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Pathology 2 - Systemic - Organ Pathology

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Official data in SubjectManager for the following academic year: 2019-2020

Course director

Dr. Béla KAJTÁR (belakajtar@yahoo.com), assistant professor

Department of Pathology

Subject data

Code of subject: OAP-PA2-T  |  8 credit  |  General Medicine |  Pre-clinical module  |  spring

Prerequisites: OAP-PA1-T completed

Exam course: yes

Number of hours/semester

56 lectures + 28 practices + 28 seminars = total of 112 hours

Course headcount limitations

min. 5

Available as Campus course for . Campus-faculties: ÁOK

Topic

There is a special emphasis during the course on the clinicopathological view of the diseases, i.e., understanding the relationship of the clinical symptoms, macroscopical and microscopical changes of the diseased organs. By the end of the academic year, a basic clinicopathological affinity and competence in differential diagnosis is required of the students. Fundamentals and major examples of specific, organ pathology are discussed. The systemic pathology course involves the major fields of organ pathology not discussed in Pathology 1: dermatopathology, hematopathology, pathology of the gastrointestinal tract, liver, biliary tract, pancreas, kidney, male and female genital tract, skeletal system, endocrine system and soft tissues pathology. Cardiovascular pathology and pathology of the respiratory tract have been discussed during Pathology 1 course.
The main educational task of the subject:
The pathology course will form the basis for later clinical studies by teaching organ specific pathology knowledge, including the etiology and pathomechanism of diseases and the entire spectrum of pathological diagnostics from macroscopy and microscopy to special ancillary techniques (ultrastructural analysis, molecular pathology) with their clinical relevance.

Lectures

  • 1. Congenital malformations of face, inflammatory changes, tumor-like conditions and tumours of the oral cavity - Dr. Bogner Barna István
  • 2. Inflammatory diseases and tumours of the salivary glands - Dr. Bogner Barna István
  • 3. Congenital and acquired diseases as well as tumors of the oesophagus - Dr. Bogner Barna István
  • 4. Pathology of the stomach - Dr. Bogner Barna István
  • 5. Pathology of the small intestines - Dr. Bogner Barna István
  • 6. Pathology of the colon and rectum - Dr. Bogner Barna István
  • 7. Circulatory disorders of the liver. Non-viral inflammations in the liver. Drug hepatopathies - Dr. Pajor László
  • 8. Acute viral hepatitis - Dr. Pajor László
  • 9. Chronic viral hepatitides - Dr. Pajor László
  • 10. Cirrhosis and hepatic failure - Dr. Pajor László
  • 11. Tumor-like conditions and true neoplasia of the liver - Dr. Pajor László
  • 12. Pathology of the extrahepatic bile ducts and exocrine pancreas - Dr. Pajor László
  • 13. Renal failure - Dr. Kereskai László
  • 14. Cystic diseases of the kidney - Dr. Kereskai László
  • 15. Pathogenesis and classification of glomerulonephritides - Dr. Kereskai László
  • 16. Tubulointerstitial and vascular diseases - Dr. Kereskai László
  • 17. Renal neoplasms - Dr. Kereskai László
  • 18. Pathology of the bladder and ureter - Dr. Kereskai László
  • 19. Ontogenesis of the lymphoid cells, lymphoid cell populations - Dr. Kajtár Béla
  • 20. Reactive lymph node changes - Dr. Kajtár Béla
  • 21. B-cell lymphomas - Dr. Kajtár Béla
  • 22. T/NK cell lymphomas - Dr. Kajtár Béla
  • 23. Hodgkin lymphoma - Dr. Kajtár Béla
  • 24. Haemopoesis. Myeloproliferative neoplasms - Dr. Kajtár Béla
  • 25. Acut myloid leukaemias and myelodysplastic syndromes - Dr. Kajtár Béla
  • 26. Malformations of the brain, hydrocephalus, cerebral edema - Dr. Kajtár Béla
  • 27. Vascular disorders of the central nervous system - Dr. Kajtár Béla
  • 28. Dementias, neurodegenerative disorders. - Dr. Kajtár Béla
  • 29. Demyelinisation disorders, multiple sclerosis. - Dr. Kajtár Béla
  • 30. Inflammations of the central nervous system - Dr. Kajtár Béla
  • 31. Central nervous system tumors - Dr. Kajtár Béla
  • 32. Pathological conditions of the hypothalamo-hypophyseal system - Dr. Tornóczki Tamás
  • 33. Pathology of the thyroid gland (developmental abnormalities, hyperplasia, thyreoiditis, tumours) - Dr. Tornóczki Tamás
  • 34. Pathology of the parathyroid glands - Dr. Tornóczki Tamás
  • 35. Pathology of the adrenal gland. MEN - Dr. Tornóczki Tamás
  • 36. Pathogenesis of the soft tissue tumors. Fibrous, fibrohistiocyter neoplasms of the soft tissues and tumors of the fat tissue - Dr. Tornóczki Tamás
  • 37. Tumors of the smooth- and striated muscle. Tumors of the peripherial nerves, PNET. Synovial sarcoma. - Dr. Tornóczki Tamás
  • 38. Pathology of the testis and its appendices - Dr. Semjén Dávid
  • 39. Pathology of the prostate - Dr. Semjén Dávid
  • 40. Pathology of the penis - Dr. Semjén Dávid
  • 41. Pathology of the vulva and the vagina - Dr. Kálmán Endre
  • 42. Inflammatory lesions of the female genital tract - Dr. Kálmán Endre
  • 43. Sexualy transmitted diseases - Dr. Kálmán Endre
  • 44. Pathology of the cervix - Dr. Kálmán Endre
  • 45. Pathology of the uterine corpus - Dr. Kálmán Endre
  • 46. Pathology of the ovaries - Dr. Kálmán Endre
  • 47. Pathology of pregnancy I (abnormalities of implantation, gestosis, trophoblastic tumours) - Dr. Kálmán Endre
  • 48. Pathology of pregnancy II (transplacental infections, chromosomal aberrations) - Dr. Kálmán Endre
  • 49. Pathology of the breast - Dr. Kálmán Endre
  • 50. Dermathopathology I - Dr. Gyömörei Csaba
  • 51. Dermathopathology II - Dr. Gyömörei Csaba
  • 52. Dermathopathology III - Dr. Gyömörei Csaba
  • 53. Dermatopathology IV - Dr. Gyömörei Csaba
  • 54. Hereditary, inflammatory and metabolic bone diseases - Dr. Kereskai László
  • 55. Benign bone tumors - Dr. Kereskai László
  • 56. Malignant bone tumors - Dr. Kereskai László

