Nuclear Magnetic Resonance in Drug Development

Data

Official data in SubjectManager for the following academic year: 2020-2021

Course director

Number of hours/semester

lectures: 0 hours

practices: 0 hours

seminars: 0 hours

total of: 0 hours

Subject data

  • Code of subject: OXF-MMG-r-T
  • 1 kredit
  • Pharmacy
  • Optional modul
  • spring
Prerequisites:

OHO-GE2-T parallel , OHA-M1E-T parallel

Course headcount limitations

min. 3 – max. 20

Topic

The course provides an insight into the process of drug development through examples that involve nuclear magnetic resonance as an analytical tool. The method is extensively applied at numerous different points of the process, due to its versatility.
The course will discuss, after a brief theoretical introduction, the study of structure determination and structure-activity relationship of drug candidate molecules. In the second phase the course will discuss some (mostly in vivo) applications used for the investigation of the efficacy of drug candidates in various animal models.

Lectures

Practices

Seminars

Reading material

Obligatory literature

None

Literature developed by the Department

See Neptun Meet Street

Notes

See Neptun Meet Street

Recommended literature

R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998
N. Beckman: In vivo MR Techniques in Drug Discovery and Development, Taylor and Francis, 2006
http://cis.rit.edu/htbooks/nmr
http://cis.rit.edu/htbooks/mri
http://www.imaios.com/en/e-Courses/e-MRI
http://www.magnetic-resonance.org/
http://eprints.drcmr.dk/37/1/MRI_English_a4.pdf

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Presentation of a home project is required.

Making up for missed classes

On the judgement of the course director.

Exam topics/questions

-

Examiners

Instructor / tutor of practices and seminars