Biochemistry 2

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

Medical Biochemistry is a single semester subject concluding in an oral colloquium that is preceded by a written MRT of 10 explanatory questions, of which at least 70% should be scored. Although not a prerequisite, the metabolic processes covered during Biochemistry course form the basis of Medical Biochemistry. Prerequisites of signing up for Medical Biochemistry is completion of Medical Chemistry, Introduction to Biochemistry, and Molecular Cell Biology 2. The aim of the course is to teach the students how the metabolic processes and the molecular events of biological information transmission form the basis of human diseases. Thus, students are supposed to gain a molecular level insight into the processes by which living organisms sustain their life functions or react to various stimuli, physiological or pathological conditions. Medical Biochemistry, based on previously acquired knowledge, presents the molecular level alterations appearing under various physiological and pathological circumstances with special respect to organ and organelle specific issues. Moreover, the biochemical background of related disorders and diseases will be also mentioned.
Completion of the course is direct prerequisite of higher year subjects Pharmacology and Clinical Biochemistry. In addition, the material covers the introduction to certain chapters of Internal Medicine and Paediatrics also.

Lectures

• 1. Introductory lecture - Dr. Kovács Krisztina
• 2. Contribution of different tissues to the metabolic processes - Dr. Tapodi Antal
• 3. Biochemistry of well fed and fasting states, regulation of bodyweight - Dr. Gallyas Ferenc
• 4. Disorders of amino acid metabolism - Dr. Veres Balázs
• 5. Nutrition: macro- and micronutrients - Dr. Berente Zoltán
• 6. Trace elements and their deficiencies - Dr. Berente Zoltán
• 7. Special functions of the liver - Dr. Veres Balázs
• 8. Detoxification reactions of the liver - Dr. Veres Balázs
• 9. Biochemistry of kidney function - Dr. Takátsy Anikó
• 10. Biochemistry of pancreas function - Dr. Takátsy Anikó
• 11. Metabolic consequences of alcohol consumption - Dr. Kovács Krisztina
• 12. Disorders of the gastrointestinal tract - Dr. Kovács Krisztina
• 13. Hemoglobinopathies, hyperbilirubinemia - Dr. Kovács Krisztina
• 14. Iron metabolism in humans - Dr. Kovács Krisztina
• 15. Anemias, iron overload - Dr. Kovács Krisztina
• 16. Biochemistry of diabetes - Nagyné Dr. Kiss Gyöngyi
• 17. Molecular mechanisms of glucose uptake - Nagyné Dr. Kiss Gyöngyi
• 18. Oxidative stress induced signaling - Dr. Veres Balázs
• 19. Biochemistry of inflammation - Dr. Veres Balázs
• 20. Viruses - Dr. Veres Balázs
• 21. Biochemistry of blood vessels - Dr. Kovács Krisztina
• 22. Bone and joint disorders - Dr. Kovács Krisztina
• 23. Molecular mechanisms of blood pressure regulation - Dr. Tapodi Antal
• 24. Molecular mechanisms of heart function - Marquettené Dr. Bock Ildikó
• 25. Biochemistry of sensing - Dr. Bognár Zita
• 26. Nervous system I. - Dr. Gallyas Ferenc
• 27. Nervous system II. - Dr. Gallyas Ferenc
• 28. Nervous system III: Prion diseases, folding - Dr. Gallyas Ferenc
• 29. Biochemical functions of the cytoskeleton - Dr. Gallyas Ferenc
• 30. Functions of ER - Dr. Gallyas Ferenc
• 31. Matrix metalloproteinases - Dr. Gallyas Ferenc
• 32. Structure of the extracellular matrix - Marquettené Dr. Bock Ildikó
• 33. Cell cycle regulation, therapeutic potentials - Dr. Veres Balázs
• 34. Biochemistry of tumors - Dr. Bognár Zita
• 35. Therapeutic potential of DNA repair mechanisms - Dr. Kovács Krisztina
• 36. Biochemical functions of Golgi, lysosomes and peroxysomes - Dr. Tapodi Antal
• 37. Molecular mechanisms of mitochondrial function - Dr. Gallyas Ferenc
• 38. Biochemistry of aging - Marquettené Dr. Bock Ildikó
• 39. Cell death processes - Dr. Veres Balázs
• 40. Molecular based personalized medicine - Dr. Veres Balázs
• 41. Drug research and development - Dr. Gallyas Ferenc
• 42. Future perspecives in therapies - Marquettené Dr. Bock Ildikó

