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Epigenetics - The Missing Link in Understanding Pathogeneses?

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

  • Tibor Attila RAUCH

    senior research fellow,
    Department of Medical Biology and Central Electron Microscope Laboratory

Number of hours/semester

lectures: 12 hours

practices: 0 hours

seminars: 0 hours

total of: 12 hours

Subject data

  • Code of subject: OSF-MLP-T
  • 1 kredit
  • Dentistry
  • Optional modul
  • autumn
Prerequisites:

-

Course headcount limitations

min. 5 – max. 15

Available as Campus course for 2 fő számára. Campus-karok: ÁOK ETK GYTK TTK

Topic

Why can one member of a family develop a tumor and not the other? Can the lifestyle of our parents and grandparents affect our health? What molecular factors and mechanisms may be responsible for the inheritance of acquired traits? Is epigenetics the missing link between genetics, environment and disease? The course will focus primarily on these questions and will present the most commonly used epigenetic techniques.

Lectures

  • 1. Milestones of epigenetics - from Conrad Waddington to David Allis - Dr. Rauch Tibor Attila
  • 2. DNA methylation and demethylation – the first discovered epigenetic alterations - Dr. Rauch Tibor Attila
  • 3. Histone protein-related epigenetic signals - Dr. Rauch Tibor Attila
  • 4. Non-coding RNAs (miRNA, piRNA and lncRNA) in cell biology and pathogeneses - Dr. Rauch Tibor Attila
  • 5. Epigenetic methods, including single-locus and genome-wide analysis tools - Dr. Rauch Tibor Attila
  • 6. Genetic imprinting and X chromosome inactivation - Dr. Rauch Tibor Attila
  • 7. Stem cell and differentiation-associated epigenetic events - Dr. Rauch Tibor Attila
  • 8. Epigenetics of cancer - Dr. Rauch Tibor Attila
  • 9. Epigenetics of autoimmune diseases - Dr. Rauch Tibor Attila
  • 10. Epigenetic aspects of memory and neurological disorders - Dr. Rauch Tibor Attila
  • 11. Epigenetic biomarkers and therapeutic interventions - Dr. Rauch Tibor Attila
  • 12. Exam (oral or written) - Dr. Rauch Tibor Attila

Practices

Seminars

Reading material

Obligatory literature

-

Literature developed by the Department

PowerPoint presentation according to lectures

Notes

-

Recommended literature

Handbook of Epigenetics, 2nd Edition, Editors: Trygve Tollefsbol, eBook ISBN: 9780128054772, Hardcover ISBN: 9780128053881, Academic Press, Published Date: 7th August 2017

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Closing test

Making up for missed classes

None

Exam topics/questions

1. Milestones of epigenetics
2. DNA methylation and demethylation
3. Histone protein-related epigenetic signals
4. Non-coding RNAs
5. Epigenetic methods
6. Genetic imprinting
7. Stem cell and differentiation-associated epigenetic events
8. Epigenetics of cancer
9. Epigenetics of autoimmune diseases
10. Epigenetic aspects of memory and neurological disorders
11. Epigenetic biomarkers and therapeutic interventions
12. X-chromosome inactivation

Examiners

Instructor / tutor of practices and seminars

Rólunk