• 15. Inorganic pharmacopoeial substances II. Oxygen group. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.
• 16. Inorganic pharmacopoeial substances II. Oxygen group. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.
• 17. Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum.
• 18. Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum.
• 19. Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum.
• 20. Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum.
• 21. Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi subnitras.
• 22. Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi subnitras.
• 23. Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi subnitras.
• 24. Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi subnitras.
• 25. 1st Midterm Test. Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas.
• 26. 1st Midterm Test. Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas.
• 27. 1st Midterm Test. Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas.
• 28. 1st Midterm Test. Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas.
• 29. Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.
• 30. Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.
• 31. Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.
• 32. Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.
• 33. Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).
• 34. Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).
• 35. Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).
• 36. Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).
• 37. Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Earth metals. Silicon compounds. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum, Magnesii trisilicas, Silica, colloidal hydrated, Acidum boricum, Borax.
• 38. Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Earth metals. Silicon compounds. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum, Magnesii trisilicas, Silica, colloidal hydrated, Acidum boricum, Borax.
• 39. Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Earth metals. Silicon compounds. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum, Magnesii trisilicas, Silica, colloidal hydrated, Acidum boricum, Borax.
• 40. Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Earth metals. Silicon compounds. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum, Magnesii trisilicas, Silica, colloidal hydrated, Acidum boricum, Borax.
• 41. Inorganic pharmacopoeial substances IX. Metals. Aluminii oxidum hydricum, Aluminii sulfas, Zinci oxydum, Zinci chloridum, Ferrosi sulfas, Kalii permanganas.
• 42. Inorganic pharmacopoeial substances IX. Metals. Aluminii oxidum hydricum, Aluminii sulfas, Zinci oxydum, Zinci chloridum, Ferrosi sulfas, Kalii permanganas.
• 43. Inorganic pharmacopoeial substances IX. Metals. Aluminii oxidum hydricum, Aluminii sulfas, Zinci oxydum, Zinci chloridum, Ferrosi sulfas, Kalii permanganas.
• 44. Inorganic pharmacopoeial substances IX. Metals. Aluminii oxidum hydricum, Aluminii sulfas, Zinci oxydum, Zinci chloridum, Ferrosi sulfas, Kalii permanganas.
• 45. Physico-chemical parameters influencing the biological effect (solubility, pKa, logP). Determination of logP.
• 46. Physico-chemical parameters influencing the biological effect (solubility, pKa, logP). Determination of logP.
• 47. Physico-chemical parameters influencing the biological effect (solubility, pKa, logP). Determination of logP.
• 48. Physico-chemical parameters influencing the biological effect (solubility, pKa, logP). Determination of logP.
• 49. Classification of functional groups and heterocycles (seminar).
• 50. Classification of functional groups and heterocycles (seminar).
• 51. Classification of functional groups and heterocycles (seminar).
• 52. Classification of functional groups and heterocycles (seminar).
• 53. Basics of stereochemistry. Stereochemistry of morphine and derivatives.
• 54. Basics of stereochemistry. Stereochemistry of morphine and derivatives.
• 55. Basics of stereochemistry. Stereochemistry of morphine and derivatives.
• 56. Basics of stereochemistry. Stereochemistry of morphine and derivatives.

Seminars

Reading material

Obligatory literature

D. A. Williams, T. L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Literature developed by the Department

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015

Recommended literature

European Pharmacopoeia, EDQM Publication.
Lecture notes.

Conditions for acceptance of the semester

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the practices is obligatory. Maximum three absences can be accepted both from lectures and practices. There is an obligation to write two midterm tests (week 7. and 12.) from the topics of „theory” and „practice”. Students must reach the minimum level of 60% in both cases. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.

Making up for missed classes

There is no opportunity to make up missed classes.

Exam topics/questions

Written exam covering the topics of the lectures and the laboratory practices. The result of the first part of the written exam (Minimum Written Test) should be at least 80%. In the case of the third ("C") exam the written exam is evaluated regardless the result of the Minimum Written Test. The list of the possible questions of the Minimum Written Test is announced on the Neptun system. The result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is compulsory.

Examiners

• Dr. Almási Attila
• Dr. Huber Imre
• Dr. Perjési Pál

Instructor / tutor of practices and seminars

• Dr. Almási Attila