Practices

• 1. Carbohydrate metabolism
• 2. Carbohydrate metabolism
• 3. Determination of blood glucose
• 4. Determination of blood glucose
• 5. Biochemistry of the kidneys
• 6. Biochemistry of the kidneys
• 7. Analysis of body fluids
• 8. Analysis of body fluids
• 9. Reactive oxygen and nitrogen species in humans, antioxidant defense mechanisms
• 10. Reactive oxygen and nitrogen species in humans, antioxidant defense mechanisms
• 11. Determination of blood cholesterol
• 12. Determination of blood cholesterol
• 13. Disorders of acid-base balance
• 14. Disorders of acid-base balance
• 15. Determination of uric acid
• 16. Determination of uric acid
• 17. Student presentations
• 18. Student presentations
• 19. Vitamins
• 20. Vitamins
• 21. Non enzymatic glycation reactions, insulin resistance, metabolic syndrome
• 22. Non enzymatic glycation reactions, insulin resistance, metabolic syndrome
• 23. Heart muscle and neuronal cell death processes, ischemia-reperfusion, excitotocicity
• 24. Heart muscle and neuronal cell death processes, ischemia-reperfusion, excitotocicity
• 25. Strange and instructive
• 26. Strange and instructive
• 27. Consultation
• 28. Consultation

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 7th edition, W.H. Freeman, 2017.

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 8th edition, W.H. Freeman, 2015.
Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.
Lieberman, Marks: Marks' Basic Medical Biochemistry - A Clinical Approach, 4th edition, Lippincott, 2013

Conditions for acceptance of the semester

No more than three absences from the laboratory practices
No more than two absences from the laboratory practices during weeks 3-14.
Holding of an oral presentation about a given disorder provided in the presentation topic list.

Mid-term exams

Holding of an oral presentation about a given disorder provided in the presentation topic list.

Making up for missed classes

None.

Exam topics/questions

Exam requirements can be found:
http://aok.pte.hu/en/egyseg/oktatasianyagok/20

The semester ends with an exam. Successful accomplishment of the Biochemistry final exam is not a requirement of the Medical Biochemistry exam. Students have to achieve 70% on a written exam of minimum questions (MRE) prior to be allowed to the Medical Biochemistry oral exam. Those students who have already successfully accomplished the Biochemistry final exam are exempted from MRE questions 11-20 in the written test that is covered by the 99-244 equations of the MRT list.

Examiners

• Andreidesz Kitti
• Bagóné Dr. Vántus Viola
• Dr. Agócs Attila
• Dr. Berente Zoltán
• Dr. Bognár Zita
• Dr. Debreceni Balázs
• Dr. Fekete Katalin
• Dr. Gallyas Ferenc
• Dr. Jávor-Hocsák Enikő
• Dr. Kovács Krisztina
• Dr. Nagy Veronika
• Dr. Radnai Balázs
• Dr. Szabó Aliz
• Dr. Takátsy Anikó
• Dr. Tapodi Antal
• Dr. Veres Balázs
• Kovács Dominika
• Kőszegi Balázs
• Nagyné Dr. Kiss Gyöngyi

Instructor / tutor of practices and seminars

• Bagóné Dr. Vántus Viola
• Dr. Antus Csenge Petra
• Dr. Fekete Katalin
• Dr. Jakus Péter Balázs
• Dr. Jávor-Hocsák Enikő
• Dr. Kovács Krisztina
• Dr. Takátsy Anikó
• Dr. Tapodi Antal
• Dr. Veres Balázs
• Kőszegi Balázs
• Nagyné Dr. Kiss Gyöngyi