Human Physiology - lecture

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The goal of the course is to disclose human physiological processes to the students. By means of the knowledge of complex human physiological processes the biotechnology students will also learn the interconnections and mutual influences of physiological systems and they will utilize their knowledge in planning and executing related animal model experiments and pharmaceutical tests.

Lectures

• 1. Concept of homeostasis. Body fluid compartments and blood components. - Dr. Környei József László
• 2. Functions of cellular elements. Blood clotting. Blood groups. - Dr. Kertes Erika
• 3. Characteristics of the circulation in the human body. - Dr. Környei József László
• 4. Heart physiology: pacemaker activity, conductive system, electrical activity. - Dr. Környei József László
• 5. Control of circulation. - Dr. Környei József László
• 6. Respiration. Interaction between circulation and respiration. - Dr. Környei József László
• 7. Structure and function of the gastrointestinal tract: digestion and absorption. - Dr. László Kristóf
• 8. Hormonal regulation of the GI tract. - Dr. László Kristóf
• 9. Kidney circulation, glomerular filtration, clearance. - Dr. László Kristóf
• 10. Kidney: tubular transport mechanisms. Volume, osmotic and pH regulation. - Dr. László Kristóf
• 11. Energy balance, metabolic rate and heat regulation. - Dr. Környei József László
• 12. Mechanism of hormone action. Hypothalamo-hypophyseal control of hormonal secretion. - Dr. Lengyel Ferenc
• 13. Structure, function and hormonal control of reproductive organs. - Dr. Lengyel Ferenc
• 14. Hormonal regulation of carbohydrate and intermediary metabolism. - Dr. Lengyel Ferenc
• 15. Endocrinology of stress and adaptation. - Dr. Lengyel Ferenc
• 16. Endocrinology of thyroid gland. Regulation of calcium and phosphate homeostasis. - Dr. Környei József László
• 17. General properties of neurons and their functions. - Dr. Varga Csaba
• 18. Interaction and communication between neurons. Neuronal networks. - Dr. Varga Csaba
• 19. Proprioception, somatosensory mechanisms, pain and temperature sensation. - Dr. Buzás Péter
• 20. Physiology of muscles. Spinal cord reflexes and locomotion. - Dr. Barabás Klaudia
• 21. Coordination of body movements and balance. Extrapyramidal, cerebellar and cortical control of motion. Autonomic nervous system. - Péliné Dr. Kovács Anita
• 22. Structure of the eye, primary sensory processes in the retina and central visual information processing. - Dr. Buzás Péter
• 23. Hearing. - Dr. Buzásné Dr. Telkes Ildikó
• 24. Taste and smell. - Dr. Buzásné Dr. Telkes Ildikó
• 25. Electrical activity of the brain, Electroencephalography, evoked potentials. Sleep-wakefullness. - Dr. Lénárd László Csaba
• 26. Drive and motivation. Control of emotion and mood. - Dr. László Kristóf
• 27. Plasticity and regeneration in the nervous system. Learning and memory. - Dr. Gálosi Rita
• 28. Cerebral dominance. Speech and higher order cortical functions. - Dr. Gálosi Rita

Practices

Seminars

Reading material

Obligatory literature

Guyton & Hall: Textbook of Medical Physiology (Elsevier), 13th ed., 2015.

Literature developed by the Department

Find and read the relevant chapters in:
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 1, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 1, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 2, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 2, internet study material, printable notebook, 2019

Notes

Find and read the relevant chapters in:
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 1, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 1, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 2, internet study material, printable notebook, 2019
Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 2, internet study material, printable notebook, 2015

Recommended literature

Linda S. Costanzo: Physiology 5th ed., 2013;
Walter F. Boron, Emile L. Boulpaep: Medical Physiology 2nd ed. 2012

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Regular oral reports at the lab practices.

Making up for missed classes

The missed lab practice is advised to be covered by joining another group while the same topic is on schedule.

