Biochemistry 1 (42+14+14)

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 42 hours

practices: 28 hours

seminars: 0 hours

total of: 70 hours

Subject data

  • Code of subject: OSA-BK1-T
  • 5 kredit
  • Dentistry
  • Basic modul
  • autumn
Prerequisites:

OSA-BI2-T completed , OSA-MB2-T completed , OSA-OK2-T completed

Exam course:

yes

Course headcount limitations

min. 5 – max. 12

Topic

The subject gives an overview of the molecular processes occurring in living organisms from two major aspects.
On the one hand, following the subject Introduction to Biochemistry, describes the metabolism of the four major types of biomolecules (carbohydrates, lipids, amino acids/proteins and nucleotides/nucleic acids) along with the indirect enzymatic regulation of these processes.
On the other hand, built on the subjects Introduction to Biochemistry and Molecular Cell Biology, accounts for the molecular processes responsible for the transmission of information within the living organisms from molecular biological (DNA-RNA-protein-metabolite) as well as hormonal point of view.
The subject lies down the foundations of the subjects Medical Biochemistry, Pharmacology and Clinical Chemistry.

Lectures

  • 1. Introduction - Dr. Veres Balázs
  • 2. Biochemical processes (overview) - Dr. Veres Balázs
  • 3. Reactions of glycolysis - Dr. Agócs Attila
  • 4. Regulation of glycolysis - Dr. Agócs Attila
  • 5. Metabolic pathways linked to glycolysis - Dr. Kovács Krisztina
  • 6. Pentose phosphate pathway - Dr. Kovács Krisztina
  • 7. Reactions of TCA cycle (PDC included) - Dr. Jávor-Hocsák Enikő
  • 8. Regulation of TCA cycle - Dr. Takátsy Anikó
  • 9. Fatty acid oxidation - Dr. Kovács Krisztina
  • 10. Ketonbodies - Dr. Kovács Krisztina
  • 11. Respiratory chain and its inhibition - Dr. Takátsy Anikó
  • 12. ATP synthesis - Dr. Takátsy Anikó
  • 13. Mitochondrial transport processes, shuttles - Dr. Takátsy Anikó
  • 14. Gluconeogenesis - Dr. Takátsy Anikó
  • 15. Glycogen synthesis and degradation - Dr. Veres Balázs
  • 16. Regulation of glycogen metabolism - Dr. Veres Balázs
  • 17. Regulation of carbohydrate metabolism - Dr. Radnai Balázs
  • 18. Fatty acid synthesis - Dr. Radnai Balázs
  • 19. Synthesis of complex lipids - Dr. Radnai Balázs
  • 20. Cholesterol and lipoproteins - Dr. Radnai Balázs
  • 21. Regulation of lipid metabolism - Dr. Radnai Balázs
  • 22. Amino acid metabolism: the fate of amino group - Nagyné Dr. Kiss Gyöngyi
  • 23. Urea cycle - Dr. Fekete Katalin
  • 24. Amino acid metabolism: the fate of carbon skeleton - Dr. Veres Balázs
  • 25. Synthesis of non-essential amino acids - Dr. Veres Balázs
  • 26. Enzymopathies in amino acid metabolism - Dr. Veres Balázs
  • 27. Biologically active compounds - Dr. Veres Balázs
  • 28. Synthesis of purin and pyrimidin nucleotides - Dr. Bognár Zita
  • 29. Degradation of purin and pyrimidin nucleotides - Dr. Bognár Zita
  • 30. Protein -DNA interactions - Dr. Tapodi Antal
  • 31. Regulation of gene expression - Dr. Tapodi Antal
  • 32. Small RNAs - Dr. Tapodi Antal
  • 33. Retroviruses - Dr. Tapodi Antal
  • 34. Folding, PTM - Dr. Berente Zoltán
  • 35. Protein targeting, degradation - Dr. Berente Zoltán
  • 36. Hormones 1 - Dr. Tapodi Antal
  • 37. Hormones 2 - Dr. Tapodi Antal
  • 38. Signal transduction I. - Dr. Gallyas Ferenc
  • 39. Signal transduction II. - Dr. Gallyas Ferenc
  • 40. Signal transduction III. - Dr. Gallyas Ferenc
  • 41. Water soluble vitamins - Dr. Antus Csenge Petra
  • 42. Fat soluble vitamins - Dr. Jávor-Hocsák Enikő

Practices

  • 1. Introductory lab
  • 2. Introductory lab
  • 3. Inorganic phosphate requirement of glycolysis
  • 4. Inorganic phosphate requirement of glycolysis
  • 5. Concerted regulation of carbohydrate metabolism I.
  • 6. Concerted regulation of carbohydrate metabolism I.
  • 7. Concerted regulation of lipid metabolism I.
  • 8. Concerted regulation of lipid metabolism I.
  • 9. OXPHOS
  • 10. OXPHOS
  • 11. Concerted regulation of carbohydrate metabolism II.
  • 12. Concerted regulation of carbohydrate metabolism II.
  • 13. Concerted regulation of lipid metabolism II.
  • 14. Concerted regulation of lipid metabolism II.
  • 15. Escape room
  • 16. Escape room
  • 17. Study of chaperone function
  • 18. Study of chaperone function
  • 19. N-containing mol. Metabolism
  • 20. N-containing mol. Metabolism
  • 21. Inborn Errors of Metabolism
  • 22. Inborn Errors of Metabolism
  • 23. Student presentations I.
  • 24. Student presentations I.
  • 25. Student presentations II.
  • 26. Student presentations II.
  • 27. Consultation, student presentations
  • 28. Consultation, student presentations

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 6th edition, W.H. Freeman, 2013.

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 7th edition, W.H. Freeman, 2012.
Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.

Conditions for acceptance of the semester

Requirements of the acceptance of Biochemistry course are the following:
- No more than three absences from the laboratory practices
- Submission of at least 10 out of 12 short tests held in the first 10 minutes of the practices
- Achieving satisfactory level in at least seven of the 12 short tests

Mid-term exams

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Making up for missed classes

There is no possibility to make up the practices.

Exam topics/questions

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Examiners

  • Andreidesz Kitti
  • Bagóné Dr. Vántus Viola
  • Dr. Agócs Attila
  • Dr. Antus Csenge Petra
  • Dr. Berente Zoltán
  • Dr. Bognár Zita
  • Dr. Fekete Katalin
  • Dr. Jakus Péter Balázs
  • Dr. Jávor-Hocsák Enikő
  • Dr. Kálmán Nikoletta
  • Dr. Kovács Krisztina
  • Dr. Radnai Balázs
  • Dr. Szabó Aliz
  • Dr. Takátsy Anikó
  • Dr. Tapodi Antal
  • Dr. Veres Balázs
  • Kovács Dominika
  • Kőszegi Balázs
  • Nagyné Dr. Kiss Gyöngyi

Instructor / tutor of practices and seminars

  • Andreidesz Kitti
  • Bagóné Dr. Vántus Viola
  • Dr. Agócs Attila
  • Dr. Antus Csenge Petra
  • Dr. Berente Zoltán
  • Dr. Bognár Zita
  • Dr. Fekete Katalin
  • Dr. Jávor-Hocsák Enikő
  • Dr. Kálmán Nikoletta
  • Dr. Kovács Krisztina
  • Dr. Radnai Balázs
  • Dr. Takátsy Anikó
  • Dr. Tapodi Antal
  • Dr. Veres Balázs
  • Kovács Dominika
  • Kőszegi Balázs
  • Nagyné Dr. Kiss Gyöngyi