Introduction to Biochemistry

Data

Official data in SubjectManager for the following academic year: 2019-2020

Course director

Number of hours/semester

lectures: 28 hours

practices: 28 hours

seminars: 0 hours

total of: 56 hours

Subject data

  • Code of subject: OAA-BEB-T
  • 4 kredit
  • General Medicine
  • Basic modul
  • spring
Prerequisites:

-

Exam course:

yes

Course headcount limitations

min. 1

Topic

"Introduction to Biochemistry" includes the topics of organic and bioorganic chemistry along with basic biochemistry which are necessary for medical students. It deals with the structure, chemistry, and cellular degradation of essential biomolecules like proteins, carbohydrates and lipids. The purpose of practices is to study some analytical chemistry and the knowledge of materials. Curriculum of medical chemistry contains the basic knowledge that is necessary to understand biochemistry, pharmacology and clinical chemistry.

Lectures

  • 1. Introduction - Dr. Veres Balázs
  • 2. Carbonic acid derivatives - Dr. Gulyás Gergely
  • 3. Nucleosides, nucleotides, nucleic acids - Dr. Nagy Veronika
  • 4. Nucleotide coenzymes, bioenergetics - Dr. Berente Zoltán
  • 5. Amino acids, peptides - Dr. Berente Zoltán
  • 6. Proteins, primary structure, sequencing - Dr. Berente Zoltán
  • 7. Protein 3D structure and function - Dr. Berente Zoltán
  • 8. Hemoglobin, oxygen transport - Dr. Takátsy Anikó
  • 9. Basics of enzyme kinetics - Dr. Berente Zoltán
  • 10. Regulation and inhibition of enzymatic activity, isoenzymes - Dr. Takátsy Anikó
  • 11. Structure and reactivity of carbohydrates - Dr. Nagy Veronika
  • 12. Medically relevant mono-, di- and oligosaccharides - Dr. Nagy Veronika
  • 13. Biochemical processes - Dr. Veres Balázs
  • 14. Biological membranes - Dr. Takátsy Anikó
  • 15. Reactions of glycolysis - Dr. Nagy Veronika
  • 16. Regulation of glycolysis - Dr. Nagy Veronika
  • 17. Metabolic pathways linked to glycolysis - Dr. Nagy Veronika
  • 18. Composition of simple and complex lipids - Dr. Nagy Veronika
  • 19. Biologically relevant lipids (prostaglandins, terpenoids) - Dr. Nagy Veronika
  • 20. Biologically relevant lipids (steroids) - Dr. Lóránd Tamás
  • 21. Characterization of biological membranes - Dr. Takátsy Anikó
  • 22. Fatty acid oxidation - Dr. Takátsy Anikó
  • 23. Reactions of TCA cycle (PDC included) - Dr. Veres Balázs
  • 24. Regulation of TCA cycle - Dr. Jávor-Hocsák Enikő
  • 25. Respiratory chain and its inhibition - Dr. Takátsy Anikó
  • 26. ATP synthesis - Dr. Takátsy Anikó
  • 27. Mitochondrial transport processes, shuttles - Dr. Takátsy Anikó
  • 28. Supramolecular organization of functionally related enzymes - Dr. Berente Zoltán

Practices

  • 1. Basics of bioorganic chemistry
  • 2. Basics of bioorganic chemistry
  • 3. Isolation of caffeine
  • 4. Isolation of caffeine
  • 5. Stereochemistry
  • 6. Stereochemistry
  • 7. Proteins, gel filtration, dialysis
  • 8. Proteins, gel filtration, dialysis
  • 9. Enzymes I.
  • 10. Enzymes I.
  • 11. Enzymes II.
  • 12. Enzymes II.
  • 13. Warburg's optical test
  • 14. Warburg's optical test
  • 15. Properties of carbohydrates
  • 16. Properties of carbohydrates
  • 17. Properties of lipids
  • 18. Properties of lipids
  • 19. Metabolism I.
  • 20. Metabolism I.
  • 21. Metabolism II.
  • 22. Metabolism II.
  • 23. Mitochondrial oxidation
  • 24. Mitochondrial oxidation
  • 25. Metabolism III.
  • 26. Metabolism III.
  • 27. Metabolism IV.
  • 28. Metabolism IV.

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 5th ed., W.H. Freeman, 2008 http://bcs.whfreeman.com/lehninger5e
Berg, Tymoczko, Stryer: Biochemistry, 7th ed. http://bcs.whfreeman.com/berg7e
McMurray, Fay: Chemistry, latest edition
Darrell D. Ebbing (ed.): General Chemistry, latest edition
P. Gergely (ed.): Organic and Bioorganic Chemistry for Medical Students, Univ. Med. School of Debrecen
K. C. Timberlake: Chemistry - An Introduction to General, Organic and Biological Chemistry, latest edition

Literature developed by the Department

Notes

Veronika Nagy (ed.): Laboratory Experiments in Medical Chemistry, Internet edition, Univ. Med. School of Pécs, 2011

Recommended literature

Conditions for acceptance of the semester

Requirement for acceptance of "Introduction to biochemistry" (i.e. signature) is completing two Test Papers reaching minimum 30% as an average. During weeks 2-12 of the semester there are short tests at the beginning of each practice. Additional requirement for acceptance of "Introduction to biochemistry" is writing 8 out of these 10 tests, and at least 5 out of them should be correct and accepted by the lab instructor. It is obligatory to write lab-notes. Result of the short test is acknowledged only if the lab-note of the practice is accepted by the lab instructor.

Mid-term exams

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Making up for missed classes

None.

Exam topics/questions

-

Examiners

  • Dr. Agócs Attila
  • Dr. Berente Zoltán
  • Dr. Bóna Ágnes
  • Dr. Böddi Katalin
  • Dr. Gulyás Gergely
  • Dr. Jakus Péter Balázs
  • Dr. Lóránd Tamás
  • Dr. Prauda Ibolya Zsuzsanna
  • Dr. Radnai Balázs
  • Dr. Szabó Éva
  • Dr. Takátsy Anikó
  • Dr. Veres Balázs
  • Nagyné Dr. Kiss Gyöngyi
  • Szilágyi Tamás Gábor

Instructor / tutor of practices and seminars

  • Dr. Berente Zoltán
  • Dr. Bóna Ágnes
  • Dr. Böddi Katalin
  • Dr. Jakus Péter Balázs
  • Dr. Nagy Veronika
  • Nagyné Dr. Kiss Gyöngyi
  • Szilágyi Tamás Gábor