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ACZÉL, Timea

ACZÉL, Timea

Telefon: 35386

Supervisor of the following TDK topics

Supervisor: BÖLCSKEI, Kata

Co-supervisor: ACZÉL, Timea

Orofacial pain and primary headache disorders are among the most debilitating pain conditions. Due to several therapy-resistant patients, the therapy of migraine is far from being optimal, and it is still an unmet medical need. Therefore, understanding the pathophysiological mechanisms is crucial to identify key mediators and determine novel therapeutical targets. Thus, we investigate the role of different potential target molecules in pain models using pharmacological tools (agonists, antagonists) and gene-deficient mice. Tissue samples from our experiments are analyzed by qPCR for gene expression and immunohistochemistry for protein level analysis.

Supervisor: BÖLCSKEI, Kata

Co-supervisor: ACZÉL, Timea

Orofacial pain and primary headache disorders are among the most debilitating pain conditions. Due to several therapy-resistant patients, the therapy of migraine is far from being optimal, and it is still an unmet medical need. Therefore, understanding the pathophysiological mechanisms is crucial to identify key mediators and determine novel therapeutical targets. Thus, we investigate the role of different potential target molecules in pain models using pharmacological tools (agonists, antagonists) and gene-deficient mice. In our experiments, we investigate different reactions with vascular imaging and behavioural studies, using chemical or electrical activation of the trigeminovascular system.