Department of Biochemistry and Medical Chemistry · Subjects · Medical Chemistry

Data

Official data in SubjectManager for the following academic year: 2019-2020

Course director

Dr. Zoltán BERENTE

associate professor,
Department of Biochemistry and Medical Chemistry
zoltan.berente@aok.pte.hu

Number of hours/semester

lectures: 42 hours

practices: 28 hours

seminars: 14 hours

total of: 84 hours

Subject data

Code of subject: OAA-ORK-T
6 kredit
General Medicine
Basic modul
autumn

Prerequisites:

OAR-OKA-T parallel

Exam course:

yes

Course headcount limitations

min. 1 – max. 300

Topic

Medical chemistry includes the topics of general chemistry which are necessary for medical students. It deals also with the chemistry of organic functional groups in a concise way. Majority of the curriculum deals with the bioorganic chemistry, which means the chemistry and descriptive biochemistry of biomolecules. The purpose of practices is to study some analytical chemistry and the knowledge of materials. Curriculum of medical chemistry contains the basic knowledge that is necessary to understand biochemistry, pharmacology and clinical chemistry.

Lectures

1. Introduction to Medical Chemistry, its relationship with medicine. - Dr. Ohmacht Róbert
2. The periodic table, the electronic structure of atoms. - Dr. Nagy Veronika
3. Chemical bonds. Ionic, covalent and metallic bond - Dr. Nagy Veronika
4. Chemical bonds. Basics of MO and VB theories. - Dr. Nagy Veronika
5. Secondary interactions. - Dr. Nagy Veronika
6. Chemistry, types and properties of the elements. - Dr. Berente Zoltán
7. Oxides, hydroxides, acids, bases and salts. - Dr. Berente Zoltán
8. States of matter, gas laws. - Dr. Takátsy Anikó
9. Water and aqueous solutions. Colligative properties of dilute solutions. Composition of biofluids - Dr. Takátsy Anikó
10. Role of electrolytes in living organisms - Dr. Berente Zoltán
11. Chemical equilibrium, mass action law - Dr. Lóránd Tamás
12. Heterogeneous equilibria. Solubility product constant. Gallstones and kidney stones - Dr. Lóránd Tamás
13. Acids and bases - Dr. Lóránd Tamás
14. Ion product constant of water, pH, pOH - Dr. Lóránd Tamás
15. Hydrolysis of salts. Buffer solutions. - Dr. Lóránd Tamás
16. Buffer systems in living organisms - Dr. Takátsy Anikó
17. Structure and formation of complexes. - Dr. Takátsy Anikó
18. Metal complexes in living organisms and in medical diagnosis - Dr. Takátsy Anikó
19. Colloid systems - Dr. Berente Zoltán
20. Colloid systems in living organisms - Dr. Dóczi Tamás
21. Chemical kinetics - Dr. Nagy Veronika
22. Thermodynamics: Energy changes in chemical reactions - Dr. Nagy Veronika
23. Thermodynamics: spontaneous and non-spontaneous reactions - Dr. Nagy Veronika
24. Photochemistry. Light induced reactions in living organisms - Dr. Nagy Veronika
25. Electrochemistry - Dr. Berente Zoltán
26. Electron transfer processes in living organisms - Dr. Berente Zoltán
27. Introduction to organic chemistry - Dr. Agócs Attila
28. Reaction types in organic chemistry - Dr. Agócs Attila
29. Saturated hydrocarbons: Alkanes. Paraffins in medicine - Dr. Lóránd Tamás
30. Unsaturated hydrocarbons: Alkenes and alkynes - Dr. Lóránd Tamás
31. Isomerism among alkanes, cycloalkanes and alkenes - Dr. Lóránd Tamás
32. Aromatic hydrocarbons. Organic halides - Dr. Gulyás Gergely
33. Optical isomerism. Relative and absolute configuration. - Dr. Agócs Attila
34. Alcohols - Dr. Lóránd Tamás
35. Phenols - Dr. Lóránd Tamás
36. Ethers - Dr. Lóránd Tamás
37. Organic thio compounds - Dr. Lóránd Tamás
38. Aldehydes and their derivatives - Dr. Agócs Attila
39. Ketones, quinones - Dr. Agócs Attila
40. Amines and their biologically relevant derivatives - Dr. Lóránd Tamás
41. Carboxylic acids - Dr. Lóránd Tamás
42. Carboxylic esters, phosphate esters and sulphate esters - Dr. Lóránd Tamás

