Pharmacodynamics 3

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 24 hours

practices: 0 hours

seminars: 24 hours

total of: 48 hours

Subject data

  • Code of subject: OPG-GS3-T
  • 4 kredit
  • Pharmacy
  • Pharm. theoretical module and practical skills modul
  • autumn
Prerequisites:

OPG-GH2-T completed , OPO-MA2-T completed , OPG-GT4-T completed

Exam course:

yes

Course headcount limitations

min. 1 – max. 100

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs, antiviral antiprotozoal, anthelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases; immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age, diet and diseases on drug action; drug interactions.

Lectures

  • 1. Corticosteroids I - Dr. Pethő Gábor István
  • 2. Corticosteroids II - Dr. Pethő Gábor István
  • 3. Corticosteroids III - Dr. Pethő Gábor István
  • 4. Oestrogens and anti-oestrogens - Dr. Pethő Gábor István
  • 5. Progestins and anti-progestins - Dr. Pethő Gábor István
  • 6. Postmenopausal hormone therapy. Hormonal contraceptives - Dr. Pethő Gábor István
  • 7. Androgens, anabolic steroids and anti-androgens I - Dr. Pethő Gábor István
  • 8. Androgens, anabolic steroids and anti-androgens II - Dr. Pethő Gábor István
  • 9. Thyroid hormones, antithyroid drugs I - Dr. Börzsei Rita Judit
  • 10. Thyroid hormones, antithyroid drugs II - Dr. Börzsei Rita Judit
  • 11. Hypothalamic and pituitary hormones I - Dr. Poór Miklós
  • 12. Hypothalamic and pituitary hormones II - Dr. Poór Miklós
  • 13. Hypothalamic and pituitary hormones III - Dr. Poór Miklós
  • 14. Insulin, oral hypoglycaemic agents I - Dr. Sánticsné Dr. Pintér Erika
  • 15. Insulin, oral hypoglycaemic agents II - Dr. Sánticsné Dr. Pintér Erika
  • 16. Insulin, oral hypoglycaemic agents III Glucagon - Dr. Sánticsné Dr. Pintér Erika
  • 17. Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis I - Dr. Börzsei Rita Judit
  • 18. Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis II - Dr. Börzsei Rita Judit
  • 19. Drugs used in neoplastic diseases I - Dr. Pethő Gábor István
  • 20. Drugs used in neoplastic diseases II - Dr. Pethő Gábor István
  • 21. Drugs used in neoplastic diseases III - Dr. Pethő Gábor István
  • 22. Drugs used in neoplastic diseases IV - Dr. Pethő Gábor István
  • 23. Immunosuppressants and immunomodulators II - Dr. Sánticsné Dr. Pintér Erika
  • 24. Drugs used to treat rheumatoid arthritis - Dr. Sánticsné Dr. Pintér Erika

Practices

Seminars

  • 1. Basic principles of antimicrobial chemotherapy
  • 2. Sulphonamides and trimethoprim
  • 3. Fluoroquinolones, nitroimidazoles
  • 4. Antibiotics impairing the function of the bacterial cell envelope I
  • 5. Antibiotics impairing the function of the bacterial cell envelope II
  • 6. Antibiotics impairing the function of the bacterial cell envelope III
  • 7. Aminoglycosides
  • 8. Macrolide antibiotics
  • 9. Tetracyclines, chloramphenicol
  • 10. Linezolid, clindamycin, streptogramins
  • 11. Antituberculotic drugs
  • 12. Anti-leprosy drugs
  • 13. Antifungal drugs
  • 14. Antiseptics I
  • 15. Antiseptics II
  • 16. Antiviral drugs I
  • 17. Antiviral drugs II
  • 18. Antiviral drugs III
  • 19. Antiprotozoal drugs I
  • 20. Antiprotozoal drugs II
  • 21. Anthelminthic drugs I
  • 22. Anthelminthic drugs II
  • 23. Pharmacogenetics, pharmacogenomics
  • 24. Effects of age, diet and disease on drug action. Drug interactions

Reading material

Obligatory literature

Literature developed by the Department

Electronic handouts are provided for most topics.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019
B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

After the 10th week of the semester, a midterm test is written. The test covers the material of the seminars of the first 10 weeks of the semester. Students are required to reach at least 50%. Should someone fail to reach 50%, the semester performance will not be accepted and the student cannot take the exam. In such a case, students not reaching the required 50% on the first midterm test will have the possibility to repeat the written test until the end of the semester. In case of a final failure (that is after the improvement attempt), the student cannot take the exam.

