All colleagues of the unit

HELYES, Zsuzsanna

HELYES, Zsuzsanna

Ph.D., Dr. Habil., D. Sc., akadémia lev. tag

Telefon: 35591, 29043

Supervisor of the following TDK topics

Supervisor: HELYES, Zsuzsanna

Co-supervisor: Dr. HORVÁTH, Ádám István

TRPA1 and TRPV4 receptors are expressed on capsaicin-sensitive sensory neurons, immune cells and keratinocytes. TRPA1 receptors are activated by pungent agents (mustard oil, cinnamaldehyde), exogenous and endogenous toxic chemicals, as well as inflammatory mediators and noxious cold (<17°C). The activation and sensitization mechanisms and interactions of TRPV4 are less known. Therefore, we aim to analyze their roles and cross-talks in inflammatory and neuropathic pain models with thermo- and mechanonociceptive testing methods using gene-deleted mice pharmacological interventions.

Supervisor: HELYES, Zsuzsanna

Co-supervisor: Dr. HORVÁTH, Ádám István

Amino-oxidases neutralise the pharmacological effects of exogenous and endogenous biogen amines. However, their reaction products (aldehyde, hydrogen-peroxide, ammonia) are biologically active, potentially toxic compounds. Although the substrate-specificity of these enzymes and their sensitivity to enzyme inhibitors is well-known, their physiological and pathophysiological role is not cleared yet. Therefore, as a continuation of our former experiments, we investigate their function in neuropathic, postoperative and inflammatory pain conditions.

Supervisor: HELYES, Zsuzsanna

Co-supervisor: Dr. GASZNERNÉ, Dr. Kormos Viktória

Clinical and experimental data indicates that chronic stress increases pain sensitivity, but the underlying mechanisms are largely unknown. The pain perception of mice exposed to chronic restraint stress is assessed with functional tests in our experiments. Neuronal activation caused by stress and pain is examined with immunohistochemistry both in the central and peripheral nervous system. The role of peripheral capsaicin-sensitive sensory neurones is explored with desensitized animals. Investigation of the stress-induced hyperalgesia may contribute to the understanding of stress-related pain syndromes (e.g.: fibromyalgia) and to the identification of new drug targets.

Supervisor: HARTNERNÉ, Pohóczky Krisztina

Co-supervisor: Prof. Dr. HELYES, Zsuzsanna

Endometriosis is a complex estrogen-dependent an inflammatory condition defined as the presence of endometrium-like tissue at ectopic sites. The disease affects around 10-12 % of women of reproductive age, causing chronic pain and infertility. Complex sensory-vascular and immune reactions play a role in its development and progression, but the underlying mechanism and therapy remains to be clarified. Capsaicin-sensitive nerve ending-related cytokines and neuropeptides as well as Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are assumed to be involved in endometriosis and consequently chronic pain, but their role is yet unclear. During this thesis, we investigate inflammatory cytokines, chemokines, growth factors, neuropeptides, and nociceptive receptors in human serum and tissue samples as well as in human endometriosis and stromal cell lines.