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POZSGAI, Gábor

POZSGAI, Gábor

Telefon: 31642

Supervisor of the following TDK topics

Supervisor: PINTÉR, Erika

Co-supervisor: Dr. POZSGAI, Gábor

The treatment of the chronic inflammatory diseases, like allergic dermatitis and inflammatory bowel diseases (IBD) means still a problem of modern medicine. In the progression of these diseases neurogenic factors play an important role. Neuropeptides released from the capsaicin-sensitive sensory neurons, as well as inflammatory and immune cells influence the inflammatory processes, but their complex roles have not been cleared in precise details. Some of these peptides exert proinflammatory (SP, NKA, CGRP), while others exert antiinflammatory effects (opioid peptides, somatostatin, cortistatin, PACAP). Beside the classical peptide mediators of neural origin, hemokinin-1 and endokinins, expressed mainly in inflammatory and immune cells, were discovered a few years ago. All these peptide mediators are released on response to endogenous or exogenous stimuli, through the activation of Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1), or independently of that. Antagonising the effect of the proinflammatory peptides, as well as the precise identification of the mechanisms of antiinflammatory mediators may enable the development of antiinflammatory drugs acting on new target structures. Therefore, our experiments aim to investigate the interactions between the neurogenic components and the immune system in animal models of dermatitis and IBD, with the help of functional, morphological, immunological, molecular biological, as well as in vivo imaging techniques.
Key words: neuro-immune interaction, neuropeptides, skin, dermatitis, bowel, IBD, proinflammatory, antiinflammatory

Supervisor: POZSGAI, Gábor

Co-supervisor: Dr. BÁTAI, István Zoárd

In this topic effects of hydrogen sulfide, sodium polysulfide and dimethyl trisulfide are investigated. Beside classical models of nociception and inflammation, animal modles of neuropathic pain, arthritis and pancreatitis are utilized. Mechanical and heat sensitivity, myeloperoxidase enzyme activity, oedema formation, rate of plasma extravasation as well as activation of corresponding parts of the CNS by immunohistochemistry are detected during the experiments. 
 

Supervisor: PINTÉR, Erika

Co-supervisor: Dr. POZSGAI, Gábor

Among other members of the TRP receptor family, capsaicin-sensitive sensory neurons express Transient Receptor Potential Ankyrin 1 (TRPA1) ion channels. TRPA1 can be activated by several exogenous and endogenous chemical stimuli, such as pungent agents (mustard oil, cinnamaldehyde, allicin) and toxic gases (acrolein, formaldehyde) resulting in the release of inflammatory peptides (SP, CGRP). Hydrogen-sulphide (H2S) is an important gaseous mediator of the human body. In the recent years, there have been several data published, indicating that H2S may be involved in various vascular and inflammatory processes. Moreover, it has also been suggested that H2S may act on capsaicin-sensitive peptidergic neurons. The aim of our investigation is to reveal the interaction of neural and non-neural TRPA1 receptors and H2S in microcirculatory processes, in dermal, intestinal and airway inflammations, as well as in neuropathic states, with the help of in vivo and in vitro experimental methods.