Data
Official data in SubjectManager for the following academic year: 2019-2020
Course director
-
Dr. Péter JAKUS
assistant professor,
Department of Biochemistry and Medical Chemistry -
Number of hours/semester
lectures: 42 hours
practices: 0 hours
seminars: 0 hours
total of: 42 hours
Subject data
- Code of subject: OSA-BKD-T
- 3 kredit
- Dentistry
- Basic modul
- autumn
OSA-ORF-T completed , OSA-BEF-T completed
Exam course:yes
Course headcount limitations
min. 1 – max. 200
Topic
The subject gives an overview of the molecular processes occurring in living organisms from two major aspects. On the one hand, following the subject -Introduction to Biochemistry&-, it describes the metabolism of the four major types of biomolecules (carbohydrates, lipids, amino ac ids/proteins and nucleotides /nucleic acids) along with the indirect enzymatic regulation of
these processes. On the other hand, built on the subject -Molecular Cell Biology&-, accounts for the molecular processes responsible for the transmission of information within the living organisms from molecular biological (DNA-RNA-protein-metabolite) as well as hormonal point of view. The subject lies down the foundations of the subjects Medical Biochemistry, Pharmacology and Clinical Chemistry.
Lectures
- 1. Introduction - Dr. Jakus Péter Balázs
- 2. The pentose phosphate pathway - Dr. Veres Balázs
- 3. Gluconeogenesis in animal cells - Dr. Jakus Péter Balázs
- 4. Glycogen synthesis and degradation - Dr. Bognár Zita
- 5. Regulation of glycogen synthesis and degradation - Dr. Bognár Zita
- 6. Regulation and disorders of carbohydrate metabolism - Dr. Tapodi Antal
- 7. Fatty acid synthesis (with elongation and desaturation) - Dr. Tapodi Antal
- 8. Synthesis of complex lipids - Dr. Gallyas Ferenc
- 9. Structure and biological activities of steroids - Dr. Gallyas Ferenc
- 10. Synthesis of cholesterol and ketone bodies - Dr. Gallyas Ferenc
- 11. Regulation and disorders of lipid metabolism - Dr. Gallyas Ferenc
- 12. Amino acid metabolism; the fate of the amino group - Dr. Debreceni Balázs
- 13. Urea cycle - Dr. Debreceni Balázs
- 14. Amino acid metabolism; the fate of the carbon skeleton - Dr. Debreceni Balázs
- 15. Synthesis of non-essential amino acids - Dr. Debreceni Balázs
- 16. Enzymopathies of amino acid metabolism - Dr. Debreceni Balázs
- 17. Synthesis of biologically active molecules from amino acids - Dr. Debreceni Balázs
- 18. Synthesis of purine and pyrimidine nucleotides - Dr. Jakus Péter Balázs
- 19. Degradation of purine and pyrimidine nucleotides - Dr. Jakus Péter Balázs
- 20. Genes and chromosomes - Dr. Jakus Péter Balázs
- 21. DNA replication - Dr. Jakus Péter Balázs
- 22. DNA repair - Dr. Jakus Péter Balázs
- 23. RNA metabolism 1 - Dr. Veres Balázs
- 24. RNA metabolism 2 - Dr. Veres Balázs
- 25. Short RNA molecules - Dr. Veres Balázs
- 26. Retroviruses - Dr. Veres Balázs
- 27. Protein synthesis 1. Participants and mechanism - Dr. Jakus Péter Balázs
- 28. Protein synthesis 2. Regulation, posttranslational modifications - Dr. Berente Zoltán
- 29. Protein folding, chaperones - Dr. Berente Zoltán
- 30. Protein targeting and vesicular transport of proteins - Dr. Berente Zoltán
- 31. Intracellular proteolysis - Dr. Jakus Péter Balázs
- 32. Regulation of gene expression 1 - Dr. Jakus Péter Balázs
- 33. Regulation of gene expression 2 - Dr. Sümegi Balázs
- 34. Mitochondrial protein synthesis, mitochondrial genome - Dr. Sümegi Balázs
- 35. Recombinant DNA technologies - Dr. Jakus Péter Balázs
- 36. Hormones 1 - Dr. Tapodi Antal
- 37. Hormones 2 - Dr. Tapodi Antal
- 38. Cell signalling and kinases I - Dr. Veres Balázs
- 39. Cell signalling and kinases II - Dr. Jakus Péter Balázs
- 40. Cell signalling, CO and NO as signals, transcription factors - Dr. Jakus Péter Balázs
- 41. Water soluble vitamins - Dr. Jakus Péter Balázs
- 42. Lipid soluble vitamins - Dr. Jakus Péter Balázs
Practices
Seminars
Reading material
Obligatory literature
Nelson, Cox: Lehninger Principles of Biochemistry, 6th edition, W.H. Freeman, 2013
Literature developed by the Department
Notes
Nagy V.: Experiments is Med. Chem. lab manual, 2017
Nagy V.: Introduction to biochemistry lab manual 2017
Recommended literature
Berg, Tymoczko, Stryer: Biochemistry, 7th edition, W.H. Freeman, 2012.
Devlin: Textbook of Biochemistry with Clinical Correlations 7th edition, Wiley, 2010.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
It is obligatory to visit the lectures.
Making up for missed classes
Non
Exam topics/questions
The exam based on the lectures and labs of the previous semesters and the lectures of the actual semester.
After entering into the website of the UNI: http://aok.pte.hu/en/egyseg/oktatasianyagok/20
Examiners
- Dr. Bognár Zita
- Dr. Jakus Péter Balázs
- Dr. Takátsy Anikó
- Dr. Tapodi Antal