Pharmacology 1

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

Number of hours/semester

lectures: 42 hours

practices: 0 hours

seminars: 28 hours

total of: 70 hours

Subject data

  • Code of subject: OAK-PH1-T
  • 5 kredit
  • General Medicine
  • Clinical modul
  • autumn
Prerequisites:

OAP-KO2-T completed , OAP-PA2-T completed

Exam course:

yes

Course headcount limitations

min. 5

Topic

The general aim of the subject is to provide the medical students with all the basic information in pharmacology necessary to understand the actions of drugs and the clinical pharmacotherapy and to pass the Foreign Medical Graduate Examination in Medical Sciences. Pharmacology can be defined as the study of the manner in which the function of living systems is affected by chemical agents. Therefore, the students should be familiar with the basic knowledge of the physiological, pathophysiological and biochemical background of the pharmacological and therapeutic approaches. On the other hand, drug therapy is closely related to the clinical aspects of diseases.
The following topics will be dealt with. Definitions, prescription writing, drug development, drug formulations. General aspects of mechanisms of drug actions: characterization of drug-receptor interactions, mechanisms of drug antagonism, signal transduction mechanisms of drug receptors. General and quantitative aspects of pharmacokinetics: absorption, distribution and elimination of drugs. Pharmacology of the autonomic nervous system. Cardiovascular pharmacology: drugs used to treat congestive heart failure, antianginal, antiarrhythmic, antihypertensive drugs, diuretics, calcium channel blockers, drugs acting on the renin-angiotensin-aldosterone system. Non-steroidal antiinflammatory drugs. Drugs used to treat cancer, immunopharmacology.

Lectures

  • 1. Introduction to pharmacology - Dr. Sánticsné Dr. Pintér Erika
  • 2. Introduction to neuropharmacology - Dr. Sánticsné Dr. Pintér Erika
  • 3. Cholinergic agonists and cholinesterase inhibitors - Dr. Sánticsné Dr. Pintér Erika
  • 4. Muscarinic receptor antagonists - Dr. Sánticsné Dr. Pintér Erika
  • 5. Neuromuscular blocking agents - Dr. Pethő Gábor István
  • 6. Agents acting on the biosynthesis, storage, release and elimination of catecholamines - Dr. Pethő Gábor István
  • 7. Adrenergic receptor agonists I - Dr. Sánticsné Dr. Pintér Erika
  • 8. Adrenergic receptor agonists II - Dr. Sánticsné Dr. Pintér Erika
  • 9. Adrenergic receptor antagonists - Dr. Sánticsné Dr. Pintér Erika
  • 10. Pharmacological aspects of the purinergic system and nitric oxide - Dr. Sánticsné Dr. Pintér Erika
  • 11. Pharmacological significance of the protein and peptide mediators - Dr. Szőke Éva
  • 12. Calcium channel blockers - Dr. Tamasikné Dr. Helyes Zsuzsanna
  • 13. Drugs acting on the renin-angiotensin-aldosterone system - Dr. Sánticsné Dr. Pintér Erika
  • 14. Diuretic drugs I - Dr. Gregus Zoltán
  • 15. Diuretic drugs II - Dr. Gregus Zoltán
  • 16. Antiarrhythmic drugs I - Dr. Pethő Gábor István
  • 17. Antiarrhythmic drugs II - Dr. Pethő Gábor István
  • 18. Drugs used to treat congestive heart failure - Dr. Tamasikné Dr. Helyes Zsuzsanna
  • 19. Antianginal drugs - Dr. Pethő Gábor István
  • 20. Antihypertensive drugs - Dr. Sánticsné Dr. Pintér Erika
  • 21. Principles of fluid therapy - Dr. Sándor Zoltán
  • 22. Drugs used to treat hyperlipoproteinemias I - Dr. Borbély Éva
  • 23. Drugs used to treat hyperlipoproteinemias II - Dr. Borbély Éva
  • 24. Drugs affecting hemostasis I - Dr. Sánticsné Dr. Pintér Erika
  • 25. Drugs affecting hemostasis II - Dr. Sánticsné Dr. Pintér Erika
  • 26. Drugs affecting hemostasis III - Dr. Sánticsné Dr. Pintér Erika
  • 27. Drugs affecting hematopoiesis I - Dr. Tamasikné Dr. Helyes Zsuzsanna
  • 28. Drugs affecting hematopoiesis II - Dr. Tamasikné Dr. Helyes Zsuzsanna
  • 29. Pharmacological targets of inflammation - Dr. Börzsei Rita Judit
  • 30. Histamine and histamine receptor antagonists - Dr. Sándor Zoltán
  • 31. Serotonin, serotonin receptor agonists and antagonists - Dr. Pethő Gábor István
  • 32. Pharmacology of eicosanoids - Dr. Pethő Gábor István
  • 33. Non-steroidal antiinflammatory drugs I - Dr. Pethő Gábor István
  • 34. Non-steroidal antiinflammatory drugs II - Dr. Pethő Gábor István
  • 35. Basics of biological therapy - Dr. Sánticsné Dr. Pintér Erika
  • 36. Immunosuppressants - Dr. Sánticsné Dr. Pintér Erika
  • 37. Immunomodulators. Drug treatment of rheumatoid arthritis - Dr. Sánticsné Dr. Pintér Erika
  • 38. Drugs used in the chemotherapy of neoplastic diseases I - Dr. Sándor Zoltán
  • 39. Drugs used in the chemotherapy of neoplastic diseases II - Dr. Sándor Zoltán
  • 40. Drug research - Dr. Hetényi Csaba
  • 41. Drug development - Dr. Sánticsné Dr. Pintér Erika
  • 42. Future perscpectives of pharmacology - Dr. Sánticsné Dr. Pintér Erika

