Pharmacodynamics 1 - Theory

Data

Official data in SubjectManager for the following academic year: 2022-2023

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system.

Lectures

• 1. Introduction to neuropharmacology. General characterization of the autonomic nervous system - Dr. Barthó Loránd
• 2. Cholinergic agonists - Dr. Barthó Loránd
• 3. Cholinesterase inhibitors I - Dr. Barthó Loránd
• 4. Cholinesterase inhibitors II - Dr. Barthó Loránd
• 5. Muscarinic receptor antagonists I - Dr. Barthó Loránd
• 6. Muscarinic receptor antagonists II - Dr. Barthó Loránd
• 7. Neuromuscular blocking agents I - Dr. Pethő Gábor István
• 8. Neuromuscular blocking agents II - Dr. Pethő Gábor István
• 9. Agents acting on biosynthesis, storage, release and elimination of catecholamines I - Dr. Pethő Gábor István
• 10. Agents acting on biosynthesis, storage, release and elimination of catecholamines II - Dr. Pethő Gábor István
• 11. Adrenergic receptor agonists I - Dr. Pethő Gábor István
• 12. Adrenergic receptor agonists II - Dr. Pethő Gábor István
• 13. Adrenergic receptor antagonists I - Dr. Pethő Gábor István
• 14. Adrenergic receptor antagonists II - Dr. Pethő Gábor István
• 15. Pharmacology of the calcium channels I - Dr. Pethő Gábor István
• 16. Pharmacology of the calcium channels II - Dr. Pethő Gábor István
• 17. Drugs acting on the renin-angiotensin-aldosterone system I - Dr. Poór Miklós
• 18. Drugs acting on the renin-angiotensin-aldosterone system II - Dr. Poór Miklós
• 19. Diuretic drugs I - Dr. Pethő Gábor István
• 20. Diuretic drugs II - Dr. Pethő Gábor István
• 21. Drugs used for treating congestive heart failure I - Dr. Kriszta Gábor
• 22. Drugs used for treating congestive heart failure II - Dr. Kriszta Gábor
• 23. Antiarrhythmic drugs I - Dr. Pethő Gábor István
• 24. Antiarrhythmic drugs II - Dr. Pethő Gábor István
• 25. Antianginal drugs I - Dr. Pethő Gábor István
• 26. Antianginal drugs II. Drugs increasing regional blood flow - Dr. Pethő Gábor István
• 27. Antihypertensive drugs I - Dr. Pethő Gábor István
• 28. Antihypertensive drugs II - Dr. Pethő Gábor István

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Electronic handouts are provided for most topics.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019
B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no midterm exam/test.

Making up for missed classes

There is no way to make up for missed classes.

Exam topics/questions

Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and practical classes. The criterion of admission to the exam is the successful completion of the Pharmacodynamics 1 practice course carried out in paralell (at least satisfactory midsemester grade).

Exam questions:
1. Basic mechanisms of drug actions
2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy
3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs
4. Mechanisms of drug antagonisms
5. Transport of drugs across membranes
6. Absorption of drugs, oral bioavailability and presystemic elimination
7. Distribution of drugs
8. Biotransformation of drugs
9. Excretion of drugs
10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses
11. Cholinergic agonists and cholinesterase inhibitors
12. Muscarinic receptor antagonists
13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia
14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines
15. Adrenergic receptor agonists
16. Adrenergic receptor antagonists
17. Local anaesthetics
18. Calcium channel blockers
19. Drugs acting on the renin-angiotensin-aldosterone system
20. Diuretic drugs
21. Positive inotropic and other drugs used to treat congestive heart failure
22. Antianginal drugs. Drugs that increase regional blood flow
23. Antihypertensive drugs
24. Antiarrhythmic drug

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the student.

Examiners

• Dr. Barthó Loránd
• Dr. Pethő Gábor István
• Dr. Poór Miklós

Instructor / tutor of practices and seminars