Modern Drug Developmental Techniques - from the Molecules to the Human Clinical Studies

Data

Official data in SubjectManager for the following academic year: 2022-2023

Course director

  • Dr. Szőke Éva

    associate professor,
    Department of Pharmacology and Pharmacotherapy

Number of hours/semester

lectures: 12 hours

practices: 0 hours

seminars: 0 hours

total of: 12 hours

Subject data

  • Code of subject: OTF-MKV-T
  • 1 kredit
  • Biotechnology BSc
  • Optional modul
  • both semesters
Prerequisites:

-

Course headcount limitations

min. 1 – max. 50

Available as Campus course for 50 fő számára. Campus-karok: ÁOK ETK GYTK TTK

Topic

We will talk about what is the reason of drug development, about the history of drug development. We will compare the traditional drug discovery and modern drug development. Students will learn about target identification and validation, drug design and synthesis, selection and testing of lead molecules. They will learn about in vitro, ex vivo and in vivo preclinical drug development and in vivo animal models od pain, behavioral studies, depression and anxiety. They will learn about clinical phase trials.

Lectures

  • 1. Basic concepts of pharmacology. What is the reason of drug development? - Dr. Szőke Éva
  • 2. History of drug development. - Dr. Szőke Éva
  • 3. Traditional drug discovery and modern drug development. - Dr. Szőke Éva
  • 4. How we identify our drug target? - Dr. Szőke Éva
  • 5. Design and synthesis of drug molecules. - Dr. Szőke Éva
  • 6. Selection and testing of lead molecules. - Dr. Szőke Éva
  • 7. Testing of drug candidates, in vitro preclinical development. - Dr. Szőke Éva
  • 8. Testing of drug candidates, ex vivo preclinical development. - Dr. Szőke Éva
  • 9. In vivo animal experiments in drug development: pain models. - Dr. Szőke Éva
  • 10. In vivo animal experiments in drug development: behavioral studies, depression, anxiety studies. - Dr. Szőke Éva
  • 11. Clinical phase trials. - Dr. Szőke Éva
  • 12. Discussion of papers. - Dr. Szőke Éva

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Materials is pdf format.

Notes

Recommended literature

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

A small paper about the topic of the course.

Making up for missed classes

In agreement with the lecturer.

Exam topics/questions

1. Basic concepts of pharmacology. What is the reason of drug development?
2. History of drug development.
3. Traditional drug discovery and modern drug development.
4. How we identify our drug target?
5. Design and synthesis of drug molecules.
6. Selection and testing of lead molecules.
7. Testing of drug candidates, in vitro preclinical development.
8. Testing of drug candidates, ex vivo preclinical development.
9. In vivo animal experiments in drug development: pain models.
10. In vivo animal experiments in drug development: behavioral studies, depression, anxiety studies.
11. Clinical phase trials.

Examiners

Instructor / tutor of practices and seminars