Medical Chemistry 1

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 42 hours

practices: 28 hours

seminars: 14 hours

total of: 84 hours

Subject data

  • Code of subject: OAA-OR1-T
  • 6 kredit
  • General Medicine
  • Basic modul
  • autumn
Prerequisites:

-

Exam course:

yes

Course headcount limitations

min. 1 – max. 300

Topic

Medical chemistry includes the topics of general chemistry which are necessary for medical students. It deals also with the chemistry of organic functional groups in a concise way. Majority of the curriculum deals with the bioorganic chemistry, which means the chemistry and descriptive biochemistry of biomolecules. The purpose of practices is to study some analytical chemistry and the knowledge of materials. Curriculum of medical chemistry contains the basic knowledge that is necessary to understand biochemistry, pharmacology and clinical chemistry. Medical Chemistry is a single semester subject concluding in an oral colloquium that is preceded by a written MRT of 10 explanatory questions, of which at least 70% should be scored.

Lectures

  • 1. Introduction to Medical Chemistry - Dr. Gallyas Ferenc
  • 2. Structure of matter (atoms, ions, molecules, radicals) - Dr. Nagy Veronika
  • 3. Intrduction to inorganic chemistry. Oxides, oxoacids, hydroxides, salts - Dr. Nagy Veronika
  • 4. Molecular geometry, polarity, molecular interactions - Dr. Nagy Veronika
  • 5. Introduction to organic chemistry. Nomenclatute, functional groups, Reaction types - Dr. Nagy Veronika
  • 6. States of matter, gas laws. - Dr. Takátsy Anikó
  • 7. Water and aqueous solutions. Concentration units. Colligative properties of dilute solutions. - Dr. Takátsy Anikó
  • 8. Osmosis, composition of biofluids - Dr. Berente Zoltán
  • 9. Equilibrium, the law of mass action, Le Chatelier principle - Dr. Takátsy Anikó
  • 10. Role of electrolytes in living organisms, solubilty - Dr. Takátsy Anikó
  • 11. Acids and bases, acid-base theories, acid-base reactions - Dr. Takátsy Anikó
  • 12. Ion product constant of water, pH, pOH, hydrolysis of salts, pH-dependence of protonation - Dr. Takátsy Anikó
  • 13. Buffer solutions - Dr. Takátsy Anikó
  • 14. Buffer systems in living organisms - Dr. Berente Zoltán
  • 15. Structure and formation of metal complexes. - Dr. Takátsy Anikó
  • 16. Metal complexes in living organisms and in medical diagnosis - Dr. Berente Zoltán
  • 17. Thermochemistry - Dr. Takátsy Anikó
  • 18. Thermodynamics and the direction of chemical reactions - Dr. Nagy Veronika
  • 19. Thermodynamics applied to living systems - Dr. Nagy Veronika
  • 20. Reactionkinetics - Dr. Nagy Veronika
  • 21. Steady-stateness, a characteristic of living systems - Dr. Nagy Veronika
  • 22. Kinetic characteristics of cascade- and cyclic reactions - Dr. Nagy Veronika
  • 23. Electrochemistry - Dr. Berente Zoltán
  • 24. Electron transfer processes in living organisms - Dr. Berente Zoltán
  • 25. Electrochemistry in the medical practice - Dr. Berente Zoltán
  • 26. Basics of analytical chemistry for medical students - Dr. Takátsy Anikó
  • 27. Basics of separation thechniques for medical students - Dr. Takátsy Anikó
  • 28. Analitical instruments in medical diagnostics - Dr. Berente Zoltán
  • 29. Introduction to organic chemistry - Dr. Nagy Veronika
  • 30. Reaction types in organic chemistry - Dr. Nagy Veronika
  • 31. Saturated hydrocarbons: Alkanes. Paraffins in medicine - Dr. Nagy Veronika
  • 32. Unsaturated hydrocarbons: Alkenes and alkynes - Dr. Nagy Veronika
  • 33. Isomerism among alkanes, cycloalkanes and alkenes - Dr. Nagy Veronika
  • 34. Aromatic hydrocarbons. Organic halides - Dr. Nagy Veronika
  • 35. Optical isomerism. Relative and absolute configuration. - Dr. Nagy Veronika
  • 36. Aldehydes and their derivatives - Dr. Böddi Katalin
  • 37. Ketones, quinones - Dr. Böddi Katalin
  • 38. Amines and their biologically relevant derivatives - Dr. Böddi Katalin
  • 39. Organic sulphur compounds, thioesthers - Dr. Nagy Veronika
  • 40. Amines and their biologically relevant derivatives - Dr. Nagy Veronika
  • 41. Colloid systems - Dr. Berente Zoltán
  • 42. Colloid systems in living organisms - Dr. Berente Zoltán