Making up for missed classes

There is no way to make up for missed lectures or seminars.

Exam topics/questions

Reqirements: The semester is closed with the final exam. The exams are oral. The required topics are dealt with during the three courses of pharmacodynamics, including both lectures and seminars.

Exam questions:
1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated by physicochemical interactions)
2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy
3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs
4. Mechanisms of drug antagonisms
5. Transport of drugs across membranes
6. Absorption of drugs
7. Distribution of drugs
8. Biotransformation of drugs
9. Excretion of drugs
10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses
11. Harmful effects of drugs and their mechanisms
12. Factors influencing drug effects: genetic constitution, age, diet, disease
13. Drug interactions
14. Cholinergic agonists and cholinesterase inhibitors
15. Muscarinic receptor antagonists
16. Neuromuscular blocking agents. Drugs acting on autonomic ganglia
17. Agents acting on the biosynthesis, storage, release and elimination of catecholamines
18. Adrenergic receptor agonists
19. Adrenergic receptor antagonists
20. Local anaesthetics
21. Calcium channel blockers
22. Drugs acting on the renin-angiotensin-aldosterone system
23. Diuretic drugs
24. Positive inotropic and other drugs used for treating congestive heart failure
25. Antianginal drugs. Drugs that increase regional blood flow
26. Antihypertensive drugs
27. Antiarrhythmic drugs
28. Antianxiety and hypnotic drugs
29. Alcohols: pharmacology, toxicology
30. Antipsychotic drugs
31. Antidepressants
32. Central nervous system stimulants. Nootropic drugs
33. Drug treatment of neurodegenerative disorders
34. General anaesthetics
35. Antiepileptic drugs
36. Opioid analgesic drugs: morphine and codeine
37. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists
38. Non-steroidal antiinflammatory drugs: aspirin, paracetamol
39. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol
40. Adjuvant analgesics. Drugs used for treating gout. Centrally-acting muscle relaxants
41. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants
42. Drugs used for treating hyperlipoproteinaemias
43. Anticoagulants, antiplatelet drugs
44. Fibrinolytics, antifibrinolytics, hemostatic agents
45. Drugs affecting haematopoiesis
46. Histamine, H1 and H2 receptor antagonists
47. Serotonin, serotonin receptor agonists and antagonists. Drug treatment of migraine
48. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle
49. Drugs used in bronchial asthma
50. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents
51. Drugs used in the treatment of peptic ulcer
52. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis
53. Laxatives, antidiarrheal agents, drug treatment of inflammatory bowel diseases
54. Corticosteroids
55. Oestrogens, antioestrogens, progestins, antiprogestins
56. Postmenopausal hormone therapy and hormonal contraceptives
57. Androgens, anabolic steroids, antiandrogens
58. Thyroid hormones, antithyroid drugs
59. Hypothalamic and pituitary hormones
60. Insulin and oral hypoglycemic agents. Glucagon
61. Parathyroid hormone, calcitonin and vitamin D, drugs used for treating osteoporosis
62. Sulphonamides and trimethoprim. Fluoroquinolones. Nitroimidazoles
63. Beta-lactam antibiotics
64. Glycopeptide antibiotics, lipopeptides, polymyxines, gramicidins
65. Aminoglycosides. Macrolide antibiotics
66. Tetracyclines, chloramphenicol, linezolid, clindamycin, streptogramins
67. Antituberculotic drugs. Anti-leprosy drugs
68. Antifungal drugs
69. Drugs against herpes and hepatitis viruses
70. Drugs against HIV and influenza viruses
71. Antiprotozoal drugs
72. Anthelminthic drugs
73. Antiseptics and disinfectants
74. Antineoplastic drugs: alkylating agents, antimetabolites, alkaloids, antibiotics, hormonal agents
75. Antineoplastic drugs: biological therapy
76. Immunosuppressants and immunomodulators. Drug used to treat rheumatoid arthritis

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the student.

Examiners

  • Dr. Barthó Loránd
  • Dr. Pethő Gábor István

Instructor / tutor of practices and seminars

  • Dr. Börzsei Rita Judit
  • Dr. Fliszár-Nyúl Eszter
  • Dr. Kriszta Gábor
  • Dr. Pethő Gábor István
  • Dr. Poór Miklós