Molecular Toxicology - lecture

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 28 hours

practices: 0 hours

seminars: 0 hours

total of: 28 hours

Subject data

  • Code of subject: OBH-010-E
  • 2 kredit
  • Biotechnology MSc
  • Specialty in Medical Biotechnology modul
  • autumn
Prerequisites:

-

Exam course:

yes

Course headcount limitations

min. 1 – max. 30

Topic

Molecular toxicology as a subject deals with the toxic (including teratogenic and carcinogenic) effects of drugs and xenobiotics caused by overdose or excessive exposure. It describes the general aspects of toxicology, the mechanisms of toxicity (including the major influencing factors), the harmful effects, and certain aspects of the treatment options. In addition, toxicity testing will be also discussed.

Lectures

  • 1. Introduction of toxicology. - Dr. Poór Miklós
  • 2. The principles of toxicodynamics. - Dr. Poór Miklós
  • 3. The principles of toxicokinetics I. - Dr. Poór Miklós
  • 4. The principles of toxicokinetics II. - Dr. Poór Miklós
  • 5. The principles of toxicokinetics III. - Dr. Poór Miklós
  • 6. The principles of toxicokinetics IV. - Dr. Poór Miklós
  • 7. Toxic effects caused by biological mimicri I. - Dr. Poór Miklós
  • 8. Toxic effects caused by biological mimicri II. - Dr. Poór Miklós
  • 9. Disruption of cellular energy production I. - Dr. Poór Miklós
  • 10. Disruption of cellular energy production II. - Dr. Poór Miklós
  • 11. Disruption of cell homeostasis and/or physiology I. - Dr. Poór Miklós
  • 12. Disruption of cell homeostasis and/or physiology II. - Dr. Poór Miklós
  • 13. Xenobiotics causing tissue injury or tissue necrosis - Dr. Poór Miklós
  • 14. Xenobiotics causing CNS toxicity - Dr. Poór Miklós
  • 15. Summary and consultation I. - Dr. Poór Miklós
  • 16. Summary and consultation II. - Dr. Poór Miklós
  • 17. Oxidative damage and adduct formation I. - Hartnerné Dr. Pohóczky Krisztina
  • 18. Oxidative damage and adduct formation II. - Hartnerné Dr. Pohóczky Krisztina
  • 19. Chemical carcinogenesis I. - Hartnerné Dr. Pohóczky Krisztina
  • 20. Chemical carcinogenesis II. - Hartnerné Dr. Pohóczky Krisztina
  • 21. Chemical teratogenesis I. - Hartnerné Dr. Pohóczky Krisztina
  • 22. Chemical teratogenesis II. - Hartnerné Dr. Pohóczky Krisztina
  • 23. Toxicity testing I. - Hartnerné Dr. Pohóczky Krisztina
  • 24. Toxicity testing II. - Hartnerné Dr. Pohóczky Krisztina
  • 25. Toxicity testing III. - Hartnerné Dr. Pohóczky Krisztina
  • 26. Toxicity testing IV. - Hartnerné Dr. Pohóczky Krisztina
  • 27. Summary and consultation III. - Hartnerné Dr. Pohóczky Krisztina
  • 28. Summary and consultation IV. - Hartnerné Dr. Pohóczky Krisztina

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Slides of each lecture will be available for the students on Neptun Meet Street.

Notes

Recommended literature

C.D. Klassen (ed.): Casarett & Doull's Toxicology. The Basic Science of Poisons. 9th edition, McGraww-Hill, 2019.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Students are required to take two mid-semester written tests, which are scheduled for weeks 7 and 14, approximately. These tests will contain multiple choice and short essay type questions. The average score of these two mid-semester tests (%) will be evaluated. We will offer a final grade for those reaching a mid-term result of at least 50%.

Making up for missed classes

Missed classes cannot be made up.

Exam topics/questions

The exam includes each topic discussed during the lectures and presented in lecture slides (available in Neptun Meet Street). Those have not achieved at least 50% in mid-term tests have to take a written exam during the exam period.

Examiners

  • Dr. Poór Miklós
  • Hartnerné Dr. Pohóczky Krisztina

Instructor / tutor of practices and seminars