Practices

  • 1. One autopsy case per week, with detailed clinicopathological discussion
  • 2. One autopsy case per week, with detailed clinicopathological discussion
  • 3. One autopsy case per week, with detailed clinicopathological discussion
  • 4. One autopsy case per week, with detailed clinicopathological discussion
  • 5. One autopsy case per week, with detailed clinicopathological discussion
  • 6. One autopsy case per week, with detailed clinicopathological discussion
  • 7. One autopsy case per week, with detailed clinicopathological discussion
  • 8. One autopsy case per week, with detailed clinicopathological discussion
  • 9. One autopsy case per week, with detailed clinicopathological discussion
  • 10. One autopsy case per week, with detailed clinicopathological discussion
  • 11. One autopsy case per week, with detailed clinicopathological discussion
  • 12. One autopsy case per week, with detailed clinicopathological discussion
  • 13. One autopsy case per week, with detailed clinicopathological discussion
  • 14. One autopsy case per week, with detailed clinicopathological discussion
  • 15. One autopsy case per week, with detailed clinicopathological discussion
  • 16. One autopsy case per week, with detailed clinicopathological discussion
  • 17. One autopsy case per week, with detailed clinicopathological discussion
  • 18. One autopsy case per week, with detailed clinicopathological discussion
  • 19. One autopsy case per week, with detailed clinicopathological discussion
  • 20. One autopsy case per week, with detailed clinicopathological discussion
  • 21. One autopsy case per week, with detailed clinicopathological discussion
  • 22. One autopsy case per week, with detailed clinicopathological discussion
  • 23. One autopsy case per week, with detailed clinicopathological discussion
  • 24. One autopsy case per week, with detailed clinicopathological discussion
  • 25. One autopsy case per week, with detailed clinicopathological discussion
  • 26. One autopsy case per week, with detailed clinicopathological discussion
  • 27. One autopsy case per week, with detailed clinicopathological discussion
  • 28. One autopsy case per week, with detailed clinicopathological discussion