Practices

1. Laboratory regulations. Accident and fire protection
2. Laboratory regulations. Accident and fire protection
3. Introductory discussion
4. Introductory discussion
5. Experiments with compounds of halogens, oxygen-group and nitrogen group elements
6. Experiments with compounds of halogens, oxygen-group and nitrogen group elements
7. Experiments with compounds of carbon-group, aluminium and s-block elements
8. Experiments with compounds of carbon-group, aluminium and s-block elements
9. Discussion
10. Discussion
11. Titration of Betacid solution
12. Titration of Betacid solution
13. Potentiometry. Buffer solutions.
14. Potentiometry. Buffer solutions.
15. Reactions of coordinative (complex) compounds.
16. Reactions of coordinative (complex) compounds.
17. Experiments on colloidal systems, chemical equilibria, and catalysis
18. Experiments on colloidal systems, chemical equilibria, and catalysis
19. Experiments in Electrochemistry
20. Experiments in Electrochemistry
21. Organic chemistry I. Reactions of functional groups I
22. Organic chemistry I. Reactions of functional groups I
23. Organic chemistry II. Reactions of functional groups II
24. Organic chemistry II. Reactions of functional groups II
25. Organic chemistry III. Reactions of functional groups III
26. Organic chemistry III. Reactions of functional groups III
27. Closing remarks, repetition
28. Closing remarks, repetition

Seminars

1. Basic concepts, stoichiometric calculations
2. Stoichiometric calculations
3. Geometry and polarity of molecules. Intermolecular interactions
4. Concentration of solutions
5. Structure of simple organic molecules
6. Naming organic molecules. Isomerism
7. Structure and properties of various types of organic compounds
8. Stereochemistry I. Chirality, enantiomers
9. Stereochemistry II: Diastereomers
10. Reactions in organic chemistry I: Types of reactions
11. Reactions in organic chemistry II: Alkenes and aromatic compounds
12. Reactions in organic chemistry III: Alcohols
13. Reactions in organic chemistry IV: Oxo compounds
14. Reactions in organic chemistry V: Carboxylic acids

Reading material

Obligatory literature

Textbooks:
McMurray, Fay: Chemistry, latest edition
P. Gergely (ed.): Organic and Bioorganic Chemistry for Medical Students, latest edition, Univ. Med. School of Debrecen

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

Recommended literature

Veronika Nagy (ed.): Laboratory Experiments in Medical Chemistry, Internet edition, Univ. Med. School of Pécs, 2011
K. C. Timberlake: Chemistry - An Introduction to General, Organic and Biological Chemistry, latest edition

Conditions for acceptance of the semester

Students are allowed to have a maximum of 3 absences from laboratory practices and a maximum of 3 absences from seminars during the whole semester.
During weeks 3-14 the allowed number of absences is 2 for laboratory practices and 2 for seminars.

Mid-term exams

Seven laboratory practices on weeks 3-14 must be successfully accomplished (i.e. a successful lab test must be submitted at the beginning of the practice and a workbook, which is filled to a satisfactory extent and quality, must be submitted after the practice) in order to achieve the right to register for the exam. Students can achieve 1 or 0 exam points in the lab tests.
Seminars on weeks 3-14 start with a skills assessment test. Three assessment tests must be successful from each expected calculation and formula writing skills, otherwise the student will not be allowed to take the semester exam.
Make-up opportunities for lab tests and skills assessments will be provided in accordance with the Code of Studies and Examinations, during the exam period.

Making up for missed classes

None.

Exam topics/questions