Organic Chemistry 1 - Practice

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The aims of this course are to introduce students into several basic laboratory techniques and to demonstrate some characteristic reactions of organic compounds with various functional groups.

Lectures

Practices

• 1. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 2. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 3. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 4. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 5. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 6. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 7. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 8. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 9. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 10. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 11. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 12. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 13. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 14. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 15. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 16. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 17. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 18. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 19. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 20. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 21. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 22. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 23. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 24. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 25. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 26. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 27. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 28. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 29. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 30. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 31. 2nd written test. Characteristic reactions of amines.
• 32. 2nd written test. Characteristic reactions of amines.
• 33. 2nd written test. Characteristic reactions of amines.
• 34. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 35. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 36. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 37. Preparation of 2-iodobenzoic acid;
• 38. Preparation of 2-iodobenzoic acid;
• 39. Preparation of 2-iodobenzoic acid;
• 40. Evaluation.
• 41. Evaluation.
• 42. Evaluation.

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs, 2010.

Notes

Recommended literature

Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London, 1995.
Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed., Wiley, New York, 1994.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of all. The evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records of exercise book.

Making up for missed classes

Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Exam topics/questions

The written tests will contain the matter of practice.

Examiners

Instructor / tutor of practices and seminars

• Dr. Bognár Balázs
• Dr. Kálai Tamás