Microbiology 1

Data

Official data in SubjectManager for the following academic year: 2019-2020

Topic

During introduction the subject and history of medical microbiology and its place in medicine is discussed. The morphology, physiology and genetics of microbes, as well as the methods of disinfection and the theoretical aspects of antimicrobial therapy are the subjects of lectures on general microbiology. The host-parasite interactions involved in the pathogenesis of various infections, as well as the mechanisms of host defense, the possibilities of immunoprophylaxis, the pathways of allergies, tolerance, autoimmunity, the basics of neuroimmunology and the immunology of pregnancy will be described. The first semester also includes the course on systematic virology dealing with infections of viral and prion etiology in details.
The objective the first semester is to provide solid knowledge and view to students preparing them to understand the the subsequent systematic bacteriology, mycology, parasitology and clinical microbiology courses as well as clinical subjects relating to infections.

Lectures

• 1. Introduction i.: The subject and history of microbiology, taxonomy - Dr. Reuter Gábor Kamilló
• 2. Introduction II.:Earth and human microbiome - Dr. Reuter Gábor Kamilló
• 3. Essential bacterial cell components, - Dr. Emődy Levente
• 4. Accessorial bacterial cell components - Dr. Emődy Levente
• 5. The physiology of bacteria. Nutrition types and growth of bacteria - Dr. Kocsis Béla
• 6. Microbial genetics II - Dr. Tigyi Zoltán
• 7. Microbial genetics II - Dr. Tigyi Zoltán
• 8. Pathogenicity and virulence - Dr. Emődy Levente
• 9. Endotoxin - Dr. Kocsis Béla
• 10. Exotoxin - Dr. Emődy Levente
• 11. Sterilization - Dr. Bátai Istvánné (Dr. Kerényi Monika)
• 12. Disinfection - Dr. Bátai Istvánné (Dr. Kerényi Monika)
• 13. Anti-microbial drugs general introduction - Dr. Kocsis Béla
• 14. Chemotherapy: sulphonamides, quinolons, nitrofurans - Dr. Kocsis Béla
• 15. Inhibitors of cell wall biosynthesis; penicillins, cephalosporins, glycopeptides, carbapenems - Dr. Kocsis Béla
• 16. Inhibitors of protein synthesis; aminoglycosides, chloramphenicol, tetracyclines - Dr. Kocsis Béla
• 17. Macrolides, lincomycin, clindamycin, polypeptides, polymyxin, methronidaz - Dr. Kocsis Béla
• 18. Molecular mechanisms of antibiotic resistance - Dr. Emődy Levente
• 19. Characteristics of viruses (basic concepts, chemical composition, structure, classification); viral replication - Dr. Reuter Gábor Kamilló
• 20. Pathogenesis of viral infections (transmission modes and types of infection, acute and chronic viral infections) - Dr. Reuter Gábor Kamilló
• 21. Adenoviruses (serotypes, diseases); parvoviruses (parvovirus B19, bocavirus, bufavirus, parvovirus 4); anelloviruses - Dr. Reuter Gábor Kamilló
• 22. Herpesviruses I (HHV1, HHV2; HHV6, HHV7, HHV8) - Dr. Szereday László
• 23. Herpesviruses II (VZV/HHV3, EBV/HHV4, CMV/HHV5) - Dr. Szereday László
• 24. Papillomaviruses (HPV); polyomaviruses (JC, BK,MC, WU, and KI); poxviruses; slow virus infections (SSPE, PML); prion and prion diseases (Kuru, CJD, vCJD, GSS, FFI, MSA) - Dr. Reuter Gábor Kamilló
• 25. Hepatitis viruses (HAV, HBV, HCV, HDV, HEV, HGV) - Dr. Reuter Gábor Kamilló
• 26. Picornaviruses (enteroviruses, cardiovirus, cosavirus, kobuvirus, parechovirus, salivirus) - Dr. Reuter Gábor Kamilló
• 27. Orthomyxoviruses (Influenza A, B,C, and D viruses) - Dr. Szereday László
• 28. Paramyxoviruses: parainfluenza, mumps, morbilli, respiratory syntitial virus (RSV), human metapneumovirus (hMPV), Nipah and Hendra viruses - Dr. Reuter Gábor Kamilló
• 29. Coronaviruses (SARS, MERS and diseases); rubella virus (congenital rubella syndrome) - Dr. Reuter Gábor Kamilló
• 30. Viral gastroenteritis: rotaviruses, caliciviruses and astroviruses - Dr. Reuter Gábor Kamilló
• 31. Arenaviruses (LCM, Lassa, Junin, Machupo, Guanarito, Sabia, Lujo); Bunyaviruses (Hantaviruses, CCHF, Rift Valley, SFTS, Sandfly fever) - Dr. Reuter Gábor Kamilló
• 32. Filoviruses (Marburgvirus, Ebolavirus); Flaviviruses (tick-borne encephalitis, West-Nile virus, yellow fever, Dengue and Zika virus); Togaviruses (chikungunya); Rhabdoviruses (rabies) - Dr. Reuter Gábor Kamilló
• 33. HIV/AIDS and other human retroviruses (HTLV-I, HTLV-II) - Dr. Reuter Gábor Kamilló
• 34. Antiviral therapy - Dr. Reuter Gábor Kamilló
• 35. Defence mechanisms on the body surfaces, skin and mucosal immunity, lymphocyte homing - Dr. Polgár Beáta
• 36. Defence against viruses and bacteria - Dr. Polgár Beáta
• 37. Defence against fungi and parasites - Dr. Polgár Beáta
• 38. Immunoprophylaxis, active and passive immunization, vaccines I. - Dr. Szereday László
• 39. Immunoprophylaxis, active and passive immunization, vaccines II - Dr. Szereday László
• 40. Hypersensitivity, autoimmunity - Dr. Polgár Beáta
• 41. Immunological tolerance - Dr. Szereday László
• 42. Probiotics, prebiotics - immunity - Dr. Polgár Beáta

