Supervisor: GASZNER, Balázs
Co-supervisor: Dr. GASZNER, Tamás
Co-inciding genetic background, epigenetic effects and acquired chronic stress factors precipitate the symptoms of depression. The PACAP deficient mouse exerts depression like phenotype. Exposing them to maternal deprivation causing epigenetic changing, followed by chronic stress exposure in adulthood may provoke the occurrence of depression. To validate our model we perform behavioral tests, hormone measurements, determine the changes in brain neurotransmitter- and neuromodulator systems, and measure neuronal activation as well.