Organic Chemistry 2 - Practice

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The aims of this course are to introduce students into several basic laboratory techniques and to demonstrate some characteristic reactions of organic compounds with various functional groups.

Lectures

Practices

• 1. General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin.
• 2. General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin.
• 3. General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin.
• 4. Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.
• 5. Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.
• 6. Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.
• 7. Synthesis of benzil; Identification of 4th unknown compound.
• 8. Synthesis of benzil; Identification of 4th unknown compound.
• 9. Synthesis of benzil; Identification of 4th unknown compound.
• 10. Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid.
• 11. Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid.
• 12. Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid.
• 13. Acetylation of glucose; Identification of 5th unknown compound;
• 14. Acetylation of glucose; Identification of 5th unknown compound;
• 15. Acetylation of glucose; Identification of 5th unknown compound;
• 16. 1st written test; Synthesis of aspirin. Polarimetry.
• 17. 1st written test; Synthesis of aspirin. Polarimetry.
• 18. 1st written test; Synthesis of aspirin. Polarimetry.
• 19. Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acids and carboxylic acid derivatives.
• 20. Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acids and carboxylic acid derivatives.
• 21. Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acids and carboxylic acid derivatives.
• 22. Synthesis of lidocain (2nd step);
• 23. Synthesis of lidocain (2nd step);
• 24. Synthesis of lidocain (2nd step);
• 25. Synthesis of heterocycles I. (five membered): benzimidazole, dilantin; Characteristic tube reactions of pyridine.
• 26. Synthesis of heterocycles I. (five membered): benzimidazole, dilantin; Characteristic tube reactions of pyridine.
• 27. Synthesis of heterocycles I. (five membered): benzimidazole, dilantin; Characteristic tube reactions of pyridine.
• 28. Synthesis of heterocycles II. (six membered): 4-phenyl-5-carbethoxy-6-methyl-1,2,3,4-tetrahyropyrimidin-2-one, 4-methyl-7-hydroxycoumarine.
• 29. Synthesis of heterocycles II. (six membered): 4-phenyl-5-carbethoxy-6-methyl-1,2,3,4-tetrahyropyrimidin-2-one, 4-methyl-7-hydroxycoumarine.
• 30. Synthesis of heterocycles II. (six membered): 4-phenyl-5-carbethoxy-6-methyl-1,2,3,4-tetrahyropyrimidin-2-one, 4-methyl-7-hydroxycoumarine.
• 31. 2nd written test. Isolation of caffeine.
• 32. 2nd written test. Isolation of caffeine.
• 33. 2nd written test. Isolation of caffeine.
• 34. Isolation of quercetin and myristic acid.
• 35. Isolation of quercetin and myristic acid.
• 36. Isolation of quercetin and myristic acid.
• 37. Characteristic tube reactions of amino acids and peptides.
• 38. Characteristic tube reactions of amino acids and peptides.
• 39. Characteristic tube reactions of amino acids and peptides.
• 40. Evaluation.
• 41. Evaluation.
• 42. Evaluation.

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs, 2010.

Notes

Recommended literature

Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London, 1995.
Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed., Wiley, New York, 1994.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of all. The evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records of exercise book.

Making up for missed classes

Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Exam topics/questions

The written tests will contain the matter of practice.

Examiners

Instructor / tutor of practices and seminars

• Dr. Bognár Balázs
• Dr. Kálai Tamás