Practices

• 1. Introduction, safety regulations. The microscope, native and stained preparations
• 2. Introduction, safety regulations. The microscope, native and stained preparations
• 3. Introduction, safety regulations. The microscope, native and stained preparations
• 4. Introduction, safety regulations. The microscope, native and stained preparations
• 5. Cultivation of bacteria, media
• 6. Cultivation of bacteria, media
• 7. Cultivation of bacteria, media
• 8. Cultivation of bacteria, media
• 9. Biochemical reaction in the identification
• 10. Biochemical reaction in the identification
• 11. Biochemical reaction in the identification
• 12. Biochemical reaction in the identification
• 13. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 14. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 15. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 16. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 17. Serology I
• 18. Serology I
• 19. Serology I
• 20. Serology I
• 21. Serology II, Molecular diagnostics
• 22. Serology II, Molecular diagnostics
• 23. Serology II, Molecular diagnostics
• 24. Serology II, Molecular diagnostics
• 25. Diagnostic virology
• 26. Diagnostic virology
• 27. Diagnostic virology
• 28. Diagnostic virology

Seminars

Reading material

Obligatory literature

Dr. Patrick R. Murray, Dr. Ken S. Rosenthal, and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 8th edition, Elsevier Saunders 2016 ISBN:9780323299565

Literature developed by the Department

Lectures on the Neptun

Notes

Department's website

Recommended literature

Michael Barer, Will Irving (eds.): Medical Microbiology 19e, Elsevier Churchill Livingstone, 2018, ISBN: 9780702072000
Carroll KC, Butel JS, Morse SA, Mitzner T. Jawetz, Melnick, and Adelberg's: Medical Microbiology, 27th edition, Lange Medical Book,McGraw-Hill Education - Europe 2015, ISBN:9780071824989
F.H. Kayser, K.A. Bienz, J. Eckert, R.M. Zinkernagel: Medical Microbiology, Thieme Stuttgart 2005, ISBN: 3-13-131991-7
A.K. Abbas, A.H. Lichtman, S. Pillai: Cellular and Molecular Immunology, 7th edition, Elsevier Saunders, 2015, ISBN 978-1-43777-1528-6
Galdwinn M, Trattler W.: Clinical Microbiology Made Ridiculously Simple, 6th edition, MedMaster Inc. 2011, ISBN: 978-1-935660156

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

-

Making up for missed classes

The Department insists on the active participation in all the practices, since necessary knowledge and skills to take and handle microbiological samples can only be mastered there. In order to have the grade book signed, the student missing any practicals is expected to make arrangements with groups other than his/her own to cover the subject of that particular practical.

Exam topics/questions

THE WRITTEN EXAM CONSISTS OF MULTIPLE CHOICE QUESTIONS covering 4 separate topics. A minimum score of each individual topic must be achieved for passing.

Examiners

• Dr. Bátai Istvánné (Dr. Kerényi Monika)
• Dr. Emődy Levente
• Dr. Kocsis Béla
• Dr. Polgár Beáta
• Dr. Reuter Gábor Kamilló
• Dr. Szereday László
• Dr. Tigyi Zoltán

Instructor / tutor of practices and seminars

• Dr. Bátai Istvánné (Dr. Kerényi Monika)
• Dr. Kocsis Béla
• Dr. Mestyán Gyula
• Dr. Polgár Beáta
• Dr. Schneider György József
• Dr. Szereday László
• Dr. Tigyi Zoltán