Inorganic Pharmaceutical Chemistry - Practice

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

The aim of the course is acquiring the basis of modern inorganic chemistry with adaptation of the principles to understand the physical and chemical properties of the most important pharmacy-related elements and inorganic compounds. The subject devotes special attention to the inorganic compounds (active pharmaceutical ingredients and excipients) listed in the Pharmacopoeia. The practices provide the experimental background of these educational goals.

Lectures

Practices

• 1. Laboratory safety. Introduction and handover of laboratory equipment. Weighing.
• 2. Laboratory safety. Introduction and handover of laboratory equipment. Weighing.
• 3. Laboratory safety. Introduction and handover of laboratory equipment. Weighing.
• 4. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 5. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 6. Basic principles of calculations I: Concentrations. Delivering liquids. Preparation of solutions. Measuring density.
• 7. Basic principles of calculations II: Dilutions. Purification of inorganic compounds I. Decantation, Filtration. Recrystallization. Purification of alum by recrystallization I.
• 8. Basic principles of calculations II: Dilutions. Purification of inorganic compounds I. Decantation, Filtration. Recrystallization. Purification of alum by recrystallization I.
• 9. Basic principles of calculations II: Dilutions. Purification of inorganic compounds I. Decantation, Filtration. Recrystallization. Purification of alum by recrystallization I.
• 10. Basic principles of calculations III: Crystallization. Purification of inorganic compounds II.: Destillation, Sublimation. Purification of alum II. Determination of % composition of contaminated calcium carbonate.
• 11. Basic principles of calculations III: Crystallization. Purification of inorganic compounds II.: Destillation, Sublimation. Purification of alum II. Determination of % composition of contaminated calcium carbonate.
• 12. Basic principles of calculations III: Crystallization. Purification of inorganic compounds II.: Destillation, Sublimation. Purification of alum II. Determination of % composition of contaminated calcium carbonate.
• 13. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Separation of iodine by sublimation. Separation of iodine by extraction.
• 14. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Separation of iodine by sublimation. Separation of iodine by extraction.
• 15. Basic principles of calculations IV: Stochiometry. Purification of inorganic compounds III. Desalination of water. Separation of iodine by sublimation. Separation of iodine by extraction.
• 16. Observation of thermal decompositions. Determination of melting point. Determination of boiling point.
• 17. Observation of thermal decompositions. Determination of melting point. Determination of boiling point.
• 18. Observation of thermal decompositions. Determination of melting point. Determination of boiling point.
• 19. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 20. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 21. Basic principles of chemical kinetics. Observation of reaction rates. Landolt-reaction. Oscillating reactions.
• 22. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I. Preparation of potassium dihydrogen phosphate I.
• 23. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I. Preparation of potassium dihydrogen phosphate I.
• 24. Electrolytic dissociation. Weak and strong electrolytes. Preparation of boric acid from borax I. Preparation of potassium dihydrogen phosphate I.
• 25. Acid-base equilibrium I. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 26. Acid-base equilibrium I. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 27. Acid-base equilibrium I. Buffers. Observation of hydrolysis of salts Demonstration of buffer capacity.
• 28. Acid-base equilibrium II. Acid-base theories. Hydrolysis of ions. Preparation of iron(II) ammonium sulfate.
• 29. Acid-base equilibrium II. Acid-base theories. Hydrolysis of ions. Preparation of iron(II) ammonium sulfate.
• 30. Acid-base equilibrium II. Acid-base theories. Hydrolysis of ions. Preparation of iron(II) ammonium sulfate.
• 31. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 32. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 33. Redox reactions I. Oxidation state. Important oxidizing and reducing agents. Observation of oxidation-reduction reactions.
• 34. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 35. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 36. Heterogenous equilibrium. Solubility calculations. Qualitative comparison of solubility products.
• 37. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 38. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 39. Redox reactions II. Electrodes, electrochemical cells, electrolysis. Preparation of copper(I) oxide.
• 40. Characterization of complexes. Stability constants. Preparation of potassium tris(oxalato) iron(III).
• 41. Characterization of complexes. Stability constants. Preparation of potassium tris(oxalato) iron(III).
• 42. Characterization of complexes. Stability constants. Preparation of potassium tris(oxalato) iron(III).

Seminars

Reading material

Obligatory literature

Ebbing D.D., Gammon S.D.: General Chemistry, 9th edition, Houghton Miffin Co., Boston, 2009

Literature developed by the Department

Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices. University of Pécs, 2014. Electronic educational material,
Huber I: Inorganic Pharmaceutical Chemistry I. University of Pécs, 2019. Electronic educational material

Notes

Recommended literature

en.wikobooks.org/wiki/General_Chemistry

Conditions for acceptance of the semester

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory. Maximum three absences can be accepted. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Making up for missed classes

There is no opportunity to make up missed classes (lectures and practices).

Exam topics/questions

N/A

Examiners

Instructor / tutor of practices and seminars

• Dr. Fatemeh KENARI
• Dr. Almási Attila
• Dr. Perjési Pál
• Fülöpné Dr. Kiss Edit