Student Researchers' Society Topics

Acquired colistin resistance in Enterobacteriaceae (research work)

The precise identification of cultured microorganisms is crucial for the treatment of patients. MALDI-TOF mass spectrometry has revolutionized clinical microbiology as it makes the identification of bacteria and yeasts much easier, faster and more accurate as compared to conventional methods. Identification of molds with MALDI-TOF mass spectrometry often requires complicated protocols, and the results are less satisfying. The aim of the research work is to increase the rate of successful identification of molds and to seek for new applications of mass spectrometry in clinical mycology.

3D printing, or Additive Manufacturing (AM), has become a revolutionary technology in the biomedical field, offering customization, personalization, and on-demand production. The aim of the research is to assess the biocompatibility (ensuring the materials are safe for use in medical applications) and antimicrobial properties of different 3D printed materials.

Comparison of the effect of different antiseptics used on polymethyl methacrylate dentures with Candida biofilm

Co-supervisor: Dr. CABAI-TANICS, Tímea

Maternal immune tolerance is essential for successful implantation and maintenance of early pregnancy. During implantation, maternal immune recognition of the  embryo occurs at the contact zone between the trophoblast and the maternal endometrium, where tightly regulated immune modulation allows acceptance of the semi-allogeneic conceptus. Increasing evidence suggests that the developing embryo may influence the maternal immune environment through the release of soluble signaling molecules.

In this project, culture media of embryos collected during in vitro fertilization (IVF) procedures will be analyzed for the presence of soluble immune checkpoint ligands (e.g., PD-L1, PD-L2, Galectin-9 and related molecules). The soluble ligands will be detected by flow cytometry using fluorochrom-labeled antibodies, allowing quantitative characterization of the checkpoint-ligand profile of individual embryos and correlation with clinical outcome.

The primary objective is to determine whether embryos that successfully implant exhibit a distinct soluble checkpoint-ligand signature compared with embryos associated with failed implantation or early pregnancy loss. Identification of such profiles may  provide mechanistic insight into the establishment of fetomaternal immune tolerance and support the development of non-invasive biomarkers for embryo selection in IVF.

The molecular epidemiology of MRSA (research work)

The molecular mechanism of carbapenem resistance in Enterobacteriaceae and in Gram negative non-fermenters(research work)