Seminars

  • 1. Week 1: Pathology of the gastrointestinal tract 1 - Preparations: Esophageal diverticulum, Esophageal carcinoma, Penetrating, chronic, ventricular ulcer (penetrating into pancreas), Exophytic carcinoma of the stomach, Pyloric carcinoma Slides: Pleiomorphic adenoma, Helicobacter pylori infection (Warthin-Starry), Coeliac disease - subtotal/total villus atrophy (Marsh 3c)
  • 2. Week 1: Pathology of the gastrointestinal tract 1 - Preparations: Esophageal diverticulum, Esophageal carcinoma, Penetrating, chronic, ventricular ulcer (penetrating into pancreas), Exophytic carcinoma of the stomach, Pyloric carcinoma Slides: Pleiomorphic adenoma, Helicobacter pylori infection (Warthin-Starry), Coeliac disease - subtotal/total villus atrophy (Marsh 3c)
  • 3. Week 2: Pathology of the gastrointestinal tract 2 - Preparations: Crohn's disease, Colonic diverticulosis, Ulcerative colitis, Rectal polyp (repetition), Rectal adenocarcinoma (repetition), Linitis plastica and Krukenberg tumor Slides: Crohn's disease, Carcinoid of the appendix, Rectal adenocarcinoma
  • 4. Week 2: Pathology of the gastrointestinal tract 2 - Preparations: Crohn's disease, Colonic diverticulosis, Ulcerative colitis, Rectal polyp (repetition), Rectal adenocarcinoma (repetition), Linitis plastica and Krukenberg tumor Slides: Crohn's disease, Carcinoid of the appendix, Rectal adenocarcinoma
  • 5. Week 3: Pathology of liver, bile ducts, pancreas - Preparations: Echinococcus cysts in the liver, Macronodular (postnecrotic) cirrhosis, Focal nodular hyperplasia, Hepatocellular carcinoma, Cholelithiasis, chronic cholecystitis and empyema, Adenocarcinoma of the gall bladder with multiple liver metastases, Pancreatic carcinoma Slides: HBs-antigen positivism (Shikata-orcein), Alcoholic hepatitis, Hepatocellular carcinoma in cirrhosis
  • 6. Week 3: Pathology of liver, bile ducts, pancreas - Preparations: Echinococcus cysts in the liver, Macronodular (postnecrotic) cirrhosis, Focal nodular hyperplasia, Hepatocellular carcinoma, Cholelithiasis, chronic cholecystitis and empyema, Adenocarcinoma of the gall bladder with multiple liver metastases, Pancreatic carcinoma Slides: HBs-antigen positivism (Shikata-orcein), Alcoholic hepatitis, Hepatocellular carcinoma in cirrhosis
  • 7. Week 4: Nephro- and uropathology - Preparations: Polycystic kidney (infantile sponge kidney), Polycystic kidney (adult type), Pyelonephritis abscedens. Necrosis of papilla, Nephrosclerosis, Congenital hydronephrosis, Clear cell carcinoma of kidney, Wilms' tumor, Urothelial carcinoma of the bladder Slides: Rapidly progressive GN with crescents, Hyalinised glomeruli, Kimmelstiel Wilson syndrome, Clear cell carcinoma of the kidney, Urothelial carcinoma of the renal pelvis
  • 8. Week 4: Nephro- and uropathology - Preparations: Polycystic kidney (infantile sponge kidney), Polycystic kidney (adult type), Pyelonephritis abscedens. Necrosis of papilla, Nephrosclerosis, Congenital hydronephrosis, Clear cell carcinoma of kidney, Wilms' tumor, Urothelial carcinoma of the bladder Slides: Rapidly progressive GN with crescents, Hyalinised glomeruli, Kimmelstiel Wilson syndrome, Clear cell carcinoma of the kidney, Urothelial carcinoma of the renal pelvis
  • 9. Week 5: Hematopathology - Preparations: Burkitt's lymphoma, Multiple myeloma, CML - extreme splenomegaly, Lymphomatous polyposis of small and large intestine Slides: Toxoplasma lymphadenitis, Follicular lymphoma, CLL/SLL infiltration in lymph node, Diffuse large B-cell lymphoma, Hodgkin lymphoma, CML, CP smear
  • 10. Week 5: Hematopathology - Preparations: Burkitt's lymphoma, Multiple myeloma, CML - extreme splenomegaly, Lymphomatous polyposis of small and large intestine Slides: Toxoplasma lymphadenitis, Follicular lymphoma, CLL/SLL infiltration in lymph node, Diffuse large B-cell lymphoma, Hodgkin lymphoma, CML, CP smear
  • 11. Week 6: Neuropathology 1 - Preparations: Epidural haemorhage, Subdural haemorhage, Subarachnoidal haemorhage, Secondary hemorrhage of the pons, hematocephalus Slides: Prion disease, spongioform encephalopathy
  • 12. Week 6: Neuropathology 1 - Preparations: Epidural haemorhage, Subdural haemorhage, Subarachnoidal haemorhage, Secondary hemorrhage of the pons, hematocephalus Slides: Prion disease, spongioform encephalopathy
