Data
Official data in SubjectManager for the following academic year: 2021-2022
Course director
-
Dr. Csaba HETÉNYI
associate professor,
Department of Pharmacology and Pharmacotherapy -
Number of hours/semester
lectures: 12 hours
practices: 0 hours
seminars: 0 hours
total of: 12 hours
Subject data
- Code of subject: OPF-DR2-T
- 1 kredit
- Pharmacy
- Optional modul
- spring
-
Course headcount limitations
min. 1 – max. 25
Available as Campus course for 5 fő számára. Campus-karok: ÁOK ETK GYTK TTK
Topic
The course is a continuation of its parent course Drug Design. Additional details of selected topics of the parent course and also new topics are provided. In Journal Club sessions, recent research articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design. The lectures will take place weekly or (if possible) contracted into 4 blocks.
Lectures
- 1. Rational design: main concepts, phases, and techniques - Dr. Hetényi Csaba
- 2. Target-based optimization. Case study: ACE inhibitors - Dr. Hetényi Csaba
- 3. Ligand libraries, combinatorial synthesis, screening, modifications, and the pharmacophore. Case study: Artemisinin - Dr. Hetényi Csaba
- 4. Antiviral design - Dr. Hetényi Csaba
- 5. Antibacterial design - Dr. Zsidó Balázs Zoltán
- 6. Targeting ion channels - Dr. Zsidó Balázs Zoltán
- 7. Targeting receptors 1. - Dr. Zsidó Balázs Zoltán
- 8. Targeting receptors 2. - Dr. Zsidó Balázs Zoltán
- 9. Targeting the signaling pathways - Dr. Zsidó Balázs Zoltán
- 10. Journal club 1. Mechanisms and ligand optimizations - Dr. Hetényi Csaba
- 11. Journal club 2. Anti-cancer agents and ion channels - Dr. Hetényi Csaba
- 12. Test - Dr. Hetényi Csaba
Practices
Seminars
Reading material
Obligatory literature
Literature developed by the Department
The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.
Notes
Recommended literature
Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
There is a final test announced at the end of the semester. The test will include multiple choice questions or short essays. A mark is offered according to the results of the written test or optionally by evaluation of the student's presentation prepared for the Journal Club. The student can improve the mark according to university regulations.
Making up for missed classes
Replacement is possible according to personal consultation.
Exam topics/questions
Lists of questions will be provided at the end of each lecture specifying the required knowledge.