Telefon: 36356, 35361
Supervisor: VERES, Balázs
Co-supervisor: Dr. ANTUS, Csenge
Sepsis is one of the leading causes of death in intensive care units affecting more than 18 million people worldwide. Although precise mechanisms by which sepsis leads to multiple organ dysfunction are unknown, growing evidence suggests that blocking the main inflammatory signaling pathways might be a strategy to control the pathophysiology of sepsis. Nuclear factor-κB (NF-κB) as one of the most important inflammatory transcription factors plays a crucial role in regulation of uncontrollable inflammatory processes leading to sepsis. A number of enzymes and adaptor proteins play important role in signaling pathway between the cell surface TLR4 receptor and the NF-κB transcription factor, localized in the nucleus, thereby our studies focusing on these molecules.