  • 13. Week 7: Neuropathology 2 - Preparations: Meningioma, Glioblastoma, Medulloblastoma, Multiple brain metastases, Cerebral atrophy (repetition), Multiple sclerosis Slides: Oligodendroglioma, Glioblastoma, Senile plaques and neurofibrillar degeneration
  • 14. Week 7: Neuropathology 2 - Preparations: Meningioma, Glioblastoma, Medulloblastoma, Multiple brain metastases, Cerebral atrophy (repetition), Multiple sclerosis Slides: Oligodendroglioma, Glioblastoma, Senile plaques and neurofibrillar degeneration
  • 15. Week 8: Endocrinopathology and pathology of soft tissues 1 - Preparations: Craniopharyngeoma, Suprarenal cortical adenoma, Papillary carcinoma of the thyroid gland Slides: Subacut granulomatous thyreoiditis (De Quervain), Papillary carcinoma of the thyroid, Graves disease, Hashimoto thyreoiditis
  • 16. Week 8: Endocrinopathology and pathology of soft tissues 1 - Preparations: Craniopharyngeoma, Suprarenal cortical adenoma, Papillary carcinoma of the thyroid gland Slides: Subacut granulomatous thyreoiditis (De Quervain), Papillary carcinoma of the thyroid, Graves disease, Hashimoto thyreoiditis
  • 17. Week 9: Endocrinopathology and pathology of soft tissues 1 - Slides: Parathyroid adenoma, Phaeochromocytoma, Leiomyosarcoma, Myxoid liposarcoma
  • 18. Week 9: Endocrinopathology and pathology of soft tissues 1 - Slides: Parathyroid adenoma, Phaeochromocytoma, Leiomyosarcoma, Myxoid liposarcoma
  • 19. Week 10: Pathology of male genital tract - Preparations: Prostate adenocarcinoma, Chronic epididymitis. Hydrokele. Atrophia of the testes, Mixed germ- cell tumor; seminoma and teratoma, Penal carcinoma Slides: Prostatic adenocarcinoma, Seminoma, Mixed germ cell tumor: teratoma and embryonal carcinoma
  • 20. Week 10: Pathology of male genital tract - Preparations: Prostate adenocarcinoma, Chronic epididymitis. Hydrokele. Atrophia of the testes, Mixed germ- cell tumor; seminoma and teratoma, Penal carcinoma Slides: Prostatic adenocarcinoma, Seminoma, Mixed germ cell tumor: teratoma and embryonal carcinoma
  • 21. Week 11 Pathology of female genital tract 1 - Preparations: Carcinoma of the cervix, Endometrial polyp, Carcinoma of the uterine corpus, Mucinous, multilocular cystadenoma of the ovary, Thecofibroma of the ovary, Dermoid cyst (repetition), Dysgerminoma Slides: Endometrial adenocarcinoma (curettage), Serous papillary cystadenocarcinoma of the ovary
  • 22. Week 11 Pathology of female genital tract 1 - Preparations: Carcinoma of the cervix, Endometrial polyp, Carcinoma of the uterine corpus, Mucinous, multilocular cystadenoma of the ovary, Thecofibroma of the ovary, Dermoid cyst (repetition), Dysgerminoma Slides: Endometrial adenocarcinoma (curettage), Serous papillary cystadenocarcinoma of the ovary
  • 23. Week 12: Pathology of female genital tract 2 - Preparations: Hydatidiform mole, Fibroadenoma of the breast (repetition), Carcinoma of the breast (repetition), Mastitis carcinomatosa, Paget's disease, Serous papillary adenocarcinoma of fallopian tube, Teratoma of the ovary (embryonal) Slides: Hydatidiform mole, Intraductal papilloma, Paget-disease, Invasive ductal carcinoma, Mucinous carcinoma
  • 24. Week 12: Pathology of female genital tract 2 - Preparations: Hydatidiform mole, Fibroadenoma of the breast (repetition), Carcinoma of the breast (repetition), Mastitis carcinomatosa, Paget's disease, Serous papillary adenocarcinoma of fallopian tube, Teratoma of the ovary (embryonal) Slides: Hydatidiform mole, Intraductal papilloma, Paget-disease, Invasive ductal carcinoma, Mucinous carcinoma
  • 25. Week 13: Dermatopathology - Preparations: Melanoma of the eye, Metastasizing melanoma, Cylindromatosis (turban tumour) Slides: Seborrhoeic keratosis, Basal cell carcinoma, Nodular melanoma, Melanocytic nevus and superficially spreading melanoma, Bullous pemphigoid, Psoriasis
  • 26. Week 13: Dermatopathology - Preparations: Melanoma of the eye, Metastasizing melanoma, Cylindromatosis (turban tumour) Slides: Seborrhoeic keratosis, Basal cell carcinoma, Nodular melanoma, Melanocytic nevus and superficially spreading melanoma, Bullous pemphigoid, Psoriasis
  • 27. Week 14: Pathology of the bone - Preparations: Osteogenic sarcoma, Chondrosarcoma Slides: Giant cell tumor of bone (osteoclastoma)
  • 28. Week 14: Pathology of the bone - Preparations: Osteogenic sarcoma, Chondrosarcoma Slides: Giant cell tumor of bone (osteoclastoma)