Exam topics/questions

1. Describe the body fluid compartments and explain the methods used for measurement of body fluid volumes
2. Describe the major plasma proteins and the other non-electrolytic constituents of blood and explain their function in the body
3. Describe the intra- and extracellular ionic components and explain their physiological functions
4. The structure, function and origin of erythrocytes
5. Characterize the various leukocytes indicating their origins and functions
6. Origin and function of blood platelets
7. The basic structure and metabolism of haemoglobin and the metabolism of iron
8. Describe the two pathways involved in the initiation of blood coagulation
9. Specific mechanism of clot formation
10. Describe the mechanism of fibrinolysis. Explain the significance of anticlotting mechanism
11. Regulation of H+ ion concentration in the blood
12. A-B-0 blood groups. The Rh blood types
13. The role of leukocytes in the defence mechanism
14. Mechanical activity of the heart and the three-component model of heart muscle. Calcium ion movements within the cardiac muscle cell
15. Generators and conductors of impulses in the heart. Refractory periods
16. The sequence of events in the cardiac cycle
17. The human electrocardiogram (ECG). Electrocardiography: bipolar and unipolar leads
18. The heart sounds. Phonocardiography (PCG)
19. Cardiac output: measurement, normal standards and physiological variations
20. Metabolism and energetics of cardiac muscle
21. Ventricular wall tension and the Laplace relationship
22. The heart-lung preparation (Starling's laws)
23. Arterial blood pressure: determinants of normal arterial blood pressure
24. The arterial and the venous pulse. Basic principles of hemodynamics.
25. Circulation through the capillaries
26. The properties, production and the movement of lymph
27. Circulation in the vein. Effect of gravity on circulation
28. The pulmonary circulation. Control of lung vessels
29. The coronary circulation
30. Cerebral circulation. The concept of blood-brain barrier
31. Splanchnic circulation
32. Skeletal muscle circulation. Cutaneous circulation
33. Nervous control of the heart
34. Control mechanisms of the circulatory system: general considerations
35. Local control of the vascular smooth muscle
36. Autoregulation of blood flow in tissues and organs
37. The function and importance of baroreceptors in the regulation of circulation
38. Reflex control mechanisms of circulation
39. Mechanisms of vasoconstriction and vasodilatation
40. Mechanics of respiration (functions of respiratory muscles, compliance, intrathoracic pressures, respiratory volumes)
41. Alveolar air, alveolar ventilation, dead spaces. Function of the respiratory passageways
42. Gaseous exchange in the lungs and tissues
43. O2 and CO2 transport in the body
44. Peripheral and central regulatory mechanisms of respiration. Respiratory reflexes
45. Chemical control of respiration. Acidosis, alkalosis
46. Different types of hypoxia. Oxygen treatment. Mechanisms of acclimatisation. Nitrogen narcosis. Decompression sickness
47. Describe the origin, composition, function and control of salivary secretion
48. Describe the origin, nature and function of gastric secretion indicating the mechanisms of regulation
49. Mechanism and regulation of gastrointestinal movements
50. Identify the pancreatic secretions, their components, their action and the substrates on which they act. Control mechanism of pancreatic secretion
51. Describe the basic ingredients and functions of the bile indicating the origin and fate of the components and the factors controlling bile secretions and gall bladder functions
52. Identify the components and functions of the intestinal system
53. Describe how carbohydrate is digested and absorbed indicating the enzymes involved
54. Describe how fat is digested and absorbed indicating the enzymes and secretions involved
55. Describe how protein is digested and absorbed indicating the enzymes and secretions involved
56. Dynamics of glomerular filtration. Glomerular filtration rate. Plasma clearance
57. Renal blood flow. Clearance of PAH. Extraction ratio. Filtration fraction
58. Regulation of renal blood flow and pressure. Renin-angiotensin system
59. Reabsorption and secretion of different substances in the renal tubule. Methods for their investigation
60. Concentrating and diluting mechanisms of the kidney
61. Fluid volume regulation of the body
62. Regulation of concentrations of ions in the extracellular fluid. Regulation of osmolality of body fluids
63. Basal metabolic rate. Describe factors influencing the basal metabolism
64. Define metabolic rate explaining those factors influencing the total expenditure of energy by the body
65. Describe the necessary elements of normal diet
66. The normal body temperature and its physiological variations. Hyperthermia, fever, hypothermia
67. Chemical regulation of body temperature, changes of regulation at low and high environmental temperature
68. Physical regulation of body temperature, changes of regulation at low and high environmental temperature
69. Central regulatory mechanisms of heat production and heat loss
70. Mechanisms of hormone action (receptors, intracellular mediators, cAMP, Ca2+ and diacylglycerol, protein kinases)
71. Mechanism of hormonal regulation. Negative and positive feedback controls in the endocrine system
72. The anterior pituitary hormones. Regulation of pituitary hormone secretions. Pituitary dysfunction
73. Function of growth hormone during development and after adolescence
74. Abnormalities of thyroid secretion. Goitrogens
75. Function of the thyroid gland. Iodine metabolism in the body
76. Hormonal changes during menstrual cycle
77. Hormonal changes during pregnancy. Role of placenta in pregnancy. Foeto-placental unit
78. Hormones of lactation
79. Mechanism of erection and ejaculation. The sexual act (coitus)
80. The function of testis, epididymis, seminal vesicle and prostate
