Chemical Basis of Pharmaceutical Technology Excipients and Incompatibilities

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

The physicochemical properties of the excipients used in pharmaceutical technology fundamentally determine the process of drug preparation. In compulsory subjects such as Pharmaceutical Chemistry and Pharmaceutical Technology, there is no opportunity to discuss these relationships in depth. Our goal in this course is to provide our students with additional information about the physicochemical properties and incompatibilities of excipients that may be helpful in either magistral preparation or industrial drug manufacturing processes.

Lectures

• 1. Introduction: excipients, their classification, general information - Dr. Kulcsár Győző Kornél
• 2. Chemistry of excipients of liquid pharmaceutical forms - Dr. Mészáros Petra
• 3. Chemistry of excipients of emulsions and suspensions - Dr. Tyukodi Levente
• 4. Chemical aspects of semi-solid pharmaceutical forms - Dr. Mészáros Petra
• 5. Pharmacopoeial methods of testing of excipients, requirements, demands, instrumental and classical chemistry tests - Dr. Kulcsár Győző Kornél
• 6. First mid-term test - Dr. Kulcsár Győző Kornél
• 7. Chemistry of excipients of solid pharmaceutical forms 1. - Dr. Kulcsár Győző Kornél
• 8. Chemistry of excipients of solid pharmaceutical forms 2. - Dr. Kulcsár Győző Kornél
• 9. Excipients of biological products - Fülöpné Dr. Kiss Edit
• 10. Chemical aspects of incompatibilities - Dr. Tyukodi Levente
• 11. Examples of common incompatibilities - Dr. Varga Réka
• 12. How to choose packaging, chemical aspects of incompatibilities of packaging - Dr. Varga Réka
• 13. Second mid-term test - Dr. Kulcsár Győző Kornél
• 14. Questions, summary - Dr. Kulcsár Győző Kornél

Practices

Seminars

Reading material

Obligatory literature

Lecture notes

Literature developed by the Department

Notes

Recommended literature

1. Handbook of Pharmaceutical Excipients. (Pharmaceutical Press, 2009).
2. Pharmaceutical excipients. Pharmazeutische Industrie (John Wiley & Sons, Inc, 2017). doi:10.5005/jp/books/12863_3
3. Council of Europe - EDQM. European Pharmacopoeia 10th Edition. Oak Bark vol. I (2020).

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Students must fulfil requirements determined by the Code of Studies and Examinations. A maximum of three absences per semester may be accepted. The subject ends with a mid-term grade.
Students have to write three assessments during the semester, and they have to reach higher than 60 % after average calculation. The third assessment if necessary (which is considered as the 1st and 2nd retake) is possible at the end of the semester.

Making up for missed classes

There is no way to make up for the absence. Students must fulfil requirements determined by the Code of Studies and Examinations

Exam topics/questions

Students will receive the topic lists in the Institute and/or on the website.

Examiners

Instructor / tutor of practices and seminars