Reading material

Obligatory literature

Literature developed by the Department

Lecture handouts are available on the webpage of the deparment.

Notes

Recommended literature

S. L. Robins, V. Kumar: Basic Pathology, 9th edition, Saunders Company, 2012

Conditions for acceptance of the semester

Absences exceeding 15% each of the histopathology and autopsy practical classes will result in denial of signing the gradebook. Maximum absence: two (2x45 min.) Histology and two (2x45 min.) Autopsy practises.

Mid-term exams

The capability of recognising diseases on the basis of gross morphology, interpreting basic clinicopathology and giving differential diagnostics will be examined during the regular autopsy classes of the last (14th) weeks of the second semester. A student whose performance is not found at least satisfactory will get one additional macropreparation during the final exam.
One macropreparation and one histological preparation as well as two theoretical questions will be given to the students during the final examination at the end of the course. The theoretical questions include the entire organ pathology, cardiovascular pathology and pathology of the respiratory tract are included.

Making up for missed classes

Making up for missed classes
Each missed seminar has to be made up for with another group in the same week.

Exam topics/questions

PREPARATIONS
I. PATHOLOGY OF THE GASTROINTESTINAL TRACT
1. Esophageal diverticulum
2. Esophageal carcinoma
3. Penetrating, chronic, ventricular ulcer (penetrating into pancreas)
4. Exophytic carcinoma of the stomach
5. Pyloric carcinoma
6. Crohn's disease
7. Colonic diverticulosis
8. Ulcerative colitis
9. Rectal polyp (repetition)
10. Rectal adenocarcinoma (repetition)
11. Linitis plastica and Krukenberg tumor

II. PATHOLOGY OF LIVER, BILIARY TRACT, PANCREAS
12. Echinococcus cysts in the liver
13. Macronodular (postnecrotic) cirrhosis
14. Focal nodular hyperplasia
15. Hepatocellular carcinoma
16. Cholelithiasis, chronic cholecystitis and empyema

III. NEPHRO AND UROPATHOLOGY
17. Polycystic kidney (infantile sponge kidney)
18. Polycystic kidney (adult type)
19. Nephrosclerosis
20. Congenital hydronephrosis
21. Clear cell carcinoma of kidney
22. Wilms' tumor
23. Urothelial carcinoma of the bladder