Practices

Seminars

  • 1. Basic terms of pharmacology
  • 2. Drug names, drug compendia
  • 3. Basic mechanisms of drug actions
  • 4. Characterization of agonist-receptor interaction I
  • 5. Characterization of agonist-receptor interaction II
  • 6. Characterization of agonist-receptor interaction III
  • 7. Signal transduction
  • 8. Tachyphylaxis and tolerance
  • 9. Mechanisms of antagonism
  • 10. Inverse agonism
  • 11. Basic concepts of pharmacokinetics 1. Approaches and the therapeutic role of pharmacokinetics. Physiologic background of pharmacokinetic events after intra- and extravascular administration
  • 12. Basic concepts of pharmacokinetics 2. Dose, systemic concentration, exposure, and response (effect). Connection of pharmacokinetics and pharmacodynamics
  • 13. Events following an intravascular bolus. Elimination 1: General concerns and the timing of elimination. The clearance. The competition of elimination and distribution
  • 14. The role of transport and membranes in pharmacokinetics
  • 15. Distribution. Elimination 2: Hepatic and renal elimination. Excretion. Metabolism
  • 16. Physiologic and physicochemical determinants of drug absorption
  • 17. Events following an extravascular dose. Absorption
  • 18. Therapeutic regimens
  • 19. Individualization of the drug therapy
  • 20. Drug formulations I
  • 21. Drug formulations II
  • 22. Prescription writing. Drugs increasing regional blood flow
  • 23. Drug treatment of obesity
  • 24. Drug treatment of gout
  • 25. Drugs acting on smooth muscle
  • 26. Drugs acting on the respiratory tract I
  • 27. Drugs acting on the respiratory tract II
  • 28. Drugs acting on the respiratory tract III

Reading material

Obligatory literature

Literature developed by the Department

Materials related to the topics discussed in lectures and seminars will be available in Neptun.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2020
B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books, McGraw-Hill, 2018

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no mid-semester test.

Making up for missed classes

Each missed seminar has to be made up for with another group in the same week.

Exam topics/questions

1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels,
enzymes, carrier systems and effects mediated by physicochemical interactions)
2. Characterisation of agonist-receptor interaction: occupancy, affinity, concentration-
response curve, potency, efficacy, quantal dose-response curve
3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and
tolerance to drugs
4. Mechanisms of drug antagonisms. Inverse agonism
5. The role of transport and membranes in pharmacokinetics
6. Absorption of drugs
7. Distribution of drugs
8. Metabolism of drugs
9. Excretion of drugs
10. Basic concepts of pharmacokinetics. Therapeutic regimens. Individualization of drug therapy.
11. Drug formulations. Prescription writing
12. Drug research and development
13. Cholinergic agonists and cholinesterase inhibitors
14. Muscarinic receptor antagonists
15. Neuromuscular blocking agents
16. Agents acting on the biosynthesis, storage, release and elimination of catecholamines
17. Adrenergic receptor agonists
18. Adrenergic receptor antagonists
19. Pharmacology of protein and peptide mediators, the purinergic system and nitric oxide
20. Calcium channel blockers
21. Drugs acting on the renin-angiotensin-aldosterone system
22. Diuretic drugs
23. Antiarrhythmic drugs
24. Drugs used to treat congestive heart failure
25. Antianginal drugs
26. Antihypertensive drugs
27. Drugs that increase regional blood flow. Drug treatment of obesity
28. Basic principles of fluid therapy
29. Drugs used to treat hyperlipoproteinemias
30. Anticoagulants, antiplatelet drugs
31. Fibrinolytics, antifibrinolytics, hemostatic agents
32. Drugs affecting hematopoiesis
33. Histamine, antihistaminic drugs
34. Serotonin, serotonin receptor agonists and antagonists. Drug treatment of migraine
35. Pharmacology of eicosanoids. Drugs acting on smooth muscle
36. Non-steroidal antiinflammatory drugs: aspirin, paracetamol
37. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol. Drugs
used to treat gout
38. Antineoplastic drugs: cytotoxic drugs
39. Antineoplastic drugs: biological therapy
40. Immunosuppressants, immunomodulators, treatment of rheumatoid arthritis
41. Drugs used to treat bronchial asthma
42. Drug treatment of allergic rhinitis. Antitussives, expectorants and mucolytics

Upon the oral exam, 2 exam topics are chosen. In addition to these exam topics, important parts of the exam are the questions that aim at assessing the general knowledge of the student. Bad performance in this part of the exam may lead to failure regardless of the answers to exam topics.

Examiners

  • Dr. Barthó Loránd
  • Dr. Borbély Éva
  • Dr. Börzsei Rita Judit
  • Dr. Horváth Ádám István
  • Dr. Pethő Gábor István
  • Dr. Pozsgai Gábor
  • Dr. Sánticsné Dr. Pintér Erika
  • Dr. Tamasikné Dr. Helyes Zsuzsanna

Instructor / tutor of practices and seminars

  • Dr. Borbély Éva
  • Dr. Börzsei Rita Judit
  • Dr. Csekő Kata
  • Dr. Gasznerné Dr. Kormos Viktória
  • Dr. Hetényi Csaba
  • Dr. Horváth Ádám
  • Dr. Horváth Ádám István
  • Dr. Konkoly János
  • Dr. Pethő Gábor István
  • Dr. Pozsgai Gábor
  • Dr. Sánticsné Dr. Pintér Erika
  • Dr. Simonné Dr. Hajna Zsófia Réka
  • Dr. Tamasikné Dr. Helyes Zsuzsanna
  • Dr. Zsidó Balázs Zoltán