Biochemistry 2

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

The subject serves as a foundation for the preclinical subjects Pathobiochemistry, Pharmacology, Pathophysiology, and the clinical subjects Internal Medicine, Clinical Chemistry and Neurology.
The 2nd semester of the 2-semester Biochemistry course - based on the material covered by the 1st semester - gives a deeper view into the fundamentals of structure-function relationships of small- and macromolecules, especially focusing on the structure, function and regulation of the molecules that are involved in the storage and transmission of genetic information, and dealing with basic molecular biology techniques. Furthermore, the regulation mechanisms of metabolic, hormonal and signal transduction pathways on the levels of the cell as well as of the organism are covered. The special biochemical characteristics of the different organs are also discussed.

Lectures

• 1. Introduction - Dr. Berente Zoltán
• 2. Interorgan division of metabolic labour - Dr. Berente Zoltán
• 3. Nutrition 1: Macro- and micronutrients, caloric balance - Dr. Berente Zoltán
• 4. Nutrition 2: digestion fluids and digestion enzymes - Dr. Berente Zoltán
• 5. Metabolic changes when switching from fed to fasting state - Dr. Gallyas Ferenc
• 6. Serum lipoproteins - Dr. Debreceni Balázs
• 7. Special functions of the liver - Dr. Veres Balázs
• 8. Molecular events following alcohol ingestion - Dr. Kovács Krisztina
• 9. Biochemical background of the pH regulation - Dr. Berente Zoltán
• 10. Trace elements, deficiencies - Dr. Berente Zoltán
• 11. Iron metabolism - Dr. Kovács Krisztina
• 12. Structural variants of hemoglobin - Dr. Kovács Krisztina
• 13. Proteins in blood, blood clotting - Dr. Kovács Krisztina
• 14. Biochemistry of blood vessels - Dr. Kovács Krisztina
• 15. Molecular mechanisms of water and electrolyte household - Dr. Berente Zoltán
• 16. Molecular mechanisms of blood pressure regulation - Dr. Sümegi Balázs
• 17. Molecular mechanisms of cardiac function - Dr. Sümegi Balázs
• 18. Biochemical background of diabetes - Dr. Sümegi Balázs
• 19. Molecular mechanisms of glucose uptake - Dr. Sümegi Balázs
• 20. Oxidative stress induced signalling pathways - Dr. Sümegi Balázs
• 21. Biochemistry of the inflammatory processes - Dr. Veres Balázs
• 22. Mechanisms of cell death - Dr. Sümegi Balázs
• 23. The cell cycle and its regulation - Dr. Debreceni Balázs
• 24. Oncogenes and oncogenesis - Dr. Debreceni Balázs
• 25. Tumor suppressors and cancer - Dr. Debreceni Balázs
• 26. Structure of the extracellular matrix - Dr. Tapodi Antal
• 27. Matrix metalloproteinases - Dr. Gallyas Ferenc
• 28. Biochemistry of the senses - Dr. Tapodi Antal
• 29. Nervous system I - Dr. Tapodi Antal
• 30. Nervous system II - Dr. Gallyas Ferenc
• 31. Nervous system III - Dr. Gallyas Ferenc
• 32. Biochemical features of the plasma membrane - Dr. Berente Zoltán
• 33. Biochemistry of the cytoskeletal function - Dr. Gallyas Ferenc
• 34. Molecular features of ER and Golgi - Dr. Gallyas Ferenc
• 35. Biochemical functions of lysosomes and peroxisomes - Dr. Tapodi Antal
• 36. Molecular mechanisms of the mitochondrial function - Dr. Sümegi Balázs
• 37. Proteins and biochemistry of the immune system - Dr. Kovács Krisztina
• 38. Molecular mechanisms of allergic reactions - Dr. Kovács Krisztina
• 39. Biochemistry of senescence - Dr. Gallyas Ferenc
• 40. Cellular regeneration - Marquettené Dr. Bock Ildikó
• 41. Progenitor cells - Marquettené Dr. Bock Ildikó
• 42. Therapeutics of the future - Marquettené Dr. Bock Ildikó

Practices

• 1. Distribution of enzymes among tissues
• 2. Distribution of enzymes among tissues
• 3. Molecular biological methods
• 4. Molecular biological methods
• 5. Analysis of body fluids
• 6. Analysis of body fluids
• 7. Hormonal Regulation of Metabolism
• 8. Hormonal Regulation of Metabolism
• 9. Determination of blood glucose
• 10. Determination of blood glucose
• 11. Apoptosis and Necrosis
• 12. Apoptosis and Necrosis
• 13. Determination of blood cholesterol
• 14. Determination of blood cholesterol
• 15. Stress Responses in Metabolism
• 16. Stress Responses in Metabolism
• 17. Determination of uric acid and bilirubin from blood
• 18. Determination of uric acid and bilirubin from blood
• 19. Acquired disorders of metabolism
• 20. Acquired disorders of metabolism
• 21. Student presentations
• 22. Student presentations
• 23. Student presentations
• 24. Student presentations
• 25. Study of cholinesterase
• 26. Study of cholinesterase
• 27. Consultation
• 28. Consultation

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 6th edition, W.H. Freeman, 2013.

Literature developed by the Department

see Neptun Meet Street

Notes

see Neptun Meet Street

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 7th edition, W.H. Freeman, 2012.
Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.
Lieberman, Marks: Marks' Basic Medical Biochemistry - A Clinical Approach, 4th edition, Lippincott, 2013

Conditions for acceptance of the semester

No more than three absences from the laboratory practices

Mid-term exams

- Submission of at least 10 out of 12 short tests held at the first 10 minutes of the practices
- Achieving satisfactory level in at least seven of the 12 short tests
Make-up is possible according to the Code of Studies and Examinations

Making up for missed classes

Permission should be asked from the course director to do the practice with an other group. Permission will be given maximum 2 times.

Exam topics/questions

The list of exam topics will be uploaded to Neptun Meet Street.
The exams, including the retaken exams are written exams of 36 open questions. Failure to answer more than three of the first 10 questions will automatically result in "failed" grade.
Further exam points can be achieved by oral presentations during the semester.

Examiners

• Dr. Berente Zoltán
• Dr. Gallyas Ferenc
• Dr. Sümegi Balázs

Instructor / tutor of practices and seminars

• Dr. Berente Zoltán
• Dr. Debreceni Balázs
• Dr. Farkas Viktória
• Dr. Jakus Péter Balázs
• Dr. Jávor-Hocsák Enikő
• Dr. Lengyel Anna
• Dr. Takátsy Anikó
• Dr. Tapodi Antal
• Dr. Veres Balázs
• Marquettené Dr. Bock Ildikó
• Nagyné Dr. Kiss Gyöngyi