IV. HEMATOPATHOLOGY
24. Burkitt's lymphoma
25. Multiple myeloma
26. CML extreme splenomegaly
27. Lymphomatous polyposis of small and large intestine

V. NEUROPATHOLOGY
28. Epidural haemorhage
29. Subdural haemorhage
30. Subarachnoidal haemorhage
31. Secondary hemorrhage of the pons, hematocephalus
32. Meningioma
33. Glioblastoma
34. Medulloblastoma
35. Multiple brain metastases
36. Cerebral atrophy (repetition)
37. Multiple sclerosis

VI. ENDOCRINOPATHOLOGY AND PATHOLOGY OF SOFT TISSUES
39. Craniopharyngeoma
40. Suprarenal cortical adenoma
41. Papillary carcinoma of the thyroid gland

VII. PATHOLOGY OF MALE GENITAL TRACT
42. Prostate adenocarcinoma
43. Mixed germ cell tumor; seminoma and teratoma
44. Penal carcinoma

VIII. PATHOLOGY OF FEMALE GENITAL TRACT
45. Carcinoma of the cervix
46. Endometrial polyp
47. Carcinoma of the uterine corpus
48. Serous papillary adenocarcinoma of fallopian tube
49. Mucinous, multilocular cystadenoma of the ovary
50. Teratoma of the ovary (embryonal)
51. Dermoid cyst (repetition)
52. Thecofibroma
53. Hydatidiform mole
54. Fibroadenoma of the breast (repetition)
55. Carcinoma of the breast (repetition)
56. Paget's disease

IX. DERMATOPATHOLOGY
57. Melanoma of the eye
58. Metastasizing melanoma
59. Cylindromatosis (turban tumour)

X. PATHOLOGY OF BONES
59. Osteogenic sarcoma
60. Chondrosarcoma


SLIDES
I. PATHOLOGY OF THE GASTROINTESTINAL TRACT
1. Pleiomorphic adenoma
2. Helicobacter pylori infection (Warthin-Starry)
3. Celiac disease - subtotal/total villus atrophy (Marsh 3c)
4. Crohn's disease
5. Neuroendocrine tumor (carcinoid) of the appendix
6. Rectal adenocarcinoma

II. PATHOLOGY OF LIVER, BILE TRACT, PANCREAS
7. Congenital hepatic fibrosis
8. HBs antigen positivity (Shikata orcein)
9. Chronic hepatitis
10. Hepatocellular carcinoma in cirrhosis

III. NEPHRO AND UROPATHOLOGY
11. Rapidly progressive GN with crescents
12. Hyalinised glomeruli
13. Kimmelstiel Wilson syndrome
14. Clear cell carcinoma of the kidney
15. Urothelial carcinoma of the renal pelvis

IV. HAEMATOPATHOLOGY
16. Toxoplasma lymphadenitis
17. Follicular lymphoma
18. CLL/SLL infiltration in lymph node
19. Diffuse large B cell lymphoma
20. Hodgkin lymphoma
21. CML, CP smear

V. NEUROPATHOLOGY
22. Oligodendroglioma
23. Glioblastoma
24. Senile plaques and neurofibrillar degeneration
25. Prion disease, spongiform encephalopathy

VI. ENDOCRINOPATHOLOGY AND PATHOLOGY OF SOFT TISSUES
26. Subacute granulomatous thyreoiditis (De Quervain)
27. Papillary carcinoma of the thyroid
28. Graves disease
29. Hashimoto thyreoiditis
30. Parathyroid adenoma
31. Pheochromocytoma
32. Leiomyosarcoma
33. Myxoid liposarcoma

VII. PATHOLOGY OF MALE GENITAL TRACT
34. Prostatic adenocarcinoma
35. Seminoma
36. Mixed germ cell tumor

VIII. PATHOLOGY OF FEMALE GENITAL TRACT
37. Endometrial adenocarcinoma (curettage)
38. Serous papillary cystadenocarcinoma of the ovary
39. Hydatidiform mole
40. Complex sclerosing lesion
41. Paget disease
42. Invasive ductal carcinoma


IX. DERMATOPATHOLOGY
43. Seborrhoeic keratosis
44. Basal cell carcinoma
45. Nodular melanoma
46. Melanocytic nevus and superficially spreading melanoma
47. Bullous pemphigoid
48. Psoriasis