81. Regulation of the sexual behaviour. Maternal behaviour
82. Physiological changes at puberty and climacteric
83. Vasopressin and oxytocin. Function of ANH (atrionatriuretic hormone)
84. The effects of prostaglandins
85. The endocrine pancreas
86. Function of insulin in the body. Diabetes mellitus
87. Hormonal control of carbohydrate metabolism
88. Hormonal control of calcium and phosphor homeostasis
89. Hormonal function of the adrenocortical system. Hypophyseal regulation of the adrenocortical system. Stress and the adaptation syndrome
90. Function and regulation of mineralocorticoids
91. Function and regulation of glucocorticoids
92. Consequences of hypo- and hyperfunction of the adrenal cortex. Androgens and oestrogens of the adrenal cortex.
93. Hormones of the adrenal medulla. Importance of the sympathoadrenal system
94. Physiology of ontogenesis and ageing.
95. Molecular mechanism of muscle contraction. The regulatory role of calcium ion
96. Mechanical characteristics of muscle. Differentiation of fast and slow twitch muscle fibres. Role of the connective tissue in the function of muscles
97. Mechanism of fatigue
98. Electromyography (EMG)
99. The source of energy for muscle contraction (aerobe and anaerobe processes). Heat production during contraction-relaxation cycle
100. The neuromuscular junction
101. Structural and functional differences between skeletal and smooth muscles. Mechanism of smooth muscle contraction
102. Membrane potential and action potential: explain their ionic mechanisms. Membrane properties of CNS neurons
103. The compound action potential. Conductive properties of various nerve fibres
104. Neurochemistry of synapses, neurotransmitters, postsynaptic receptors and neuromodulators. EPSP, IPSP
105. The myotatic (stretch) reflex. Gamma motoneurons
106. The motor units. Central control of muscle contractions
107. Types of mechanoreceptors and their role in motor control
108. How do cutaneous mechanoreceptors help to explore, learn and know our environment?
109. Somatosensory mechanisms of spinal cord and brain stem
110. Pain mechanisms, central and peripheral components
111. Descendent control (gating) of nociception and of pain reactions
112. Organisation of primary somatosensory cortex, thalamocortical projection and somatotopy
113. The human electroencephalogram (EEG). Evoked potential (EP) technique
114. Neural mechanisms of sleep and correlated somatic, autonomic and bioelectrical phenomena. The role of reticular formation in the sleep-wakefulness cycle
115. The diencephalon (hypothalamus), its motor, autonomic and hormonal regulatory function
116. Hunger and thirst. Central regulatory processes of food and water intake
117. Central mechanisms of locomotion
118. Decerebration rigidity and spinal shock (symptoms and mechanisms)
119. Postural and righting reflexes, their central mechanisms and localisation within the spinal cord, brain stem and neocortex
120. Structure and function of the extrapyramidal system
121. Symptoms after damages of different extrapyramidal structures. Role of neurotransmitters in the extrapyramidal functions
122. Importance of the cerebellum in coordination of movements
123. Cerebellar cortical mechanisms
124. Structure and function of the vestibular system
125. Functions of the autonomic nervous system. Autonomic reflexes
126. Humoral mediators in the autonomic nervous system. Adrenergic, cholinergic and opioid receptors
127. Structures, connections and functions of the limbic system
128. Functions of the motor cortex. Symptoms following its damage
129. Corticospinal (pyramidal) system. Consequences of lesions of the pyramidal pathways and the peripheral motoneuron
130. The concept of drive and motivation. Their integrated neural mechanisms. Reticular activating system
131. Emotions and their central nervous mechanisms
132. The phenomena of operant (instrumental) and classical (Pavlovian) conditioning. Mechanism of reinforcement
133. Electrical and chemical self-stimulation. Rewarding (positive) and punishing (negative) reinforcement. Simple learning processes. Exceptional forms of conditioning
134. Types and disorders of memory functions
135. Cerebral dominance. Lateralisation of functions in the hemispheres. Split-brain examinations
136. Functions of the parietal and temporal association (intrinsic) areas of the neocortex. Symptoms after damages (apraxia, agnosia)
137. Neurophysiological mechanisms of speech. Speech disorders
138. Functions of the frontal lobe (prefrontal intrinsic area)
139. Functions of the temporal lobe (Kluver-Bucy syndrome)
140. Central monoaminergic systems and their functional significance
141. Peripheral auditory mechanisms (conductive apparatus and cochlea)
142. Central auditory pathways, acoustic cortex and related mechanisms
143. Physiological optics
144. The retina. Photoreceptors and neuronal functions in the retina
145. Central visual pathways, the visual cortex and their functions
146. Colour vision. Stereoscopic vision
147. Peripheral and central mechanisms of olfaction
148. Peripheral and central mechanisms of sensation of taste
149. Plasticity in the nervous system. Consequences of sensory deprivation in the visual cortex. Ageing. Transplantation

Study material for the exam is the sum total of information covered in the obligatory textbook, on the homepage of the Institute, as well as knowledge given at the lectures and lab practices.
Figures of the lectures given are available on the homepage of Institute of Physiology and on the Neptun Meet Street.
Important messages on new information will be announced at the lectures and will be sent to you by course mails.
Please always find the current updated information and study materials on the homepage of the Institute of Physiology (physiology.aok.pte.hu).

Examiners

• Dr. Gálosi Rita
• Dr. Karádi Zoltán
• Dr. Kertes Erika
• Dr. Környei József László
• Dr. László Kristóf
• Dr. Lengyel Ferenc

Instructor / tutor of practices and seminars