Practices

  • 1. Laboratory regulations. Accident and fire protection
  • 2. Laboratory regulations. Accident and fire protection
  • 3. Introductory discussion
  • 4. Introductory discussion
  • 5. Experiments with compounds of halogens, oxygen-group and nitrogen group elements
  • 6. Experiments with compounds of halogens, oxygen-group and nitrogen group elements
  • 7. Experiments with compounds of carbon-group, aluminium and s-block elements
  • 8. Experiments with compounds of carbon-group, aluminium and s-block elements
  • 9. Discussion
  • 10. Discussion
  • 11. Titration of Betacid solution
  • 12. Titration of Betacid solution
  • 13. Potentiometry. Buffer solutions.
  • 14. Potentiometry. Buffer solutions.
  • 15. Reactions of coordinative (complex) compounds.
  • 16. Reactions of coordinative (complex) compounds.
  • 17. Experiments on colloidal systems, chemical equilibria, and catalysis
  • 18. Experiments on colloidal systems, chemical equilibria, and catalysis
  • 19. Experiments in Electrochemistry
  • 20. Experiments in Electrochemistry
  • 21. Organic chemistry I. Reactions of functional groups I
  • 22. Organic chemistry I. Reactions of functional groups I
  • 23. Organic chemistry II. Reactions of functional groups II
  • 24. Organic chemistry II. Reactions of functional groups II
  • 25. Organic chemistry III. Reactions of functional groups III
  • 26. Organic chemistry III. Reactions of functional groups III
  • 27. Closing remarks, repetition
  • 28. Closing remarks, repetition

Seminars

  • 1. Basic concepts, stoichiometric calculations
  • 2. Stoichiometric calculations
  • 3. Geometry and polarity of molecules. Intermolecular interactions
  • 4. Concentration of solutions
  • 5. Structure of simple organic molecules
  • 6. Naming organic molecules. Isomerism
  • 7. Structure and properties of various types of organic compounds
  • 8. Stereochemistry I. Chirality, enantiomers
  • 9. Stereochemistry II: Diastereomers
  • 10. Reactions in organic chemistry I: Types of reactions
  • 11. Reactions in organic chemistry II: Alkenes and aromatic compounds
  • 12. Reactions in organic chemistry III: Alcohols
  • 13. Reactions in organic chemistry IV: Oxo compounds
  • 14. Reactions in organic chemistry V: Carboxylic acids

Reading material

Obligatory literature

Textbooks:
McMurray, Fay: Chemistry, latest edition
P. Gergely (ed.): Organic and Bioorganic Chemistry for Medical Students, latest edition, Univ. Med. School of Debrecen

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

-

Recommended literature

Veronika Nagy (ed.): Laboratory Experiments in Medical Chemistry, Internet edition, Univ. Med. School of Pécs, 2011
K. C. Timberlake: Chemistry - An Introduction to General, Organic and Biological Chemistry, latest edition

Conditions for acceptance of the semester

Students are allowed to have a maximum of 3 absences from laboratory practices and a maximum of 3 absences from seminars during the whole semester.
During weeks 3-14 the allowed number of absences is 2 for laboratory practices and 2 for seminars.

Mid-term exams

Seven laboratory practices on weeks 3-14 must be successfully accomplished (i.e. a successful lab test must be submitted at the beginning of the practice and a workbook, which is filled to a satisfactory extent and quality, must be submitted after the practice) in order to achieve the right to register for the exam. Students can achieve 1 or 0 exam points in the lab tests.
Seminars on weeks 3-14 start with a skills assessment test. Three assessment tests must be successful from each expected calculation and formula writing skills, otherwise the student will not be allowed to take the semester exam.
Make-up opportunities for lab tests and skills assessments will be provided in accordance with the Code of Studies and Examinations, during the exam period.

Making up for missed classes

None.

Exam topics/questions

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Examiners

  • Dr. Agócs Attila
  • Dr. Berente Zoltán
  • Dr. Gallyas Ferenc
  • Dr. Lóránd Tamás
  • Dr. Nagy Veronika
  • Dr. Takátsy Anikó

Instructor / tutor of practices and seminars

  • Dr. Agócs Attila
  • Dr. Bóna Ágnes
  • Dr. Böddi Katalin
  • Dr. Gulyás Gergely
  • Dr. Nagy Veronika
  • Dr. Takátsy Anikó
  • Nagyné Dr. Kiss Gyöngyi
  • Szilágyi Tamás Gábor