X. PATHOLOGY OF BONES
49. Giant cell tumor of bone (osteoclastoma)


THEORETICAL QUESTIONS
I. PATHOLOGY OF THE GASTROINTESTINAL TRACT
1. Developmental malformations of the face. Inflammatory and tumorous diseases of the oral cavity
2. Pathology of the salivary glands
3. Diseases of the oesophagus
4. Inflammatory and ulcerative disorders of the stomach
5. The benign and malignant tumours of the stomach
6. Malformations of the small intestine. Malabsorption. Tumors of the small intestine
7. Diverticulosis of the colon. Pathology of colonic polyps
8. Crohn's disease and ulcerative colitis
9. Colorectal malignancies and their relationship to polypous lesions
10. Diseases of the appendix and the peritoneum (appendicitis, mucocele, peritonitis, retroperitoneal sclerosis, pseudomyxoma of the peritoneum).

II. PATHOLOGY OF LIVER, BILE DUCTS, PANCREAS
11. Hepatic lesions caused by circulatory disorders. Nonviral inflammatory diseases of the liver. Drug hepatopathies.
12. Acute viral hepatitis (aetiology, pathomorphology, complicated forms)
13. Chronic viral hepatitis (aetiology, types; pathomorphology and differential diagnostics, detection of virus associated antigens and their significance)
14. Cirrhosis and hepatic failure
15. Tumours and tumorlike conditions of the liver
16. Cholelithiasis (aetiology and complications) and pathology of the extrahepatic biliary tract
17. Acute and chronic pancreatitis. Tumours of the pancreas

III. NEPHRO AND UROPATHOLOGY
18. Renal failure, uraemia. Congenital malformations and cystic diseases of the kidney.
19. Glomerulonephritis: classification according to clinical symptoms. Histologic alterations in glomerulonephritides
20. Nephrosis syndrome: minimal change, membranous glomerulonephritis, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis.
21. IgA nephropathy, chronic glomerulonephritis. Glomerular lesions associated with systemic disorders (SLE, Henoch-Schönlein purpura, Wegener s granulomatosis, amyloidosis)
22. Nephritic syndrome (acute poststreptococcal glomerulonephritis). Rapidly progressive glomerulonephritis.
23. Acute tubular necrosis (ischaemic and toxic). Druginduced (hypersensitive) interstitial nephritis, analgetic nephropathy, urate nephropathy. Acute and chronic pyelonephritis
24. Benign and malignant nephrosclerosis and diffuse cortical necrosis. Diabetic nephropathy.
25. Renal tumours (oncocytoma, renocellular cancer, Wilms tumor, urothelial carcinoma of the renal pelvis)
26. Cystitides, tumours of the bladder and ureter

IV. HAEMATOPATHOLOGY
27. Reactive lymph node changes
28. Indolent B cell lymphomas (FL, CLL, MCL, MZL)
29. High grade B cell lymphomas (BL, DLBCL). Plasma cell neoplasms
30. Hodgkin lymphoma
31. T/NK cell lymphomas.
32. Nonneoplastic bone marrow disorders (anaemia, leukocytosis and leukopenia, thrombocytopenia)
33. AML and MDS
34. Myeloproliferative neoplasms

V. NEUROPATHOLOGY
35. Cerebral edema, hydrocephalus, malformations of the brain
36. Dementias and neurodegenerative disorders
37. Demyelinisation disorders
38. Infectious diseases of the CNS
39. Cerebrovascular diseases, intracranial haemorhages
40. Glial central nervous system tumors
41. Nonglial central nervous system tumors

VI. ENDOCRINOPATHOLOGY AND PATHOLOGY OF SOFT TISSUES
42. Anterior lobe pituitary tumours and their consequences. Posterior lobe syndromes. Disorders associated with hypopituarism (Sheehan’s syndrome, chromophobic adenoma, empty sella syndrome, suprasellar tumours)
43. Inflammatory, tumorous diseases as well as disorders associated with hyperplasia of the thyroid gland.
44. Pathology of the parathyroid glands (hyperplasia, adenoma, causes of hypoparathyreoidism). Multiple endocrine neoplasms.
45. Causes and clinical consequences of hyperplasia and atrophy of the suprarenal gland. Cortical tumours of the suprarenal gland (morphology, clinical syndromes) Cortical insufficiency of the suprarenal gland. Tumors of the adrenal medulla.
46. Pathogenesis and frequency of soft tissue tumours. Fibrous tumours and tumourlike lesions. Fibrosarcoma. Fibromatoses. Socalled fibrohistiocytic tumors.
47. Tumours of adipose tissue and peripheral nerves, synovial sarcoma.
48. Tumours of smooth and striated muscle (leiomyoma, leiomyosarcoma, rhabdomyoma and rhabdomyosarcoma, types)

