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PAP, Marianna

PAP, Marianna

M.D., Ph.D.

Telefon: +36 72 536001/31565

Supervisor of the following TDK topics

Supervisor: PAP, Marianna

Our research team focuses on the role of the CREB transcription factor in the survival, programmed cell death and neuronal differentiation of cell cultures.  The CREB transcription factor regulates the transcription of at least 2000 genes of the human genome (approximately 10% of the total number of genes). Its role has been proven in learning, in several neurodegenerative diseases and in the survival of neurons. The research covers the following two areas of interest.

Investigation of alcohol-stress
The proper mechanism of alcoholism and alcohol-stress has not been known in details. The aim of the research is to identify and characterize the alcohol-induced signaling pathways, to explore the relationship between CREB and alcoholism.

Exploration of endoplasmic reticulum stress
Cells can undergo programmed cell death p53-independently due to extensive endoplasmic reticulum stress. Endoplasmic reticulum stress has a role in the development of several diseases, and its selective induction might be a promising target of the therapy of p53-negative tumors. The experiments investigate the role of the CREB protein in endoplasmic reticulum stress. The members of the research team: András Balogh MD, Ibolya Koloszár, Kazushi Jinno, Mária Németh, Csilla Szigeti. We work in cooperation with: Max-Delbrück Center, Berlin and School of Medicine Osijek.