Supervisor: HELYES, Zsuzsanna
Co-supervisor: Dr. GASZNERNÉ, Kormos Viktória
Clinical and experimental data indicates that chronic stress increases pain sensitivity, but the underlying mechanisms are largely unknown. The pain perception of mice exposed to chronic restraint stress is assessed with functional tests in our experiments. Neuronal activation caused by stress and pain is examined with immunohistochemistry both in the central and peripheral nervous system. The role of peripheral capsaicin-sensitive sensory neurones is explored with desensitized animals. Investigation of the stress-induced hyperalgesia may contribute to the understanding of stress-related pain syndromes (e.g.: fibromyalgia) and to the identification of new drug targets.