VII. PATHOLOGY MALE GENITAL TRACT
49. Congenital malformations, inflammations and tumors of the penis
50. Prostatitides. Hyperplasia of the prostate, complications
51. Tumours of the prostate (pathogenesis, morphology, screening, diagnosis)
52. Cryptorchism, inflammations of the testis, pathology of the testicular capsule and the epididymis
53. Testicular tumours, classification, tumour markers

VIII. PATHOLOGY OF FEMALE GENITAL TRACT
54. Pathology of vulva and vagina. Venereal infections.
55. Inflammations, tumourlike lesions and tumours of the cervix. Carcinoma of the cervix (pathogenesis, pathomorphology, screening).
56. Adenomyosis and endometriosis. Dysfunctional bleedings. Endometrial hyperplasia. Endometritises.
57. Pathology of the uterine corpus and the fallopian tube
58. Cysts and tumours of the ovaries (surface epithelial, germ cell, sex cordstromal tumours, tumours, metastases)
59. Pathology of pregnancy I (implantation disorders, gestosis, trophoblastic tumours)
60. Pathology of pregnancy II (transplacental infections, chromosomal aberrations)
61. Mastitides (lactational, ductus ectasia, fat necrosis, galactocele). Mastopathies (fibrocystic change). Fibroepthelial tumours.
62. Breast carcinoma. Pathogenesis, types, prognosis.

IX. DERMATOPATHOLOGY
63. Melanocytic lesions
64. Epithelial tumours of the skin
65. Inflammatory skin diseases

X. PATHOLOGY OF BONES
66. Hereditary, inflammatory and metabolic bone diseases
67. Benign and malignant bone tumours

XI. CARDIOVASCULAR PATHOLOGY
68. Angina pectoris, chronic ischemic heart disease, sudden cardiac death.
69. Clinicopathology of acute myocardial infarction.
70. Pathology of the valvular disorders (inflammatory and degenerative ones).
71. Cardiomyopathies. Tumors and tumor-like conditions of the heart.
72. Myocarditis. Pathology of the pericardium.
73. Congenital heart diseases.
74. Types and clinicopathology of the aneurysms.
75. Pathogenesis, classification and clinicopathology of vasculitides. Vascular tumours.

XII. PATHOLOGY OF RESPIRATORY TRACT
76. Diseases of the upper airways (inflammations, benign and malignant tumors of the sinonasal tract, inflammations and malignant tumors of the larynx)
77. Congenital anomalies of the lungs, atelectasis, acute lung injury
78. Infectious disorders of the lower airways (examples of nosocomial and community acquired pneumonia, atypical pneumonia, immunosuppression related infections)
79. General characteristics and types of chronic obstructive lung diseases
80. Chronic restrictive lung diseases I: IPF/UIP, NSIP, OP, hypersensitive pneumonitis
81. Chronic restrictive lung diseases II: pneumoconioses
82. Vascular diseases of the lung (types of pulmonary hypertension, Wegener granulomatosis, Goodpasture syndrome)
83. Malignant lung tumors
84. Pleural and mediastinal disorders

Comment: The Department of Pathology reserves the right of minor modifications in the curriculum

Examiners

  • Dr. Bogner Barna István
  • Dr. Kajtár Béla
  • Dr. Kálmán Endre
  • Dr. Kereskai László
  • Dr. Pajor László
  • Dr. Semjén Dávid
  • Dr. Smuk Gábor
  • Dr. Tornóczki Tamás
  • Dr. Vida Livia

Instructor / tutor of practices and seminars

  • Dr. Kajtár Béla
  • Dr. Kálmán Endre
  • Dr. Kaszás Bálint
  • Dr. Kereskai László
  • Dr. Pap Anita
  • Dr. Semjén Dávid
  • Dr. Vida Livia