All colleagues of the unit

REGLŐDI, Dóra

REGLŐDI, Dóra

M.D., Ph.D., DSc. Dr. Habil.

full professor , chair

Department of Anatomy

Telefon: 36392, 31232

Excellent practice instructor
2019, 2018, 2008, 2006, 2005, 2004, 2003, 2002, 2001, 1999

Supervisor of the following TDK topics

Supervisor: REGLŐDI, Dóra

Co-supervisor: Dr. FÜLÖP, Balázs Dániel

The aim of this topic is to study the relations between anatomy and its borderline sciences, with a specific attention to high-tech. As further goals we would like to discover new, innovative ideas in education and in science.

Supervisor: REGLŐDI, Dóra

Co-supervisor: Dr. RIVNYÁK, Ádám

PACAP (pituitary adenylate cyclase activating polypeptide) is a neuropeptide that plays a complex protective role in neurodegenerative diseases. The neuroprotective effects of PACAP have been described in Parkinson's disease, Huntington's disease and Alzheimer's disease models in vitro and in vivo models. Our aim is to show the differences in protein expression of brain areas from PACAP knockout and wild type mice, underlying these effects. In the experiment we use a mass spectrometric imaging technique, the MALDI Imaging, which can do direct proteomic analysis from histological slides surface. To verifying the results of IMS (Imaging Mass Spectrometry) we use LC-MS and immunfluorescent staining.

 

Supervisor: FARKAS, József

Co-supervisor: Prof. Dr. REGLŐDI, Dóra

Toxic effects during pregnancy  may have serious consequences on the development of the organism. One of these effects may be substance abuse of the pregnant woman. In the present research project we would like to make a detailed evaluation of the effects of THC and other drugs  on early life development.

Supervisor: REGLŐDI, Dóra

Co-supervisor: Dr. CSUTAK, Adrienn

The aim of our experiments is to study the effect of retinoprotective agents in different animal models (rat, mice) of retinal injuries (ischemia-reperfusion, chronic ischemia).  . Electrophysiological measurements (electroretinography, visual evoked potentials) are performed to detect the effect of different protective agents, we also complete our exmperiments with histological and biochemical examinations.  The student researchers have opportunity to learn the operation and the anesthesia of the animals,  to carry out electrophysiological measurements, and take part in the data analysis and assessment.
 

Supervisor: REGLŐDI, Dóra

Co-supervisor: Dr. JÜNGLING, Adél

PACAP (pituitary adenylate-cyclase activating polypeptide) is a multifunctional neuropeptide, highly abundant in the central and peripheral nervous system. Numerous experiments have shown that PACAP has neurotrophic and neuroprotective effects both in in vivo and in vitro studies of neurodegenerative diseases, like Parkinson’s and Althezimer’s diseases. The aim of our current experiment is to compare the tissues and organs of wild type and knockout mice of different ages, especially focusing on older groups of animals (such as 18-months-old animals). For this several histologycal staining techniques, immunohistochemical and molecular biological methods are used. Additionally behavioral tests are also performed on these animals.

Supervisor: TAMÁS, Andrea

Co-supervisor: Prof. Dr. REGLŐDI, Dóra

Few years ago we started our experiments to measure the PACAP level in human biological samples from healthy volunteers with radioimmunoassay examination. The aim of our study is  to examine the relation between PACAP level of different human tissue samples and different disorders (tumors, heart disorders, neurological and metabolic diseases).  We work in collaboration with many Clinics of the University on this project, therefore, the students can participate in basic research and also in clinical practice. 

Supervisor: REGLŐDI, Dóra

Co-supervisor: VÁCZY, Alexandra

Our research deals with the retinoprotective effects of different neuropeptides. We investigate the ischemic retinopathy in rats after bilateral common carotid occlusion (BCCAO). After the operation we apply intravitreal neuropeptide (PACAP fragments, glucagons, secretin) injections to check their retinoprotective effects. Intravitreal injection of these peptides are not possible in clinical practice therefore the application of PACAP eye-drop is also included in our research.
Other field of our project is a commonly occuring acute problem in ophthalmology, the retinal detachment. To model this condition we inject hyaluronic acid intravitreally afterwards we treat the eyes with either PACAP injection or eye-drop. After the treatments histological processes are used to define the morphological changes.

Supervisor: REGLŐDI, Dóra

Co-supervisor: Dr. CSUTAK, Adrienn

Functional measurements are performed to measure the mechanoniciceptive treshold of the rats using dinamic plantar aesthesiometry and Randall-Selitto test, and to determine the severity of cold allodynia. Examination of the histological alterations of peripheral nerves and the spinal cord caused by diabetes using immunohistochemistry. Electronmicroscopy and molecular biological examinations are also performed.