Data
Official data in SubjectManager for the following academic year: 2020-2021
Course director
-
Tibor Attila RAUCH
senior research fellow,
Department of Medical Biology and Central Electron Microscope Laboratory -
Number of hours/semester
lectures: 12 hours
practices: 0 hours
seminars: 0 hours
total of: 12 hours
Subject data
- Code of subject: OXFMLP-z-T
- 1 kredit
- Dentistry
- Optional modul
- autumn
-
Course headcount limitations
min. 1 – max. 50
Available as Campus course for 1 fő számára. Campus-karok: ÁOK TTK
Topic
Why are certain family members affected by tumorous diseases and others are not? Can the lifestyles of our grandparents and parents affect our health? What kind of molecular factors and mechanisms might be involved in epigenetics, including transgenerational inheritance? Is epigenetics the missing link between genetics, the environment and disease? These fundamental questions will be addressed and the latest advances of the field will be discussed. Moreover, epigenetic biomarkers and therapeutic potential of epigenetic drugs (epigenetic enzyme inhibitors) will be also covered.
Lectures
- 1. Milestones of epigenetics - from Conrad Waddington to David Allis - Dr. Rauch Tibor Attila
- 2. DNA methylation and demethylation – the first discovered epigenetic alterations - Dr. Rauch Tibor Attila
- 3. Histone protein-related epigenetic signals - Dr. Rauch Tibor Attila
- 4. Non-coding RNAs (miRNA, piRNA and lncRNA) in cell biology and pathogeneses - Dr. Rauch Tibor Attila
- 5. Epigenetic methods, including single-locus and genome-wide analysis tools - Dr. Rauch Tibor Attila
- 6. Genetic imprinting and X chromosome inactivation - Dr. Rauch Tibor Attila
- 7. Stem cell and differentiation-associated epigenetic events - Dr. Rauch Tibor Attila
- 8. Epigenetics of cancer - Dr. Rauch Tibor Attila
- 9. Epigenetics of autoimmune diseases - Dr. Rauch Tibor Attila
- 10. Epigenetic aspects of memory and neurological disorders - Dr. Rauch Tibor Attila
- 11. Epigenetic biomarkers and therapeutic interventions - Dr. Rauch Tibor Attila
- 12. Exam (oral or written) - Dr. Rauch Tibor Attila
Practices
Seminars
Reading material
Obligatory literature
-
Literature developed by the Department
PowerPoint presentation according to lectures
Notes
-
Recommended literature
Handbook of Epigenetics, 2nd Edition, Editors: Trygve Tollefsbol, eBook ISBN: 9780128054772, Hardcover ISBN: 9780128053881, Academic Press, Published Date: 7th August 2017
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Closing test
Making up for missed classes
None
Exam topics/questions
1. Milestones of epigenetics
2. DNA methylation and demethylation
3. Histone protein-related epigenetic signals
4. Non-coding RNAs
5. Epigenetic methods
6. Genetic imprinting
7. Stem cell and differentiation-associated epigenetic events
8. Epigenetics of cancer
9. Epigenetics of autoimmune diseases
10. Epigenetic aspects of memory and neurological disorders
11. Epigenetic biomarkers and therapeutic interventions
12. X-chromosome inactivation