Supervisor: HARTNERNÉ, Pohóczky Krisztina
Co-supervisor: Prof. Dr. HELYES, Zsuzsanna
Endometriosis is a complex estrogen-dependent an inflammatory condition defined as the presence of endometrium-like tissue at ectopic sites. The disease affects around 10-12 % of women of reproductive age, causing chronic pain and infertility. Complex sensory-vascular and immune reactions play a role in its development and progression, but the underlying mechanism and therapy remains to be clarified. Capsaicin-sensitive nerve ending-related cytokines and neuropeptides as well as Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are assumed to be involved in endometriosis and consequently chronic pain, but their role is yet unclear. During this thesis, we investigate inflammatory cytokines, chemokines, growth factors, neuropeptides, and nociceptive receptors in human serum and tissue samples as well as in human endometriosis and stromal cell lines.