Basics of Stereochemistry

Data

Official data in SubjectManager for the following academic year: 2021-2022

Course director

Number of hours/semester

lectures: 14 hours

practices: 0 hours

seminars: 0 hours

total of: 14 hours

Subject data

  • Code of subject: OPE-STK-T
  • 1 kredit
  • Pharmacy
  • Elective modul
  • spring
Prerequisites:

OPA-S2E-T completed , OPG-R1E-T completed , OPO-GE2-T completed

Course headcount limitations

min. 5 – max. 15

Topic

In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their place of biological action.

Lectures

  • 1. Introduction, confoguration, conformation definitions. - Dr. Huber Imre
  • 2. Chirality, asymmetry. - Dr. Huber Imre
  • 3. Asymmetric syntheses - Dr. Huber Imre
  • 4. Fischer projection, CIP system. - Dr. Huber Imre
  • 5. Diastereomers, enantiomers. - Dr. Huber Imre
  • 6. Epimers, eutomers, distomers. - Dr. Huber Imre
  • 7. Homochirality, inversion, meso-isomers. - Dr. Huber Imre
  • 8. Newman projection. - Dr. Huber Imre
  • 9. Optical purity. - Dr. Huber Imre
  • 10. Prochirality, prostereoisomerism. - Dr. Huber Imre
  • 11. Racemate, racemisation. - Dr. Huber Imre
  • 12. Retention in stereochemistry. - Dr. Huber Imre
  • 13. Stereoselectivity, stereospecificity. - Dr. Huber Imre
  • 14. Summary, written test. - Dr. Huber Imre

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Lecture notes provided by the lecturer.

Notes

Lecture notes provided by the lecturer.

Recommended literature

K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Students will have to write a written test at the end of the semester.

Making up for missed classes

In case of absences the students must follow up with self-education!

Exam topics/questions

These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the corresponding answers, parallely.

Examiners

Instructor / tutor of practices and seminars